Abstract
Hepatocyte growth factor (HGF) is involved in tumorigenesis, interleukin-20 (IL-20) is an inhibitor of angiogenesis, and interleukin-22 (IL-22) stimulates tumor growth. The aim of this study was to determine the level of HGF, IL-20, and IL-22 in both serum and bronchoalveolar lavage fluid (BALF) of non-small cell lung cancer (NSCLC) patients before onset of chemotherapy, the nature of the interrelationships between these markers, and their prognostic significance regarding post-chemotherapy survival time. We studied 46 NSCLC patients and 15 healthy subjects as a control group. We found significantly higher serum levels of HGF and IL-22 in the NSCLC patients than those in controls [pg/ml: HGF – 1911 (693–6510) vs. 1333 (838–3667), p = 0.0004; IL-22 – 10.66 (1.44–70.34) vs. 4.69 (0.35–12.29), p = 0.0007]. In contrast, concentrations of HGF and IL-22 in BALF were lower in NSCLC patients than those in controls [pg/ml: HGF – 72 (6–561) vs. 488 (14–2003), p = 0.0002; IL-22 – 2.28 (0.70–6.52) vs. 3.72 (2.76–5.64), p = 0.002]. In the NSCLC patients, there was a negative correlation between the serum level of IL-20 and time to tumor progression (r = −0.405, p = 0.04) and between the serum level of HGF and survival time (r = −0.41, p = 0.005). In addition, a higher serum level of HGF and a higher BALF level of IL-22 in patients were linked with a shorter overall survival. We conclude that HGF, IL-20, and IL-22 in the serum and BALF of NSCLC patients before chemotherapy may be a prognostic of cancer progression.
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Naumnik, W., Naumnik, B., Niklińska, W., Ossolińska, M., Chyczewska, E. (2016). Clinical Implications of Hepatocyte Growth Factor, Interleukin-20, and Interleukin-22 in Serum and Bronchoalveolar Fluid of Patients with Non-Small Cell Lung Cancer. In: Pokorski, M. (eds) Advancements in Clinical Research. Advances in Experimental Medicine and Biology(), vol 952. Springer, Cham. https://doi.org/10.1007/5584_2016_66
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DOI: https://doi.org/10.1007/5584_2016_66
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