Evaluation of Immune Indices and Serum Vitamin D Content in Children with Atopic Dermatitis

  • Agnieszka Lipińska-OpałkaEmail author
  • Agata Wawrzyniak
  • Sławomir Lewicki
  • Robert Zdanowski
  • Bolesław Kalicki
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1020)


The influence of vitamin D on allergic diseases, including atopic dermatitis, is linked to the presence of vitamin D nuclear receptors in immune cells. The present study seeks to determine the possible relationship between serum vitamin D content and immune indices in children with atopic dermatitis. The study was conducted in 19 children with atopic dermatitis. The control consisted of 17 age-matched healthy children. A single significant finding was a distinctly lower number of serum regulatory T cells in atopic dermatitis compared with controls (p < 0.00001). There were no appreciable differences between the two groups concerning the immunological indices such as the phenotypes: CD3, CD4, CD8, CD4/CD8, CD19, CD16/56, natural killer T cells, and anti-CD3 human leukocyte antigen – antigen D related cell surface receptor (HLA-DR3), or the percentage of lymphocytes, eosinophils, and the IgE level. We also revealed an inverse association between the serum vitamin D and the percentage of CD8+ cells (p < 0.05; r = 0.62) in atopic dermatitis. In conclusion, the results point to a regulatory role of T cells in the pathogenesis of atopic dermatitis, but fail to substantiate the influence of vitamin D on the course of the disease.


Allergy Atopic dermatitis Children Regulatory T cells Vitamin D 



The authors thank Mr. Piotr Murawski, Head of ICT Department, of the Military Institute of Medicine for assistance in the implementation of statistical analysis. The authors also thank the study participants and their parents. Supported by grant 1/8865 (323) of the Military Institute of Medicine.

Conflicts of Interest

The authors declare no competing interests in relation to this article.


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Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  • Agnieszka Lipińska-Opałka
    • 1
    Email author
  • Agata Wawrzyniak
    • 1
  • Sławomir Lewicki
    • 2
  • Robert Zdanowski
    • 2
  • Bolesław Kalicki
    • 1
  1. 1.Pediatric, Nephrology and Allergology ClinicMilitary Institute of MedicineWarsawPoland
  2. 2.Department of Regenerative Medicine and Cell BiologyMilitary Institute of Hygiene and EpidemiologyWarsawPoland

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