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Fungal Biofilms and related infections pp 1–11Cite as

Aspergillus Biofilms in Human Disease

Part of the Advances in Experimental Medicine and Biology book series (AMIDPH,volume 931)

Abstract

The biofilm phenotype of Aspergillus species is an important and accepted clinical entity. While industrially these biofilms have been used extensively in important biofermentations, their role in clinical infection is less well defined. A recent flurry of activity has demonstrated that these interesting filamentous moulds have the capacity to form biofilms both in vitro and in vivo, and through various investigations have shown that these are exquisitely resistant to antifungal therapies through a range of adaptive resistance mechanisms independent of defined genetic changes. This review will explore the clinical importance of these biofilms and provide contemporary information with respect to their clinical management.

Keywords

  • Aspergillus biofilm
  • Filamentous moulds
  • Fungal infections
  • Aspergillosis
  • Antifungal drugs

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Authors and Affiliations

  1. Institute of Healthcare Policy and Practice, University of West of Scotland, High St, Paisley, PA1 2BE, UK

    Craig Williams

  2. Infection and Immunity Research Group, Glasgow Dental School and Hospital, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland

    Ranjith Rajendran & Gordon Ramage

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  1. Craig Williams
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  2. Ranjith Rajendran
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  3. Gordon Ramage
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Correspondence to Craig Williams .

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Editors and Affiliations

  1. Laboratory Ecology & Biology of Interactions UMR CNRS 7267, University of Poitiers, Poitiers, France

    Christine Imbert

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Williams, C., Rajendran, R., Ramage, G. (2016). Aspergillus Biofilms in Human Disease. In: Imbert, C. (eds) Fungal Biofilms and related infections. Advances in Experimental Medicine and Biology(), vol 931. Springer, Cham. https://doi.org/10.1007/5584_2016_4

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