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Therapeutic Applications of Mesenchymal Stem Cells for Systemic Lupus Erythematosus
Mesenchymal stem cells (MSCs) have been intensively studied and applied in regenerative medicine and tissue engineering. Recently, their immune modulation functions make them as attractive potential approaches for autoimmune disease treatment. Systemic lupus erythematosus (SLE) is one type of chronic autoimmune diseases with multi-organ damaged by the immune system. Although current available treatments are effective for some patients, others are refractory for these therapies. The immuno-modulatory and regenerative characteristics of MSCs make them as one promising candidate for treating SLE. Thus, we would discuss their immune modulation effects, pre-clinical and clinical applications, and the potentials for immune tolerance re-establishment in SLE here.
KeywordsAutoimmune diseases Mesenchymal stem cells MSCs SLE Systemic lupus erythematosus
B cell activating factor
regulatory B cell
C-C motif chemokine ligand 2
hematopoietic stem cells
inducible nitric oxide synthase
mesenchymal stem cells
olfactory 1/early B cell factor-associated zinc-finger protein
systemic lupus erythematosus
follicular helper cell
transforming growth factor beta
T helper cells
tumor necrosis factor alpha
regulatory T cells
This work was supported by Natural Science Foundation of SZU (2017083), Natural Science Foundation of Shenzhen (JCYJ20170302152735071) and Medical Foundation of Guangdong (A2018308).
Conflict of Interest
The authors declare no commercial or financial conflict of interest.
The authors declare that this article does not contain any studies with human participants or animals.
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