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Protein Reviews pp 71–89Cite as

P2Y1 Receptors – Properties and Functional Activities

Part of the Advances in Experimental Medicine and Biology book series (PROTRE,volume 1051)

Abstract

In this chapter we try to show a comprehensive image of current knowledge of structure, activity and physiological role of the P2Y1 purinergic receptor. The structure, distribution and changes in the expression of this receptor are summarized, as well as the mechanism of its signaling activity by the intracellular calcium mobilization. We try to show the connection between the components of its G protein activation and cellular or physiological effects, starting from changes in protein phosphorylation patterns and ending with such remote effects as receptor-mediated apoptosis. The special emphasis is put on the role of the P2Y1 receptor in cancer cells and neuronal plasticity. We concentrate on the P2Y1 receptor, it is though impossible to completely abstract from other aspects of nucleotide signaling and cross-talk with other nucleotide receptors is here discussed. Especially, the balance between P2Y1 and P2Y12 receptors, sharing the same ligand but signaling through different pathways, is presented.

Keywords

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Abbreviations

AC:

Adenylate cyclase

Akt:

Protein kinase B/Akt kinase

[Ca2+]:

Intracellular calcium concentration

CA1:

Cornu Ammonis area 1

CA3:

Cornu Ammonis area 3

DAG:

Diacylglycerol

ER:

Endoplasmic reticulum

ERK1/2:

Extracellular signal-regulated kinases 1/2

GABA:

γ-Aminobutyric acid

IP3 :

Inositol-1,4,5-trisphosphate

LTD:

Long term depression

mGluR:

Metabotropic glutamate receptor

2MeSADP:

2-Methylthio ADP

MRS2365:

(N)-Methanocarba 2MeSADP

NMDA:

N-Methyl-D-aspartic acid

NR2B:

NMDA receptor subtype 2B

PI3K:

Phosphatidylinositol 3-kinase

PIP2 :

Phosphatidylinositol-4,5-bisphosphate

PIP3 :

Phosphatidylinositol-3,4,5-trisphosphate

PKC:

Protein kinase C

PLC:

Phospholipase C

PMCA:

Plasma membrane calcium pump

PPADS:

Pyridoxal-phosphate-6-azophenyl-2′,4′disulfonic acid

PTEN:

3-Phosphatase and tensin homolog

SOCE:

Store-operated calcium entry

STIM1:

Stromal interaction molecule

TM:

Transmembrane domain

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Authors clearly state that no data present in this manuscript creates any conflict of interest for any of coauthors. The article is an review and do not contain any experimental data which could violate any standards of animal or human participation in studies.

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Authors and Affiliations

  1. Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., PL 02-093, Warsaw, Poland

    Jolanta Barańska

  2. Laboratory of Spatial Memory, Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., PL 02-093, Warsaw, Poland

    Rafał Czajkowski

  3. Laboratory of Molecular Basis of Cell Motility, Department of Cell Biochemistry, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., PL 02-093, Warsaw, Poland

    Paweł Pomorski

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  1. Jolanta Barańska
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  2. Rafał Czajkowski
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  3. Paweł Pomorski
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Correspondence to Paweł Pomorski .

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  1. Biochem and Mol Biol, Baylor College of Medicine, Houston, Texas, USA

    M. Zouhair Atassi

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Barańska, J., Czajkowski, R., Pomorski, P. (2017). P2Y1 Receptors – Properties and Functional Activities. In: Atassi, M. (eds) Protein Reviews. Advances in Experimental Medicine and Biology(), vol 1051. Springer, Singapore. https://doi.org/10.1007/5584_2017_57

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