Abstract
Birth weight is a key determinant of perinatal outcomes which affect physical development and metabolic function. In this study, we evaluated the potential role of maternal body composition and nutritional status in programing fetal birth weight. This was a longitudinal study that included 29 pregnant women and their full-term newborns. Maternal dietary energy and fluid intake and body adipose tissue were assessed. In addition, we measured the serum content of copeptin, aldosterone, and angiotensin II in maternal and umbilical cord blood. The measurements were done across the three trimesters of pregnancy, on average, at 11.6 weeks, 18.3 weeks, and 30.2 weeks. Each newborn’s birth weight was determined at the percentile line, using the World Health Organization (WHO) standards based on the gestational age, gender, and weight. We found no appreciable relation of fetal birth weight to the maternal dietary and fluid intakes, and the content of angiotensin II, aldosterone, or copeptin. However, birth weight correlated with increases in body adipose tissue in early pregnancy stages. Further, birth weight correlated positively with copeptin and adversely with angiotensin II in cord blood. We conclude that the present findings may be helpful in the assessment of a critical level of body adipose tissue in women of child-bearing age, above which the potential risk of macrosomia appears. The female population of child-bearing age needs a continual update on the nutritional knowledge to prevent modifiable maternal and fetal perinatal complications.
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References
Abeysekera MV, Morris JA, Davis GK, O’Sullivan AJ (2016) Alterations in energy homeostasis to favour adipose tissue gain: a longitudinal study in healthy pregnant women. Aust N Z J Obstet Gynaecol 56:42–48
Alexander BT, Dasinger JH, Intapad S (2015) Fetal programming and cardiovascular pathology. Compr Physiol 5:997–1025
Bardosono S, Prasmusinto D, Hadiati DR, Purwaka BT, Morin C, Pohan R, Sunardi D, Chandra DN, Guelinckx I (2016) Fluid intake of pregnant and breastfeeding women in Indonesia: a cross-sectional survey with a seven-day fluid specific record. Nutrients 8:26–30
Barker DJ (1998) In utero programming of chronic disease. Clin Sci (Lond) 95:115–128
Bayard F, Ances IG, Tapper AJ, Weldon VV, Kowarski A, Migeon CJ (1970) Transplacental passage and fetal secretion of aldosterone. J Clin Invest 49:1389–1393
Beitins IZ, Bayard F, Levitsky L, Ances IG, Kowarski A, Migeon CJ (1972) Plasma aldosterone concentration at delivery and during the newborn period. J Clin Invest 51:386–394
Benzing J, Wellmann S, Achini F, Letzner J, Burkhardt T, Beinder E, Morgenthaler NG, Haagen U, Bucher HU, Buhrer C, Lapaire O, Szinnai G (2011) Plasma copeptin in preterm infants: a highly sensitive marker of fetal and neonatal stress. J Clin Endocrinol Metab 96:982–985
Briana DD, Baka S, Boutsikou M, Boutsikou T, Xagorari M, Gourgiotis D, Malamitsi–Puchner A (2016) Cord blood copeptin concentrations in fetal macrosomia. Metabolism 65:89–94
Briana DD, Boutsikou M, Boutsikou T, Dodopoulos T, Gourgiotis D, Malamitsi-Puchner A (2017) Plasma copeptin may not be a sensitive marker of perinatal stress in healthy full–term growth–restricted fetuses. J Matern Fetal Neonatal Med 30:705–709
Calkins K, Devaskar SU (2011) Fetal origins of adult disease. Curr Probl Pediatr Adolesc Health Care 41:158–176
Chou H, Wang L, Lu K, Chen C (2008) Effects of maternal undernutrition on renal angiotensin II and chymase in hypertensive offspring. Acta Histochem 110:497–504
Dufau ML, Villee DB (1969) Aldosterone biosynthesis by human fetal adrenal in vitro. Biochim Biophys Acta 176:637–640
Eriksson JG, Sandboge S, Salonen M, Kajantie E, Osmond C (2015) Maternal weight in pregnancy and offspring body composition in late adulthood: findings from the Helsinki Birth Cohort Study (HBCS). Ann Med 47:94–99
Guéant J, Namour F, Guéant–Rodriguez R, Daval JL (2013) Folate and fetal programming: a play in epigenomics? Trends Endocrinol Metab 24:279–289
Hulmán A, Witte DR, Kerenyi Z, Madarasz E, Tanczer T, Bosnyak Z, Szabo E, Ferencz V, Peterfalvi A, Tabak AG, Nyari TA (2015) Heterogeneous effect of gestational weight gain on birth weight: quantile regression analysis from a population–based screening. Ann Epidemiol 25:133–137
Institute of Medicine (US) and National Research Council (US) (2009) Committee to reexamine IOM pregnancy weight guidelines. In: Rasmussen KM, Yaktine AL (eds) Weight gain during pregnancy: reexamining the guidelines. National Academies Press (US), Washington, DC
Jarosz-Lesz A, Maruniak–Chudek I (2015) Copeptin – stable C–terminal fragment of pre–provasopressin as a new stress marker in newborns. Postepy Hig Med Dosw 69:681–689
Katz FH, Kappas A (1967) The effects of estradiol and estriol on plasma levels of cortisol and thyroid hormone-binding globulins and on aldosterone and cortisol secretion rates in man. J Clin Invest 46:1768–1777
Koch L, Dabek MT, Frommhold D, Poeschl J (2011) Stable precursor fragments of vasoactive peptides in umbilical cord blood of term and preterm infants. Horm Res Paediatr 76:234–239
Kwon EJ, Kim YJ (2017) What is fetal programming: a lifetime health is under the control of in utero health. Obstet Gynecol Sci 60:506–519
Larciprete G, Valensise H, Vasapollo B, Altomare F, Sorge R, Casalino B, De Lorenzo A, Arduini D (2003) Body composition during normal pregnancy: reference ranges. Acta Diabetol 40:225–232
Lukaszyk E, Malyszko J (2015) Copeptin: pathophysiology and potential clinical impact. Adv Med Sci 60:335–341
Martinerie L, Pussard E, Floix-l’He’Lias PF, Cosson C, Boileau P, Lombe’s M (2009) Physiological partial aldosterone resistance in human newborns. Pediatr Res 66(3):323–328
Morgenthaler NG, Struck J, Jochberger S, Dünser MW (2008) Copeptin: clinical use of a new biomarker. Trends Endocrinol Metab 19:43–49
Most J, Marlatt KL, Altazan AD, Redman LM (2018) Advances in assessing body composition during pregnancy. Eur J Clin Nutr 72:645–656
Mulyani EY, Hardinsyah, Briawan D, Santoso BI (2017) Hydration status of pregnant women in West Jakarta. Asia Pac J Clin Nutr 26:26–30
O’Connor C, O’Higgins AC, Segurado R, Turner MJ, Stuart B, Kennelly MM (2014) Maternal body composition and birth weight. Prenat Diagn 34:605–607
O’Higgins AC, Doolan A, McCartan T, Mullaney L, O’Connor C, Turner MJ (2018) Is birth weight the major confounding factor in the study of gestational weight gain?: an observational cohort study. BMC Pregnancy Childbirth 18:218
Robillard PY, Dekker G, Boukerrou M, Le Moullec N, Hulsey TC (2018) Relationship between pre–pregnancy maternal BMI and optimal weight gain in singleton pregnancies. Heliyon 4:e00615
Savard C, Lemieux S, Weisnagel SJ, Fontaine–Bisson B, Gagnon C, Robitaille J, Morisset AS (2018) Trimester-specific dietary intakes in a sample of French–Canadian pregnant women in comparison with national nutritional guidelines. Nutrients 10(6):768. https://doi.org/10.3390/nu10060768
Shephard RJ (1991) Body composition in biological anthropology. Cambridge University Press, Cambridge
Stout SA, Espel EV, Sandman CA, Glynn LM, Davis EP (2015) Fetal programming of children’s obesity risk. Psychoneuroendocrinology 53:29–39
Svitok P, Senko T, Panakova Z, Olexova L, Krskova L, Okuliarova M, Zeman M (2017) Prenatal exposure to angiotensin II increases blood pressure and decreases salt sensitivity in rats. Clin Exp Hypertens 39:489–494
Toro-Ramos T, Sichieri R, Hoffman DJ (2016) Maternal fat mass at mid–pregnancy and birth weight in Brazilian women. Ann Hum Biol 43:212–218
Traversa S, Martineriea L, Boileaue P, Xuea Q, Lombèsa M, Pussard E (2018) Comparative profiling of adrenal steroids in maternal and umbilical cord blood. J Steroid Biochem Mol Biol 178:127–134
Villar J, Ismail LC, Victora CG, Ohuma EO, Bertino E, Altman DG, Lambert A, Papageorghiou AT, Carvalho M, Jaffer YA, Gravett MG, Purwar M, Frederick IO, Noble AJ, Pang R, Barros FC, Chumlea C, Bhutta ZA, Kennedy SH (2014) International standards for newborn weight, length, and head circumference by gestational age and sex: the newborn cross–sectional study of the Intergrowth-21 Project. Lancet 384:857–868
Wang KC, Brooks DA, Summers–Pearce B, Bobrovskaya L, Tosh DN, Duffield JA, Botting KJ, Zhang S, IC MM, Morrison JL (2015) Low birth weight activates the renin–angiotensin system, but limits cardiac angiogenesis in early postnatal life. Physiol Rep 3:1–16
Wang Y, Mao J, Wang W, Qiou J, Yang L, Chen S (2017) Maternal fat free mass during pregnancy is associated with birth weight. Reprod Health 14:47
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The authors declare no conflicts of interest in relation to this article.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study protocol was approved by an institutional Ethics Committee.
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Written informed consent was obtained from all individual participants included in the study.
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Kozłowska, A. et al. (2019). Maternal Nutritional and Water Homeostasis as a Presage of Fetal Birth Weight. In: Pokorski, M. (eds) Advances in Biomedicine. Advances in Experimental Medicine and Biology(), vol 1176. Springer, Cham. https://doi.org/10.1007/5584_2019_389
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DOI: https://doi.org/10.1007/5584_2019_389
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