Abstract
The aim of the study was to determine the level of antibodies against hemagglutinin of influenza viruses in the sera of 1,050 patients stratified into 7 different age groups during the 2016/2017 epidemic season in Poland. The method consisted of using the hemagglutination inhibition test (HAI). The findings confirmed the presence of anti-hemagglutinin antibodies against the following influenza virus antigens: A/California/7/2009 (H1N1) pdm09, A/Hong Kong/4801/2014 (H3N2), and B/Brisbane/60/2008. The level of anti-hemagglutinin antibodies differed across the age groups investigated, with the highest values in patients aged 10–14 years. We also found that the protection factor was highest for B/Brisbane/60/2008 antigen. It amounted to 72.7% in 10–14-year olds and to 69.3% in both 15–25 and 26–44-year olds. Taking into account a dismally low percentage of vaccinated population in the 2016/2017 epidemic season in Poland, amounting to barely 3.33%, the findings should be interpreted as representing the patients’ immune system response to influenza virus infection.
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Acknowledgments
Funded by NIPH-NIH thematic subject 3/EM. The authors acknowledge physicians and employees of VSESs participating in the sentinel and non-sentinel programs for their input into the influenza surveillance in Poland. We also thank the Malec Co for providing fertilized chicken embryos.
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The authors declare no conflicts of interest in relation to this article.
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Hallmann-Szelińska, E., Cieślak, K., Kowalczyk, D., Szymański, K., Brydak, L.B. (2018). Antibodies to Influenza Virus Hemagglutinin in the 2016/2017 Epidemic Season in Poland. In: Pokorski, M. (eds) Current Trends in Immunity and Respiratory Infections. Advances in Experimental Medicine and Biology(), vol 1108. Springer, Cham. https://doi.org/10.1007/5584_2018_232
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DOI: https://doi.org/10.1007/5584_2018_232
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