Abstract
The incidence of chronic obstructive pulmonary disease (COPD) is on the rise worldwide. Chronic bronchitis is a frequent accompaniment of COPD, which increases the burden of COPD in affected individuals. The aim of this study was to characterize the phenotype of chronic bronchitis in COPD patients. The study was based on the survey data retrospectively retrieved from the Action Health–Lung Cancer Prophylaxis and Health Care Improvement screening program that concerned all the inhabitants, aged over 40, of the Proszowice administrative region situated in the Lesser Poland Voivodeship in southern Poland. Participants with the symptoms suggestive of a lung disease were subject to further evaluation. The findings were that 546 (13.3%) out of the 4105 individuals displayed spirometry features of COPD. Symptoms of chronic bronchitis were present in 92 (16.8%) out of the COPD afflicted persons. Chronic bronchitis was commoner in current smokers and its incidence increased with increasing severity of airway obstruction. In multivariate analysis, chronic bronchitis was independently related to lower FEV1, FVC, FEV1/FVC, and to dyspnea. In regression model, factors related to increased risk of chronic bronchitis were current smoking, asthma, and lower lung function. We conclude that COPD with coexisting chronic bronchitis is linked to severer dyspnea and worse lung function. Current smoking, asthma, and lower lung function are related to increased risk of chronic bronchitis accompanying COPD.
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References
Agusti A, Calverley PM, Celli B, Coxson HO, Edwards LD, Lomas DA, MacNee W, Miller BE, Rennard S, Silverman EK, Tal-Singer R, Wouters E, Yates JC, Vestbo J, Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators (2010) Characterisation of COPD heterogeneity in the ECLIPSE cohort. Respir Res 11:122
Buist AS, MA MB, Vollmer WM, Gillespie S, Burney P, Mannino DM, Menezes AM, Sullivan SD, Lee TA, Weiss KB, Jensen RL, Marks GB, Gulsvik A, Nizankowska-Mogilnicka E, BOLD Collaborative Research Group (2007) International variation in the prevalence of COPD (the BOLD study): a population-based prevalence study. Lancet 370:741–750
De Oca MM, Halbert RJ, Lopez MV, Perez-Padilla R, Tálamo C, Moreno D, Muiño A, Jardim JR, Valdivia G, Pertuzé J, Menezes AM (2012) The chronic bronchitis phenotype in subjects with and without COPD: the PLATINO study. Eur Respir J 40:28–36
Definition and classification of chronic bronchitis for clinical and epidemiological purposes. A report to the Medical Research Council by their Committee on the Aetiology of Chronic Bronchitis (1965) Lancet 1:775–779
Doney B, Hnizdo E, Graziani M, Kullman G, Burchfiel C, Baron S, Fujishiro K, Enright P, Hankinson JL, Stukovsky KH, Martin CJ, Donohue KM, Barr RG (2014) Occupational risk factors for COPD phenotypes in the multi-ethnic study of atherosclerosis (MESA) lung study. COPD 11:368–380
Ekberg-Aronsson M, Pehrsson K, Nilsson JA, Nilsson PM, Löfdahl CG (2005) Mortality in GOLD stages of COPD and its dependence on symptoms of chronic bronchitis. Respir Res 6:98
Fletcher C, Peto R (1977) The natural history of chronic airflow obstruction. BMJ 1:1645–1648
GOLD (2017) From the global strategy for the diagnosis, management and prevention of COPD, Global initiative for chronic obstructive lung disease. http://goldcopd.org. Accessed on 1 Feb 2017
Guerra S, Sherrill DL, Venker C, Ceccato CM, Halonen M, Martinez FD (2009) Chronic bronchitis before age 50 years predicts incident airflow limitation and mortality risk. Thorax 64:894–900
Halbert RJ, Natoli JL, Gano A, Badamgarav E, Buist AS, Mannino DM (2006) Global burden of COPD: systematic review and meta-analysis. Eur Respir J 28:523–532
Kanervisto M, Saarelainen S, Vasankari T, Jousilahti P, Heistaro S, Heliövaara M, Luukkaala T, Paavilainen E (2010) COPD, chronic bronchitis and capacity for day-to-day activities: negative impact of illness on the health-related quality of life. Chron Respir Dis 7:207–215
Kim V, Han MK, ance GB, Make BJ, Newell JD, Hokanson JE, Hersh CP, Stinson D, Silverman EK, Criner GJ, Investigators COPDG (2011) The chronic bronchitic phenotype of COPD: an analysis of the COPDGene study. Chest 140:626–633
Kim V, Zhao H, Boriek AM et al (2016) Persistent and newly developed chronic bronchitis are associated with worse outcomes in chronic obstructive pulmonary disease. Ann Am Thorac Soc 13:1016–1025
López-Campos JL, Tan W, Soriano JB (2016) Global burden of COPD. Respirology 21:14–23
Mahler DA, Wells CK (1988) Evaluation of clinical methods for rating dyspnea. Chest 93:580–586
Mejza F, Gnatiuc L, Buist AS, Vollmer WM, Lamprecht B, Obaseki DO, Nastalek P, Nizankowska-Mogilnicka E, Burney PGJ, collaborators BOLD, study collaborators BOLD (2017) Prevalence and burden of chronic bronchitis symptoms: results from the BOLD study. Eur Respir J 50(5):1700621
Nizankowska-Mogilnicka E, Mejza F, Buist AS, Vollmer WM, Skucha W, Harat R, Pajak A, Gasowski J, Frey J, Nastalek P, Twardowska M, Janicka J, Szczeklik A (2007) Prevalence of COPD and tobacco smoking in Malopolska region–results from the BOLD study in Poland. Pol Arch Med Wewn 117:402–410
Peto R, Speizer FE, Cochrane AL, Moore F, Fletcher CM, Tinker CM, Higgins IT, Gray RG, Richards SM, Gilliland J, Norman-Smith B (1983) The relevance in adults of air-flow obstruction, but not of mucus hypersecretion, to mortality from chronic lung disease. Results from 20 years of prospective observation. Am Rev Respir Dis 128:491–500
Postma DS, Rabe KF (2015) The asthma-copd overlap syndrome. N Engl J Med 373:1241–1249
Skucha W, Mejza F, Nastalek P, Doniec Z (2017) Pulmonary prevention program in the Proszowice county: description and results. Adv Respir Med 85:239–245
Stavem K, Sandvik L, Erikssen J (2006) Can global initiative for chronic obstructive lung disease stage 0 provide prognostic information on long-term mortality in men? Chest 130:318–325
US Preventive Services Task Force (USPSTF), Siu AL, Bibbins-Domingo K, Grossman DC, Davidson KW, Epling JW Jr, García FA, Gillman M, Kemper AR, Krist AH, Kurth AE, Landefeld CS, Mangione CM, Harper DM, Phillips WR, Phipps MG, Pignone MP (2016) Screening for chronic obstructive pulmonary disease: US preventive services task force recommendation statement. JAMA 315:1372–1377
Vestbo J, Prescott E, Lange P (1996) Association of chronic mucus hypersecretion with FEV1 decline and chronic obstructive pulmonary disease morbidity. Copenhagen City heart study group. Am J Respir Crit Care Med 153:1530–1535
Acknowledgments
Funded by Norway Grants – Program PL 13 entitled ‘Reducing social inequalities in health’. The founder played no role in planning and executing this study.
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The authors declare no conflicts of interest in relation to this article.
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Mejza, F., Nastałek, P., Mastalerz-Migas, A., Doniec, Z., Skucha, W. (2018). Coexistence of Chronic Bronchitis in Chronic Obstructive Lung Disease. In: Pokorski, M. (eds) Clinical Pulmonary Research. Advances in Experimental Medicine and Biology(), vol 1114. Springer, Cham. https://doi.org/10.1007/5584_2018_200
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DOI: https://doi.org/10.1007/5584_2018_200
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