Abstract
The data obtained in prior studies suggest that early microbial exposition begins prior to conception and gestation. Given that the host-microbe interaction is shaped by the immune system response, it is important to understand the key immune system-microbiota relationship during the period from conception to the first years of life. The present work summarizes the available evidence concerning early microbiota exposure within the male and the female reproductive tracts at the point of conception and during gestation, focusing on the potential impact on infant development during the first 1000 days of life. Furthermore, we conclude that some dietary strategies including specific probiotics could become potentially valuable tools to modulate the gut microbiota during this early critical window of opportunity for targeted health outcomes throughout the entire lifespan.
Keywords
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Acknowledgements
Authors would like to acknowledge the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (ERC Starting Grant, project no. 639226). MSR would acknowledge the support from ACIF program of Generalitat Valenciana with European Social Fund (ESF).
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The authors declare that there are no conflicts of interest associated with the publication of this paper.
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Selma-Royo, M., Tarrazó, M., García-Mantrana, I., Gómez-Gallego, C., Salminen, S., Collado, M.C. (2019). Shaping Microbiota During the First 1000 Days of Life. In: Guandalini, S., Indrio, F. (eds) Probiotics and Child Gastrointestinal Health. Advances in Experimental Medicine and Biology(), vol 1125. Springer, Cham. https://doi.org/10.1007/5584_2018_312
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