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Cardiac Vagal Control and Depressive Symptoms in Response to Negative Emotional Stress

  • I. Tonhajzerova
  • Z. Visnovcova
  • A. Mestanikova
  • A. Jurko
  • M. MestanikEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 934)

Abstract

We aimed to study complex cardiovagal control using heart rate variability (HRV), linear and nonlinear analyses at rest and during negative emotional stress in healthy students with varying depressive symptoms. ECG recording in 20 students was performed at baseline, negative emotional stress, and recovery period. The HRV parameters evaluated were the following: RR interval, spectral power in high-frequency band (HF-HRV), and symbolic dynamics index 2LV%. The subjects were divided into two groups based on the score of the Beck Depression Inventory (BDI) – normal mood (BDI: 0.6 ± 0.2) and mild mood disturbance (BDI: 14.3 ± 1.4). We found significantly lower logHF-HRV during emotional stress in mild mood disturbance compared with normal mood (p = 0.047). No significant differences were found in the remaining parameters. We conclude that negative emotional stress attenuated the cardiovagal control during mood disturbance, which points to discrete abnormalities in the neurocardiac reflex system associated with depressive symptoms. Hampered cardiovagal control could represent a potential pathomechanism leading to depression-linked cardiovascular complications.

Keywords

Depression Emotion Heart rate variability Mood disturbance Neurocardiac regulation Stress 

Notes

Acknowledgments

This work was supported by National Research Grant VEGA 1/0087/14, Comenius University Grant UK/151/2016, and the project “Biomedical Center Martin” ITMS code: 26220220187, the project is co-financed from EU sources.

Conflicts of Interest

The authors declare no conflicts of interest in relation to this article.

References

  1. Beck AT, Steer RA (1993) Manual for the Beck depression inventory. The Psychological Corporation, San AntonioGoogle Scholar
  2. Blom EH, Olsson EM, Serlachius E, Ericson M, Ingvar M (2010) Heart rate variability (HRV) in adolescent females with anxiety disorders and major depressive disorder. Acta Paediatr 99:604–611CrossRefGoogle Scholar
  3. Blood JD, Wu J, Chaplin TM, Hommer R, Vazquez L, Rutherford HJ, Mayes LC, Crowley MJ (2015) The variable heart: high frequency and very low frequency correlates of depressive symptoms in children and adolescents. J Affect Disord 186:119–126CrossRefPubMedGoogle Scholar
  4. Brinkmann K, Gendolla GHE (2008) Does depression interfere with effort mobilization? Effects of dysphoria and task difficulty on cardiovascular response. J Pers Soc Psychol 94:147–157CrossRefGoogle Scholar
  5. Bylsma LM, Morris BH, Rottenberg J (2008) A meta-analysis of emotional reactivity in major depressive disorder. Clin Psychol Rev 28:676–691CrossRefPubMedGoogle Scholar
  6. Fiedorowicz JG (2014) Depression and cardiovascular disease: an update on how course of illness may influence risk. Curr Psychiatry Rep 16:492CrossRefPubMedPubMedCentralGoogle Scholar
  7. Hawkins MA, Stewart JC, Fitzgerald GJ, Kim S (2011) Combined effect of depressive symptoms and hostility on autonomic nervous system function. Int J Psychophysiol 81:317–323CrossRefPubMedGoogle Scholar
  8. Lovallo WR (2011) Do low levels of stress reactivity signal poor states of health? Biol Psychol 86:121–128CrossRefPubMedGoogle Scholar
  9. Matthews SC, Nelesen RA, Dimsdale JE (2005) Depressive symptoms are associated with increased systemic vascular resistance to stress. Psychosom Med 67:509–513CrossRefPubMedGoogle Scholar
  10. Park G, Thayer JF (2014) From the heart to the mind: cardiac vagal tone modulates top-down and bottom–up visual perception and attention to emotional stimuli. Front Psychol 5:278Google Scholar
  11. Pichon A, Nuissier F, Chapelot D (2010) Heart rate variability and depressed mood in physical education students: a longitudinal study. Auton Neurosci 156:117–123CrossRefPubMedGoogle Scholar
  12. Porges SW (1995) Orienting in a defensive world: mammalian modifications of our evolutionary heritage. A polyvagal theory. Psychophysiology 32:301–318Google Scholar
  13. Porges SW (2007) A phylogenetic journey through the vague and ambiguous Xth cranial nerve: a commentary on contemporary heart rate variability research. Biol Psychol 74:301–307CrossRefPubMedGoogle Scholar
  14. Porta A, Guzzetti S, Montano N, Furlan R, Pagani M, Malliani A, Cerutti S (2001) Entropy, entropy rate, and pattern classification as tools to typify complexity in short heart period variability series. IEEE Trans Biomed Eng 48:1282–1291CrossRefPubMedGoogle Scholar
  15. Porta A, Faes L, Masé M, D’Addio G, Pinna GD, Maestri R, Montano N, Furlan R, Guzzetti S, Nollo G, Malliani A (2007) An integrated approach based on uniform quantization for the evaluation of complexity of short-term heart period variability: application to 24 h Holter recordings in healthy and heart failure humans. Chaos 17:015117CrossRefPubMedGoogle Scholar
  16. Schwerdtfeger A, Rosenkaimer AK (2011) Depressive symptoms and attenuated physiological reactivity to laboratory stressors. Biol Psychol 87:430–438CrossRefPubMedGoogle Scholar
  17. Simpson JR Jr, Snyder AZ, Gusnard DA, Raichle ME (2001) Emotion-induced changes in human medial prefrontal cortex: I. During cognitive task performance. Proc Natl Acad Sci U S A 98:683–687Google Scholar
  18. Tarvainen MP, Ranta-Aho PO, Karjalainen PA (2002) An advanced detrending method with application to HRV analysis. IEEE Trans Biomed Eng 49:172–175CrossRefPubMedGoogle Scholar
  19. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology (1996) Heart rate variability: standards of measurement, physiological interpretation and clinical use. Circulation 93:1043–1065CrossRefGoogle Scholar
  20. Thayer JF, Lane RD (2000) A model of neurovisceral integration in emotion regulation and dysregulation. J Affect Disord 61:201–216CrossRefPubMedGoogle Scholar
  21. Thayer JF, Ahs F, Fredrikson M, Sollers JJ 3rd, Wager TD (2012) A meta-analysis of heart rate variability and neuroimaging studies: implications for heart rate variability as a marker of stress and health. Neurosci Biobehav Rev 36:747–756CrossRefPubMedGoogle Scholar
  22. Tonhajzerova I, Ondrejka I, Javorka K, Turianikova Z, Farsky I, Javorka M (2010) Cardiac autonomic regulation is impaired in girls with major depression. Prog Neuropsychopharmacol Biol Psychiatry 34:613–618CrossRefPubMedGoogle Scholar
  23. Visnovcova Z, Mestanik M, Javorka M, Mokra D, Gala M, Jurko A, Calkovska A, Tonhajzerova I (2014) Complexity and time asymmetry of heart rate variability are altered in acute mental stress. Physiol Meas 35:1319–1334CrossRefPubMedGoogle Scholar
  24. Voss A, Schulz S, Schroeder R, Baumert M, Caminal P (2009) Methods derived from nonlinear dynamics for analysing heart rate variability. Philos Transact A Math Phys Eng Sci 367:277–296CrossRefGoogle Scholar
  25. Voss A, Heitmann A, Schroeder R, Peters A, Perz S (2012) Short-term heart rate variability-age dependence in healthy subjects. Physiol Meas 33:1289–1311CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • I. Tonhajzerova
    • 1
  • Z. Visnovcova
    • 2
  • A. Mestanikova
    • 1
  • A. Jurko
    • 3
  • M. Mestanik
    • 1
    Email author
  1. 1.Jessenius Faculty of Medicine in Martin (JFM CU), Department of Physiology JFM CU and Biomedical Center Martin JFM CUComenius University in BratislavaMartinSlovakia
  2. 2.Jessenius Faculty of Medicine in Martin (JFM CU), Biomedical Center Martin JFM CUComenius University in BratislavaMartinSlovakia
  3. 3.Pediatric CardiologyMartinSlovakia

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