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Rarity of Mixed Species Malaria with Plasmodium falciparum and Plasmodium malariae in Travelers to Saarland in Germany

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Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 944)

Abstract

Malaria is an acute, life-threatening infectious disease that spreads in tropical and subtropical regions. Malaria is mainly brought over to Germany by travelers, so the disease can be overlooked due to its nonspecific symptoms and a lack of experience of attending physicians. The aim of this study was to analyze, retrospectively, epidemiological and clinical data from patients examined for malaria. Patient data were collected from hospital charts at the Department of Internal Medicine, Saarland University Medical Center, Germany, for the period of 2004–2012. The data of patients with and without malaria were compared in terms of their epidemiological, demographic, clinical, and medical treatment aspects. We identified found 15 patients with malaria (28.3 %, mean age 42.3 ± 16.5 years, three females [20 %]; 95 % confidence interval of 0.2–0.4) out of the 53 patients examined. Mainly locals brought malaria over to Homburg, Germany (p = 0.009). Malaria tropica was the most common species (p < 0.0001). One patient (6.7 %) with malaria, who had recently traveled, had a mixed infection of Plasmodium falciparum and Plasmodium malariae (p = 0.670). Malaria is characterized by thrombocytopenia (p = 0.047) and elevated C-reactive protein (p = 0.019) in serum, and fever is the leading symptom (p = 0.031). In most cases, malaria was brought from Ghana (33.3 %). Further, patients had contracted malaria despite malaria prophylaxis (33.3 %, p = 0.670). In conclusion, malaria test should be used in patients with fever after a journey from Africa. Malaria caused by Plasmodium falciparum is the most common species of brought over malaria. Mixed-species Plasmodium falciparum and Plasmodium malariae are uncommon in travelers with malaria.

Keywords

Malaria parasites Malaria symptoms Malaria treatment Mosquito Prophylaxis Traveler malaria Tropical disease 
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Notes

Conflicts of Interest

The authors report no conflicts of interest in relation to this article.

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Department of Internal Medicine, Division of Pulmonary, Allergy, and Sleep MedicineSaarland University Medical CenterHomburg/SaarGermany
  2. 2.Department of Internal Medicine, Division of Pulmonary, Allergy and Sleep MedicineHELIOS Clinic Wuppertal, Witten/Herdecke UniversityWittenGermany

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