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Death Receptors and Cognate Ligands in Cancer pp 49–61Cite as

FasL Expression and Reverse Signalling

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Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 49))

Abstract

FasL plays a central role in the induction of apoptosis within the immune system. It mediates activation-induced cell death (AICD) of T lymphocytes and contributes to the cytotoxic effector function of T and NK cells. Moreover, FasL is discussed as direct effector molecule for the establishment of immune privilege and tumour survival. Besides its death-promoting activity, FasL has been implicated in reverse-signalling and might thus also play a role in T cell development and selection and the modulation of T cell activation. Considering these diverse functions, the overall FasL expression has to be tightly controlled to avoid unwanted damage. Based on an activation-associated transcriptional control, several post-transcriptional processes ensure a safe storage, a rapid mobilisation, a target-directed activity and a subsequent inactivation. Over the past years, the identification and characterisation of FasL-interacting proteins provided novel insight into the mechanisms of FasL transport, processing and reverse signalling, which might be exemplary also for the other members of the TNF family.

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Authors and Affiliations

  1. Institute of Immunology, University Hospital Schleswig-Holstein Campus Kiel, Michaelisstr. 5, D-24105, Kiel, Germany

    O. Janssen

Authors
  1. M. Lettau
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  2. M. Paulsen
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  3. D. Kabelitz
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  4. O. Janssen
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Correspondence to O. Janssen .

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Editors and Affiliations

  1. Klinik für Allgemeine Chirurgie und, Universitätsklinikum Schleswig-Holstein, Arnold-Heller-Str. 7, Kiel, 24105, Germany

    Holger Kalthoff

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Lettau, M., Paulsen, M., Kabelitz, D., Janssen, O. (2009). FasL Expression and Reverse Signalling. In: Kalthoff, H. (eds) Death Receptors and Cognate Ligands in Cancer. Results and Problems in Cell Differentiation, vol 49. Springer, Berlin, Heidelberg. https://doi.org/10.1007/400_2008_21

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