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Autonomous Lab-on-a-Chip Technologies

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Autonomous Sensor Networks

Part of the book series: Springer Series on Chemical Sensors and Biosensors ((SSSENSORS,volume 13))

Abstract

Autonomous lab-on-a-chip (auto-LOC) devices are self-sustaining devices that can perform assays and report results without external cues. In this chapter, we describe the main frameworks for developing auto-LOC devices including the plug-in framework and the monolithic framework. The plug-in model aims at miniaturizing stand-alone plug-and-play components, which can then be assembled together with the microfabricated chip to develop an integrated auto-LOC device. The monolithic framework, on the other hand, seeks to integrate all components on a microfabricated microfluidic chip platform. We also highlight technologies that are relevant to portable, low-energy, and autonomous functioning of LOC devices. Finally, we present some case studies of integrated auto-LOC devices with applications ranging from point-of-care diagnostics to space exploration.

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Abbreviations

μCE:

Microchip capillary electrophoresis

AAS:

Atomic absorption spectroscopy

COC:

Cyclic olefin copolymer

ECD:

Electrochemical detection

EDL:

Electrical double layer

EO:

Electroosmotic

ICP:

Inductively coupled plasma

LFA:

Lateral flow assay

LIF:

Laser-induced fluorescence

LOC:

Lab on a chip

MS:

Mass spectrometry

PAH:

Polycyclic aromatic hydrocarbons

PZT:

Piezoelectric

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Author information

Authors and Affiliations

  1. Microfluidics Department, Caliper Life Sciences, 2061 Challenger Drive, Alameda, CA, 94501, USA

    Rajiv Bharadwaj

  2. Biotechnology and Bioengineering Department, Sandia National Laboratories, Livermore, CA, USA

    Anup K. Singh

Authors
  1. Rajiv Bharadwaj
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  2. Anup K. Singh
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Corresponding author

Correspondence to Anup K. Singh .

Editor information

Editors and Affiliations

  1. , Department of Physics, Chemistry and Bio, IFM - Linköping University, Office M314, Linköping, 58183, Sweden

    Daniel Filippini

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© 2012 Springer-Verlag Berlin Heidelberg

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Bharadwaj, R., Singh, A.K. (2012). Autonomous Lab-on-a-Chip Technologies. In: Filippini, D. (eds) Autonomous Sensor Networks. Springer Series on Chemical Sensors and Biosensors, vol 13. Springer, Berlin, Heidelberg. https://doi.org/10.1007/5346_2012_31

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