Abstract
Chronic cough is a common medical problem. The aim of the study was to analyze chronic cough causes in non-smoking patients and to search for demographic factors associated with different cough reasons. The etiology of cough was determined by medical history, diagnostic tests and response to specific treatment. Patients with significant abnormalities in the chest radiograph or spirometry were not included. The study included 131 non-smoking patients; median age 54 years, 77 % female. The most frequent causes of cough were gastroesophageal reflux disease (GERD) (62 %) and upper airway cough syndrome (UACS) (46 %). Cough variant asthma and non-asthmatic eosinophilic bronchitis (NAEB) were diagnosed in 32 (25 %) and 19 (15 %) patients, respectively. Other cough causes were found in 27 patients (21 %). Asthma was a significantly more common cause of chronic cough in women than in men (31 % vs. 3 %, p = 0.005). A reverse relationship was demonstrated for UACS (39 % vs. 67 %, p = 0.01). Patients with chronic cough aged >50 yrs were more likely to be diagnosed with less common cough causes. In conclusion, the most common chronic cough reasons are GERD and UACS. Asthma-related cough is diagnosed more frequently in females, while UACS-related cough is more frequent in males.
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References
Ang D, Ang TL, Teo EK, Hsu PP, Tee A, Poh CH, Tan J, Ong J, Fock KM (2011) Is impedance pH monitoring superior to the conventional 24-pH monitoring in the evaluation of patients with laryngo-respiratory symptoms suspected to be due to gastroesophageal reflux disease? J Dig Dis 12:341–348
Berry MA, Hargadon B, McKenna S, Shaw D, Green RH, Brightling CE, Wardlaw AJ, Pavord ID (2005) Observational study of the natural history of eosinophilic bronchitis. Clin Exp Allergy 35:598–601
Birring SS (2011) Controversies in the evaluation and management of chronic cough. Am J Respir Crit Care Med 183:708–715
Birring SS, Brightling CE, Symon FA, Barlow SG, Wardlaw AJ, Pavord ID (2003) Idiopathic chronic cough: association with organ specific autoimmune disease and bronchoalveolar lymphocytosis. Thorax 58:1066–1070
Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A et al (2008) Allergic rhinitis and its impact on asthma (ARIA) 2008 update. Allergy 63(Suppl 86):8–160
Brightling CE (2006) Chronic cough due to nonasthmatic eosinophilic bronchitis. ACCP evidence-based clinical practice guidelines. Chest 129:116S–121S
Dettmar PW, Strugala V, Fathi H, Dettmar HJ, Wright C, Morice AH (2009) The online Cough Clinic: developing guideline-based diagnosis and advice. Eur Respir J 34:819–824
Dicipingaitis PV (2012) Thoughts on one thousand chronic cough patients. Lung 190:593–596
Dicpinigaitis PV (2006) Chronic cough due to asthma. ACCP evidence-based clinical practice guidelines. Chest 129:75S–79S
Fokkens WJ, Lund VJ, Mullol JE, Bachert C, Alobid I, Baroody F et al (2012) European position paper on rhinosinusitis and nasal polyps. Rhinology 23:1–298
GINA (2014) Global initiative for asthma. Global strategy for asthma management and prevention (revision 2014). Available from http://www.ginasthma.org. Accessed on 10 Oct 2014
Grabczak EM, Dąbrowska M, Krenke R, Domeracka-Kolodziej A, Domagala-Kulawik J, Arcimowicz M, Hamera M, Chazan R (2008) Does the established cause of chronic cough depend on diagnostic approach? J Physiol Pharmacol 59(Suppl 6):285–296
Haque RA, Usmain OS, Barnes PJ (2005) Chronic idiopathic cough. A discrete clinical entity? Chest 127:1710–1713
Hastan D, Fokkens WJ, Bachert C, Newson RB, Bislimovska J, Bockelbrink A et al (2011) Chronic rhinosinusitis in Europe – an underestimated disease. A GA2LEN study. Allergy 66:1216–1223
Irwin RS (2006) Chronic cough due to gastroesophageal reflux disease: ACCP evidence based clinical practice guidelines. Chest 129:82S–94S
Irwin RS, Madison JM (2000) Anatomical diagnostic protocol in evaluating chronic cough with specific reference to gastroesophageal reflux disease. Am J Med 108:126S–130S
Irwin RS, Baumann MH, Bolser DC, Boulet LP, Braman SS, Brightling CE et al (2006) Diagnosis and management of cough. ACCP evidenced-based clinical practice guidelines. Chest 129(Suppl 1):1s–23s
Kastelik JA, Aziz I, Ojoo JC, Thompson RH, Redington AE, Morice AH (2005) Investigation and management of chronic cough using a probability-based algorithm. Eur Respir J 25:235–243
Lee KK, Birring SS (2010) Cough and sleep. Lung 188(Suppl 1):S91–S94
Levine BM (2008) Systemic evaluation and treatment of chronic cough in a community setting. Allergy Asthma Proc 29:336–342
Lougheed MD, Turcotte SE, Fisher T (2012) Cough variant asthma: lessons learned from deep inspirations. Lung 190:17–22
McGarvey LP, Heaney LG, Lawson JT, Johnston BT, Scally CM, Ennis M, Shepherd DR, MacMahon J (1998) Evaluation and outcome of patients with chronic non-productive cough using a comprehensive diagnostic protocol. Thorax 53:738–743
McGarvey LPA (2008) Is idiopathic cough exists? Lung 186(suppl):78–81
Morice AH, Fontana GA, Sovijari ARA, Pistolesi M, Chung KF, Widdicombe J, O’Connell F, Geppetti P, Gronke L, De Jongste J, Belvisi M, Dicpinigaitis P, Fischer A, McGarvey L, Fokkens WJ, Kastelik J, ERS Task Force (2004) The diagnosis and management of chronic cough. Eur Respir J 24:481–492
Morice AH, McGarvey L, Pavord I, on behalf of the British Thoracic Society Cough Guideline Group (2006) Recommendations for the management of cough in adults. Thorax 61(Suppl 1):i1–i24
Palombini BC, Villanova CA, Araujo E, Gastal OL, Alt DC, Stolz DP, Palombini CO (1999) A pathogenic triad in chronic cough: asthma, postnasal drip syndrome, and gastroesophageal reflux disease. Chest 116:279–284
Pratter MR (2006) Chronic upper airway cough syndrome secondary to rhinosinus diseases. ACCP evidence-based clinical practice guidelines. Chest 129:63S–71S
Tutuian R (2008) Reflux monitoring: current status. Curr Gastroenterol Rep 10:263–270
Watalet JB, Van Ziele T, Brusselle G (2010) Chronic cough in upper airway diseases. Respir Med 104:652–657
Acknowledgments
E.M. Grabczak has been in part supported by grant N N402 361636 from the Polish Ministry of Science and Higher Education.
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The authors declare no conflicts of interest in relation to this article.
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Dąbrowska, M. et al. (2015). Causes of Chronic Cough in Non-smoking Patients. In: Pokorski, M. (eds) Ventilatory Disorders. Advances in Experimental Medicine and Biology(), vol 873. Springer, Cham. https://doi.org/10.1007/5584_2015_153
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DOI: https://doi.org/10.1007/5584_2015_153
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