Advertisement

Pertussis: History of the Disease and Current Prevention Failure

  • E. KucharEmail author
  • M. Karlikowska-Skwarnik
  • S. Han
  • A. Nitsch-Osuch
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 934)

Abstract

Pertussis or whooping cough has been given many names over the centuries. It was first recognized in the Middle Ages and since then various epidemics have been described. Jules Bordet and Octave Gengou isolated Bordetella pertussis, a causative agent for whooping cough, in Paris more than 100 years ago, which created an excellent opportunity to invent a vaccine. In 1914 the whole-cell pertussis vaccine was invented, then in the 1940s it was combined with tetanus and diphtheria toxoids to become DTP and it became widely available. A successive decrease in the incidence of the disease has since been observed. The vaccine has been about 80 % effective in preventing serious disease and death from pertussis. The disadvantage is that the vaccine offers protection for 5–10 years after the last dose of the full vaccination course. The second issue is the question of how to prevent side effects of the whole-cell vaccine. In the 1990s, the acellular vaccine was introduced in the US and gradually replaced the whole-cell vaccine. About 10 years later, a possible failure with the new vaccine has been observed, that is a lack of long-term protection. Nowadays, both vaccines are used, with the acellular vaccine being vastly predominant in most developed countries. Pertussis incidence has increased since the 1980s, but new prevention strategies include booster doses for specific age groups.

Keywords

Infection Immunization Pertussis vaccine Prevention Prophylaxis Whooping cough 

Notes

Conflicts of Interest

The authors declare no conflicts of interest in relation to this article.

References

  1. ACIP (1992) Pertussis vaccination: acellular pertussis vaccine for reinforcing and booster use – Supplementary ACIP statement recommendations of the immunization practices advisory committee. MMRW Rec Rep Feb. 07, 1992/41 (RR-1); 1–10. Available from: http://www.cdc.gov/mmwr/preview/mmwrhtml/00041801.htm. Accessed on 5 Feb 2016
  2. ACIP (1997) Pertussis vaccination: use of acellular pertussis vaccines among infants and young children recommendations of the Advisory Committee on Immunization Practices (ACIP) MMRW Rec and Rep March 28, 1997/46 (RR-7); 1–25. Available from: http://www.cdc.gov/mmwr/preview/mmwrhtml/00048610.htm. Accessed on 5 Feb 2016
  3. Bouchez V, Brun D, Cantinelli T, Dore G, Njamkepo E, Guiso N (2009) First report and detailed characterization of B. pertussis isolates not expressing Pertussis Toxin or Pertactin. Vaccine 27:6034–6041CrossRefPubMedGoogle Scholar
  4. Bouchez V, Hegerle N, Strati F, Njamkepo E, Guiso N (2015) New data on vaccine antigen deficient Bordetella pertussis isolates. Vaccine 14:751–770CrossRefGoogle Scholar
  5. Broder KR, Cortese MM, Iskander JK, Kretsinger K, Slade BA, Brown KH, Mijalski CM, Tiwari T, Weston EJ, Cohn AC, Srivastava PU, Moran JS, Schwartz B, Murphy TV, Advisory Committee on Immunization Practices (ACIP) (2006) Advisory Committee on Immunization Practices (ACIP) Preventing tetanus, diphtheria, and pertussis among adolescents: use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccines recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 55(RR-3):1–34Google Scholar
  6. Cherry JD (2010) The present and future control of pertussis. Clin Infect Dis 51(6):663–667CrossRefPubMedGoogle Scholar
  7. Cherry JD, Brunnel PA, Golden GS, Karzon DT (1988) Report of the task force on pertussis and pertussis immunization – 1988. Pediatrics 81:933–984Google Scholar
  8. Dauer CC (1943) Reported whooping cough morbidity and mortality in the United States. Public Health Rep 58:661–676CrossRefGoogle Scholar
  9. ECDC (2014) European Center for Disease Prevention and Control. Annual epidemiological report 2014 – vaccine-preventable diseases. Available from: http://ecdc.europa.eu/en/publications/Publications/AER-2014-VPD-FINAL.pdf. Accessed on 5 Feb 2016
  10. Guiso N (2014) Bordetella pertussis: why is it still circulating? J Infect 68:S119–S124CrossRefPubMedGoogle Scholar
  11. Gustafsson L, Hessel L, Storsaeter J, Olin P (2006) Long-term follow-up of Swedish children vaccinated with acellular pertussis vaccines at 3, 5, and 12 months of age indicates the need for a booster dose at 5 to 7 years of age. Pediatrics 118:978–984CrossRefPubMedGoogle Scholar
  12. Klein NP (2014) Licensed pertussis vaccines in the United States. History and current state. Hum Vaccin Immunother 10:2684–2690CrossRefPubMedGoogle Scholar
  13. Klein NP, Bartlett J, Fireman B, Rowhani-Rahbar A, Baxter R (2013) Comparative effectiveness of acellular versus whole-cell pertussis vaccines in teenagers. Pediatrics 131:e1716–e1722CrossRefPubMedGoogle Scholar
  14. Lynfield R, Schaffner W (2014) Can we conquer coqueluche? J Infect Dis 209(Suppl 1):S1–S3. doi: 10.1093/infdis/jit487 CrossRefPubMedGoogle Scholar
  15. Miranda C, Porte L, García P (2012) Bordetella holmesii in nasopharyngeal samples from Chilean patients with suspected Bordetella pertussis infection. J Clin Microbiol 50:1505CrossRefPubMedPubMedCentralGoogle Scholar
  16. Morgan LG (1997) Pertussis immunization: an update. J Can Chiropr Assoc 41(2):86–90Google Scholar
  17. Olin P, Gustafsson L, Barreto L, Hessel L, Mast TC, Rie AV, Bogaerts H, Storsaeter J (2003) Declining pertussis incidence in Sweden following the introduction of acellular pertussis vaccine. Vaccine 21:2015–2021CrossRefPubMedGoogle Scholar
  18. Romanus V, Jonsell R, Bergquist SO (1987) Pertussis in Sweden after the cessation of general immunization in 1979. Pediatr Infect Dis J 6:364–671CrossRefPubMedGoogle Scholar
  19. Rucker WC (1912) Whooping cough, its nature and prevention: a popular discussion of a widespread and dangerous disease for which familiarity has bred. Contempt Public Health Rep 27:1736–1739CrossRefGoogle Scholar
  20. Sato Y, Sato H (1999) Development of acellular pertussis vaccines. Biologicals 27:61–69CrossRefPubMedGoogle Scholar
  21. Sheridan SL, Ware R, Grimwood K, Lambert SB (2012) Number and order of whole cell pertussis vaccines in infancy and disease protection. JAMA 308:454–456CrossRefPubMedGoogle Scholar
  22. Tan T, Dalby T, Forsyth K, Halperin SA, Heininge U, Hozbor D, Plotkin S, Ulloa-Gutierrez R, von König CH (2015) Pertussis across the globe: recent epidemiologic trends from 2000–2013. Pediatr Infect Dis J 34:e222–e232CrossRefPubMedGoogle Scholar
  23. Weston R (2012) Whooping cough: a brief history to the 19th century. Can Bull Med Hist/Bulletin canadien d’histoire de la médecine 29:329–349Google Scholar
  24. WHO/UNICEF (2015) Global immunization data. Available from: http://www.who.int/immunization/monitoring_surveillance/Global_Immunization_Data.pdf?ua=. Accessed on 5 Feb 2016
  25. Wood N, McIntyre P, Marshall H, Roberton D (2010) Acellular pertussis vaccine at birth and one month induces antibody responses by two months of age. Pediatr Infect Dis J 29:209–215CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • E. Kuchar
    • 1
    Email author
  • M. Karlikowska-Skwarnik
    • 2
  • S. Han
    • 3
  • A. Nitsch-Osuch
    • 4
  1. 1.Department of Pediatrics with Clinical Assessment Unit, Second Medical FacultyMedical University of WarsawWarsawPoland
  2. 2.Department of Pediatric Infectious DiseasesMedical University of WroclawWroclawPoland
  3. 3.Department of Industrial PharmacyMedical University of WroclawWroclawPoland
  4. 4.Department of Family MedicineMedical University of WarsawWarsawPoland

Personalised recommendations