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Oxidative Stress Markers and Severity of Obstructive Sleep Apnea

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Pulmonology

Part of the book series: Advances in Experimental Medicine and Biology ((NR,volume 1222))

Abstract

Oxidative stress underlies both obstructive sleep apnea (OSA) and atherosclerosis. The aim of the study was to assess the markers of oxidative stress in plasma at different stages of OSA in non-smoking obese Caucasian males aged 41–60, with normal oral glucose tolerance test. All patients were subjected to clinical and polysomnographic examinations. The stage of OSA severity was set according to the following criteria of the apnea-hypopnea index (AHI): AHI < 5/h – no disease (OSA-0; n = 26), AHI 5–15/h – mild disease (OSA-1; n = 26), AHI 16–30/h – moderate disease (OSA-2: n = 27), and AHI > 30/h obstructive episodes per hour – severe disease (OSA-3; n = 27). Plasma total antioxidant status (TAS) and thiobarbituric acid-reacting substances (TBARS), reflecting the level of lipid peroxides, were determined spectrophotometrically. We found that TAS decreased and TBARS increased significantly from OSA-0 to OSA-3. We conclude that the oxidative stress markers are conducive to setting the severity of OSA in normoglycemic patients.

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Conflict of Interest

The authors declare no conflicts of interests in relation to this article.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the Ethics Committee of Poznań University of Medical Sciences in Poland.

Informed Consent

Written informed consent was obtained from all individual participants included in the study.

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Authors and Affiliations

  1. Department of Respiratory Medicine, Allergology and Pulmonary Oncology, Poznań University of Medical Sciences, Poznań, Poland

    S. Cofta, H. M. Winiarska, T. Piorunek & T. M. Kostrzewska

  2. Department of Laboratory Diagnostics, Poznań University of Medical Sciences, Poznań, Poland

    A. Płóciniczak, L. Bielawska & E. Wysocka

  3. Department of Clinical Biochemistry and Laboratory Medicine, Poznań University of Medical Sciences, Poznań, Poland

    A. Brożek

Authors
  1. S. Cofta
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  2. H. M. Winiarska
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  3. A. Płóciniczak
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  4. L. Bielawska
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  5. A. Brożek
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  6. T. Piorunek
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  7. T. M. Kostrzewska
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  8. E. Wysocka
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Corresponding author

Correspondence to S. Cofta .

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Editors and Affiliations

  1. Opole Medical School, Opole, Poland

    Mieczyslaw Pokorski

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Cofta, S. et al. (2019). Oxidative Stress Markers and Severity of Obstructive Sleep Apnea. In: Pokorski, M. (eds) Pulmonology. Advances in Experimental Medicine and Biology(), vol 1222. Springer, Cham. https://doi.org/10.1007/5584_2019_433

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