Hospital Morbidity Database for Epidemiological Studies on Churg-Strauss Syndrome
Churg-Strauss syndrome or more accurately eosinophilic granulomatosis with polyangiitis (EGPA) is a small-vessel necrotizing vasculitis with a characteristic late-onset allergic rhinitis and asthma. The use of hospital morbidity database is an important element of the epidemiological analysis of this rare disease. The present study was undertaken to assess the incidence of EGPA and factors related to its epidemiology in Poland; the first analysis of the kind in Poland, enabling a comparison in the European context. This is a retrospective, population-based study using hospital discharge records with EGPA diagnosis, collected for a National Institute of Public Health survey covering the period from 2008 to 2013. The group consisted of 344 patients (206 females and 138 males) with the first-time hospitalization for EGPA. The major findings are that the annual incidence of EGPA in Poland was 1.5 per million (95% confidence intervals: 1.2–1.8), with the point prevalence of 8.8 per million at the end of 2013. A greater incidence of EGPA was observed in the regions with urban predominance. We conclude that discharge records may be a useful element of epidemiological studies on EGPA.
KeywordsANCA-associated Disease prevalence Eosinophilic granulomatosis Epidemiology Morbidity Polyangiitis Vasculitis
Conflicts of Interest
Authors declare no conflict of interest in relation to this article.
- Central Statistical Office of Poland. http://stat.gov.pl. Accessed 13 Oct 2016
- Comarmond C, Pagnoux C, Khellaf M, Cordier JF, Hamidou M, Viallard JF, Maurier F, Jouneau S, Bienvenu B, Puéchal X et al (2013) Eosinophilic granulomatosis with polyangiitis (Churg-Strauss): clinical characteristics and long-term followup of the 383 patients enrolled in the French Study Group cohort. Arthritis Rheum 65:270–281CrossRefPubMedGoogle Scholar
- Groh M, Pagnoux C, Baldini C, Bel E, Bottero P, Cottin V, Dalhoff K, Dunogué B, Gross W, Holle J et al (2015) Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA) Consensus Task Force recommendations for evaluation and management. Eur J Intern Med 26:545–553CrossRefPubMedGoogle Scholar
- HMDB (2016) European Hospital Morbidity Database. Copenhagen, WHO Regional Office for Europe. http://www.euro.who.int/en/data-and-evidence/databases/european-hospital-morbidity-database-hmdb2. Accessed on 16 Oct 2016
- Masi AT, Hunder GG, Lie JT, Michel BA, Bloch DA, Arend WP, Calabrese LH, Edworthy SM, Fauci AS, Leavitt RY (1990) The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis). Arthritis Rheum 33:1094–1100CrossRefPubMedGoogle Scholar
- Phillip R, Luqmani R (2008) Mortality in systemic vasculitis: a systematic review. Clin Exp Rheumatol 26(5 Suppl 51):94–104Google Scholar
- Romero-Gomez C, Aguilar-Garcia JA, Garcia-de-Lucas MD, Cotos-Canca R, Olalla-Sierra J, Garcia-Alegria JJ, Hernández-Rodríguez J (2015) Epidemiological study of primary systemic vasculitides among adults in southern Spain and review of the main epidemiological studies. Clin Exp Rheumatol 33(2 Suppl 89):11–18Google Scholar
- Sada KE, Amano K, Uehara R, Yamamura M, Arimura Y, Nakamura Y, Makino H, Research Committee on Intractable Vasculitides, the Ministry of Health, Labour, Welfare of Japan (2014) A nationwide survey on the epidemiology and clinical features of eosinophilic granulomatosis with polyangiitis (Churg-Strauss) in Japan. Mod Rheumatol 24:640–644CrossRefPubMedGoogle Scholar
- Sokolowska BM, Szczeklik WK, Wludarczyk AA, Kuczia PP, Jakiela BA, Gasior JA, Bartyzel SR, Rewerski PA, Musial J (2014) ANCA-positive and ANCA-negative phenotypes of eosinophilic granulomatosis with polyangiitis (EGPA): outcome and long-term follow-up of 50 patients from a single Polish center. Clin Exp Rheumatol 32(3 Suppl 82):41–47Google Scholar
- Vinit J, Muller G, Bielefeld P, Pfitzenmeyer P, Bonniaud P, Lorcerie B, Besancenot JF (2011) Churg-Strauss syndrome: retrospective study in Burgundian population in France in past 10 years. Rheumat Int 31:587–593Google Scholar