Shaping Microbiota During the First 1000 Days of Life

Selma-Royo, Marta; Tarrazó, Maria; García-Mantrana, Izaskun; Gómez-Gallego, Carlos; Salminen, Seppo; Collado, Maria Carmen

doi:10.1007/5584_2018_312

Shaping Microbiota During the First 1000 Days of Life

Marta Selma-Royo⁶,
Maria Tarrazó⁷,
Izaskun García-Mantrana⁶,
Carlos Gómez-Gallego^8,9,
Seppo Salminen⁸ &
Maria Carmen Collado^6,8

Chapter
First Online: 26 January 2019

2575 Accesses
24 Citations
16 Altmetric

Part of the Advances in Experimental Medicine and Biology book series (AMIDPH,volume 1125)

Abstract

The data obtained in prior studies suggest that early microbial exposition begins prior to conception and gestation. Given that the host-microbe interaction is shaped by the immune system response, it is important to understand the key immune system-microbiota relationship during the period from conception to the first years of life. The present work summarizes the available evidence concerning early microbiota exposure within the male and the female reproductive tracts at the point of conception and during gestation, focusing on the potential impact on infant development during the first 1000 days of life. Furthermore, we conclude that some dietary strategies including specific probiotics could become potentially valuable tools to modulate the gut microbiota during this early critical window of opportunity for targeted health outcomes throughout the entire lifespan.

Keywords

Diet
Gestation
Health
Meconium
Microbiota
Placenta
Probiotics
Semen
Vagina

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Acknowledgements

Authors would like to acknowledge the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (ERC Starting Grant, project no. 639226). MSR would acknowledge the support from ACIF program of Generalitat Valenciana with European Social Fund (ESF).

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The authors declare that there are no conflicts of interest associated with the publication of this paper.

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Authors and Affiliations

Department of Biotechnology, Institute of Agrochemistry and Food Technology, Spanish National Research Council (IATA-CSIC), Valencia, Spain
Marta Selma-Royo, Izaskun García-Mantrana & Maria Carmen Collado
Service of Obstetrics and Gynecology, Hospital Universtario Doctor Peset, Valencia, Spain
Maria Tarrazó
Functional Foods Forum, University of Turku, Turku, Finland
Carlos Gómez-Gallego, Seppo Salminen & Maria Carmen Collado
Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
Carlos Gómez-Gallego

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Marta Selma-Royo
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Maria Tarrazó
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Izaskun García-Mantrana
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Seppo Salminen
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Maria Carmen Collado
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Correspondence to Maria Carmen Collado .

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Department of Pediatrics, University of Chicago, Chicago, IL, USA
MD Stefano Guandalini
Department of Pediatrics, Ospedale Giovanni XXI, University of Bari Aldo Moro, Amendola, Bari, Italy
MD Flavia Indrio

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Selma-Royo, M., Tarrazó, M., García-Mantrana, I., Gómez-Gallego, C., Salminen, S., Collado, M.C. (2019). Shaping Microbiota During the First 1000 Days of Life. In: Guandalini, S., Indrio, F. (eds) Probiotics and Child Gastrointestinal Health. Advances in Experimental Medicine and Biology(), vol 1125. Springer, Cham. https://doi.org/10.1007/5584_2018_312

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DOI: https://doi.org/10.1007/5584_2018_312
Published: 26 January 2019
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