Abstract
Female aging is one of the most important factors that impacts human reproduction. With aging, there is a natural decline in female fertility. The decrease in fertility is slow and steady in women aged 30–35 years; however, this decline is accelerated after the age of 35 due to decreases in the ovarian reserve and oocyte quality. Human oocyte aging is affected by different environmental factors, such as dietary habits and lifestyle. The ovarian microenvironment contributes to oocyte aging and longevity. The immediate oocyte microenvironment consists of the surrounding cells. Crosstalk between the oocyte and microenvironment is mediated by direct contact with surrounding cells, the extracellular matrix, and signalling molecules, including hormones, growth factors, and metabolic products. In this review, we highlight the different microenvironmental factors that accelerate human oocyte aging and decrease oocyte function. The ovarian microenvironment and the stress that is induced by environmental pollutants and a poor diet, along with other factors, impact oocyte quality and function and contribute to accelerated oocyte aging and diseases of infertility.
Graphical Abstract
Keywords
- Aging and longevity
- Human
- Microenvironment
- Oocytes
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- AGEs:
-
Advanced glycation end products
- AKT:
-
Protein kinase B
- BCL2:
-
B-cell lymphoma-2
- CaMKII:
-
Calmodulin-dependent protein kinase II
- CAT:
-
Catalase
- CCs:
-
Cumulus cells
- cGMP:
-
Cyclic guanosine monophosphate
- COC:
-
Cumulus-oocyte complex
- COIII:
-
Cytochrome oxidase subunit 3
- CoQ10:
-
Coenzyme Q10
- Cx-43:
-
Connexin 43
- EGF:
-
Epidermal growth factor
- EGFR:
-
EGF receptor
- FADD:
-
Fas-Associated protein with a Death Domain
- FAS:
-
Free α-subunit
- FasL:
-
Fas/Fas ligand
- FoxO:
-
Forkhead box O
- FSH:
-
Follicle-stimulating hormone
- GCs:
-
Granulosa cells
- GnRH:
-
Gonadotropin-releasing hormone
- GSSPx:
-
Glutathione peroxidase
- GST:
-
Glutathione S transferase
- GTP:
-
Guanosine triphosphate
- HMGA2:
-
High-mobility group AT-hook 2
- HPG axis:
-
Hypothalamic-pituitary-gonadal axis
- IKBKG:
-
Inhibitor nuclear factor kappa B kinase subunit gamma
- IR:
-
Insulin resistance
- IVF:
-
In vitro fertilization
- LH:
-
Luteinising hormone
- LINE-1:
-
Long interspersed element
- MAPKs:
-
Mitogen-activated protein kinases
- MII:
-
Meiotic metaphase II
- MnSOD:
-
Mitochondrial SOD
- MPF:
-
Maturation-promoting factor
- mtDNA:
-
Mitochondrial DNA
- NAC:
-
N-acetyl-L-cysteine
- NAD+:
-
Nicotinamide adenine dinucleotide
- NF-κB:
-
Nuclear factor kappa B
- ORFs:
-
Open reading frame
- PCOS:
-
Polycystic ovary syndrome
- PDE3A:
-
Phosphodiesterase 3A
- PGC-1 α :
-
Proliferator-activated receptor coactivator-1α
- PGCs:
-
Primordial germ cells
- PI3K:
-
Phosphatidylinositol 3-kinase
- PTEN:
-
Phosphatase and tensin homolog
- RAB5B:
-
Ras-related protein Rab-5B
- RAGE:
-
Receptor for advanced glycation end products
- ROS:
-
Reactive oxygen species
- SDHA:
-
Subunit A of succinate dehydrogenase
- sFasL:
-
Soluble fasl
- SIRT1:
-
Silent information regulator-1
- SOD1:
-
Superoxide dismutase
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This work was supported by grant # 5300 from the Science and Technology. Development Fund.
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Ahmed, T.A. et al. (2019). Oocyte Aging: The Role of Cellular and Environmental Factors and Impact on Female Fertility. In: Turksen, K. (eds) Cell Biology and Translational Medicine, Volume 8. Advances in Experimental Medicine and Biology(), vol 1247. Springer, Cham. https://doi.org/10.1007/5584_2019_456
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