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Targeting Food Allergy with Probiotics

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Probiotics and Child Gastrointestinal Health

Part of the book series: Advances in Experimental Medicine and Biology ((AMIDPH,volume 1125))

Abstract

The dramatic increase in food allergy prevalence and severity globally is demanding effective strategies. Food allergy derives from a defect in immune tolerance mechanisms. Immune tolerance is modulated by gut microbiota composition and function, and gut microbiota dysbiosis has been associated with the development of food allergy. Selected probiotic strains could act on immune tolerance mechanisms. The mechanisms are multiple and still not completely defined. Increasing evidence is providing useful information on the choice of optimal bacterial species/strains, dosage, and timing for intervention. The increased knowledge on the crucial role played by gut microbiota-derived metabolites, such as butyrate, is also opening the way to a post-biotic approach in the stimulation of immune tolerance.

Authors Lorella Paparo, Rita Nocerino, Carmen Di Scala, Giusy Della Gatta and Margherita Di Costanzo have been equally contributed to this chapter.

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Abbreviations

BLG:

β-lactoglobulin

CMA:

cow’s milk allergy

EHCF:

extensively hydrolyzed casein formula

FA:

food allergy

LAB:

lactic acid bacteria

LGG:

Lactobacillus rhamnosus GG

OIT:

oral food immunotherapy

OVA:

ovalbumin

PBMCs:

peripheral blood mononuclear cells

SCFAs:

short-chain fatty acids

SU:

sustained unresponsiveness

Tregs:

regulatory T cells

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    Authors and Affiliations

    1. Department of Translational Medical Science, University of Naples “Federico II”, Naples, Italy

      Lorella Paparo, Rita Nocerino, Carmen Di Scala, Giusy Della Gatta, Margherita Di Costanzo, Cristina Bruno & Roberto Berni Canani

    2. CEINGE-Biotecnologie Avanzate s.c.ar.l., University of Naples “Federico II”, Naples, Italy

      Lorella Paparo, Rita Nocerino, Carmen Di Scala, Giusy Della Gatta, Margherita Di Costanzo, Aniello Buono & Roberto Berni Canani

    3. European Laboratory for the Investigation of Food-Induced Diseases, University of Naples “Federico II”, Naples, Italy

      Roberto Berni Canani

    4. Task Force on Microbiome Investigation, University of Naples Federico II, Naples, Italy

      Roberto Berni Canani

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    1. Lorella Paparo
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    Correspondence to Roberto Berni Canani .

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    Editors and Affiliations

    1. Department of Pediatrics, University of Chicago, Chicago, IL, USA

      Stefano Guandalini

    2. Department of Pediatrics, Ospedale Giovanni XXI, University of Bari Aldo Moro, Amendola, Bari, Italy

      Flavia Indrio

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    Paparo, L. et al. (2019). Targeting Food Allergy with Probiotics. In: Guandalini, S., Indrio, F. (eds) Probiotics and Child Gastrointestinal Health. Advances in Experimental Medicine and Biology(), vol 1125. Springer, Cham. https://doi.org/10.1007/5584_2018_316

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