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Advances in Medicine and Medical Research pp 9–18Cite as

Coupling of Blood Pressure and Subarachnoid Space Oscillations at Cardiac Frequency Evoked by Handgrip and Cold Tests: A Bispectral Analysis

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Part of the book series: Advances in Experimental Medicine and Biology ((CLEXBI,volume 1133))

Abstract

The aim of the study was to assess blood pressure–subarachnoid space (BP–SAS) width coupling properties using time–frequency bispectral analysis based on wavelet transforms during handgrip and cold tests. The experiments were performed on a group of 16 healthy subjects (F/M; 7/9) of the mean age 27.2 ± 6.8 years and body mass index of 23.8 ± 4.1 kg/m2. The sequence of challenges was first handgrip and then cold test. The handgrip challenge consisted of a 2-min strain, indicated by oral communication from the investigator, at 30% of maximum strength. The cold test consisted of 2 min of hand immersion to approximately wrist level in cold water of 4 °C, verified by a digital thermometer. Each test was preceded by 10 min at baseline and was followed by 10-min recovery recordings. BP and SAS were recorded simultaneously. Three 2-min stages of the procedure, baseline, test, and recovery, were analyzed. We found that BP–SAS coupling was present only at cardiac frequency, while at respiratory frequency both oscillators were uncoupled. Handgrip and cold test failed to affect BP–SAS cardiac–respiratory coupling. We showed similar handgrip and cold test cardiac bispectral coupling for individual subjects. Further studies are required to establish whether the observed intersubject variability concerning the BP–SAS coupling at cardiac frequency has any potential clinical predictive value.

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Funding

The study was supported by the Medical University of Gdansk and the Medical University of Warsaw, Poland.

Conflicts of Interest

Drs. Andrzej F. Frydrychowski, Wojciech Guminski, and Pawel J. Winklewski are stakeholders in NIRTI SA, the producer of NIR-T/BSS subarachnoid space oscillation monitors. None of the other authors have any fiduciary interests in the research reported herein.

Ethical Approval

The experimental protocol of this study was approved by the Ethics Committee of the Medical University of Gdansk in Poland. All procedures performed in the study were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

Author information

Authors and Affiliations

  1. Department of Radiology Informatics and Statistics, Faculty of Health Sciences, Medical University of Gdansk, Gdansk, Poland

    Marcin Gruszecki & Agnieszka Gruszecka

  2. National Center for Hyperbaric Medicine, Faculty of Health Sciences, Medical University of Gdansk, Gdynia, Poland

    Yurii Tkachenko & Jacek Kot

  3. Department of Immunopathology of Infectious and Parasitic Diseases, Medical University of Warsaw, Warsaw, Poland

    Marek Radkowski

  4. Department of Quality of Life Research, Faculty of Health Sciences, Medical University of Gdansk, Gdansk, Poland

    Krzysztof Basiński

  5. Department of Clinical Anatomy and Physiology, Faculty of Health Sciences, Pomeranian University of Slupsk, Slupsk, Poland

    Monika Waskow & Pawel J. Winklewski

  6. Department of Computer Communications, Faculty of Electronics, Telecommunications and Informatics, Gdansk University of Technology, Gdansk, Poland

    Wojciech Guminski

  7. Department of Clinical Toxicology, Faculty of Health Sciences, Medical University of Gdansk, Gdansk, Poland

    Jacek Sein Anand

  8. Department of Biomedical Engineering, Faculty of Electronics, Telecommunications and Informatics, Gdansk University of Technology, Gdansk, Poland

    Jerzy Wtorek

  9. Department of Human Physiology, Faculty of Health Sciences, Medical University of Gdansk, Gdansk, Poland

    Andrzej F. Frydrychowski & Pawel J. Winklewski

  10. Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Warsaw, Poland

    Urszula Demkow

Authors
  1. Marcin Gruszecki
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  2. Yurii Tkachenko
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  3. Jacek Kot
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  4. Marek Radkowski
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  5. Agnieszka Gruszecka
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  6. Krzysztof Basiński
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  7. Monika Waskow
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  8. Wojciech Guminski
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  9. Jacek Sein Anand
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  10. Jerzy Wtorek
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  11. Andrzej F. Frydrychowski
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  12. Urszula Demkow
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  13. Pawel J. Winklewski
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Corresponding author

Correspondence to Urszula Demkow .

Editor information

Editors and Affiliations

  1. Opole Medical School, Opole, Poland

    Mieczyslaw Pokorski

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Gruszecki, M. et al. (2018). Coupling of Blood Pressure and Subarachnoid Space Oscillations at Cardiac Frequency Evoked by Handgrip and Cold Tests: A Bispectral Analysis. In: Pokorski, M. (eds) Advances in Medicine and Medical Research. Advances in Experimental Medicine and Biology(), vol 1133. Springer, Cham. https://doi.org/10.1007/5584_2018_283

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