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Cell Biology and Translational Medicine, Volume 3 pp 73–89Cite as

Bioengineered Scaffolds for Stem Cell Applications in Tissue Engineering and Regenerative Medicine

Part of the Advances in Experimental Medicine and Biology book series (CBTMED,volume 1107)

Abstract

Stem cell-based therapies, harnessing the ability of stem cells to regenerate damaged or diseased tissues, are under wide-ranging consideration for regenerative medicine applications. However, limitations concerning poor cell persistence and engraftment upon cell transplantation still remain. During the recent years, several types of biomaterials have been investigated to control the fate of the transplanted stem cells, aiming to increase their therapeutic efficiency. In the present chapter we focus on the general properties of some of these biomaterials, which include polymers, ceramics, and nano-biomaterials. In the first part of the chapter, a brief explanation about stem cell biology, sources, and their microenvironment is provided. The second part of the chapter presents some of the most recent studies investigating different types of biomaterials and approaches that aim to mimic the stem cell microenvironment for a more precise control of the stem cell fate.

Keywords

  • Biomaterials
  • Regenerative medicine
  • Tissue engineering
  • Stem cells
  • Microenvironment

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  • DOI: 10.1007/5584_2018_215
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Abbreviations

3D:

Three-dimensional

ESCs:

Embryonic stem cells

IPSCs:

Induced pluripotent stem cells

HSCs:

Hematopoietic stem cells

SGZ:

Sub-granular zone

ECM:

Extracellular matrix

BM-MSCs:

Bone marrow mesenchymal stem cells

AFSC:

Amniotic fluid derived stem cells

ADSCs:

Adipose-derived stem cells

HA:

Hyaluronic acid

MMPs:

Metalloproteases

GAGs:

Glycosaminoglycans

PEG:

Poly (ethylene glycol)

PVA:

poly (vinyl alcohol)

PLA:

poly (lactic acid)

PLGA:

poly (lactic-co-glycolic acid)

PLC:

Polycaprolactone

BG:

Bioactive glass

CNTs:

Carbon nanotubes

DLC:

Diamond-like carbon

CNFs:

Carbon nanofibers

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Authors and Affiliations

  1. Cellular and Molecular Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran

    Maryam Rahmati & Masoud Mozafari

  2. Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran

    Maryam Rahmati & Masoud Mozafari

  3. Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), Tehran, Iran

    Maryam Rahmati & Masoud Mozafari

  4. Laboratory for Stem Cell Research, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark

    Cristian Pablo Pennisi

  5. The D-BOARD FP7 Consortium, Surrey, UK

    Ali Mobasheri

  6. The APPROACH IMI Consortium, Surrey, UK

    Ali Mobasheri

  7. Faculty of Health and Medical Sciences, University of Surrey, Surrey, UK

    Ali Mobasheri

  8. Arthritis Research UK Centre for Sport, Exercise and Osteoarthritis, Queen’s Medical Centre, Nottingham, UK

    Ali Mobasheri

  9. Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania

    Ali Mobasheri

Authors
  1. Maryam Rahmati
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  2. Cristian Pablo Pennisi
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  3. Ali Mobasheri
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  4. Masoud Mozafari
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Corresponding authors

Correspondence to Ali Mobasheri or Masoud Mozafari .

Editor information

Editors and Affiliations

  1. Ottawa Hospital Research Institute, Osgoode, ON, Canada

    Ph.D. Kursad Turksen

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Rahmati, M., Pennisi, C.P., Mobasheri, A., Mozafari, M. (2018). Bioengineered Scaffolds for Stem Cell Applications in Tissue Engineering and Regenerative Medicine. In: Turksen, K. (eds) Cell Biology and Translational Medicine, Volume 3. Advances in Experimental Medicine and Biology(), vol 1107. Springer, Cham. https://doi.org/10.1007/5584_2018_215

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