Abstract
Anosmia is a model to study the interaction among chemoreception systems. In the head injury, the traumatic irreversible anosmia caused by damage to olfactory nerve fibers and brain regions is of enviable research interest. In this study, psychophysiological tests for a comprehensive assessment of olfactory function were utilized to investigate anosmia, together with a new technique based on the breath real-time monitoring of volatile organic compounds (VOCs). We applied the breath and VOCs analysis to investigate chemoresponsiveness in the long-term irreversible post-traumatic anosmia.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Cain WS (1982) Sumner’s ‘On testing the sense of smell’ revisited. Yale J Biol Med 55:515–519
Cain WS, Gent JP, Goodspeed RD, Leonard G (1988) Evaluation of olfactory dysfunction in the Connecticut Chemosensory Clinical Research Center. Laryngoscope 98:83–88
Costanzo RM, Becker DP (1986) Smell and taste disorders in head injury and neurosurgery patients. In: Meiselman HL, Rivlin RS (eds) Clinical measurements of taste and smell. MacMillan Publishing Company, New York, pp 565–578
Costanzo RM, Zasler ND (1991) Head trauma. In: Getchell TV, Doty RL, Bartoshuk LM, Snow JB Jr (eds) Smell and taste in health and disease. Raven, New York, pp 711–730
Doty RL, Shaman P, Dunn M (1984) Development of the University of Pennsylvania Smell Identification Test: a standardized microencapsulated test of olfactory function. Physiol Behav 32:489–502
Doty RL, Yousem DM, Pham LT, Kreshak AA, Geckle R, Lee WW (1997) Olfactory dysfunction in patients with head trauma. Arch Neurol 54:1131–1145
Hummel T, Sekinger B, Wolf SR, Pauli E, Kobal G (1997) Sniffin’ sticks: olfactory performance assessed by the combined testing of odor identification, odor discrimination and odor threshold. Chem Senses 22:39–52
Mazzatenta A, Di Giulio C, Pokorski M (2013a) Pathologies currently identified by exhaled biomarkers. Respir Physiol Neurobiol 187:128–134
Mazzatenta A, Pokorski M, Cozzutto S, Barbieri P, Veratti V, Di Giulio C (2013b) Non-invasive assessment of exhaled breath pattern in patients with multiple chemical sensibility disorder. Adv Exp Med Biol 756:179–188
Mazzatenta A, Pokorski M, Di Giulio C (2013c) Real time breath analysis in type 2 diabetes mellitus patients during cognitive task. Adv Exp Med Biol 788:247–253
Mueller CA, Hummel T (2009) Recovery of olfactory function after nine years of post-traumatic anosmia: a case report. J Med Case Rep 1–3:9283
Reden J, Mueller A, Mueller C, Konstantinidis I, Frasnelli J, Landis BN, Hummel T (2006) Recovery of olfactory function following closed head injury or infections of the upper respiratory tract. Arch Otolaryngol Head Neck Surg 132:265–269
Sumner D (1975) Disturbance of the senses of smell and taste after head injuries. In: Vinken PH, Bruyn GW (eds) Handbook of clinical neurology. North-Holland Publishing Company, Amsterdam, pp 1–25
Sumner D (1964) Post-traumatic anosmia. Brain 87:107–129
Temmel AF, Quint C, Schickinger-Fischer B, Klimek L, Stoller E, Hummel T (2002) Characteristics of olfactory disorders in relation to major causes of olfactory loss. Arch Otolaryngol Head Neck Surg 128:635–641
Zusho H (1982) Posttraumatic anosmia. Arch Otolaryngol 108:90–92
Conflicts of Interest
The authors declare no conflicts of interest in relation to this article.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Mazzatenta, A., Pokorski, M., Montinaro, D., Di Giulio, C. (2014). Chemoresponsiveness and Breath Physiology in Anosmia. In: Pokorski, M. (eds) Neurotransmitter Interactions and Cognitive Function. Advances in Experimental Medicine and Biology(), vol 837. Springer, Cham. https://doi.org/10.1007/5584_2014_66
Download citation
DOI: https://doi.org/10.1007/5584_2014_66
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-10005-0
Online ISBN: 978-3-319-10006-7
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)