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Orphan G Protein-Coupled Receptors and Novel Neuropeptides pp 201–212Cite as

Neuromedin S: Discovery and Functions

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Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 46))

Abstract

Neuromedin S, a novel neuropeptide of 36 amino acids, was isolated from rat brain as an endogenous ligand for the orphan G protein-coupled receptors FM-3/GPR66 and FM-4/TGR-1, identified to date as type-1 and type-2 neuromedin U (NMU) receptors, respectively. The peptide was designated neuromedin S (NMS) because it is specifically expressed in the suprachiasmatic nucleus of the hypothalamus. NMS is structurally related to NMU; these peptides share a C-terminal core structure. In this review, we will outline the recent discoveries regarding the structure, cognate receptors, distribution, and possible physiological functions of NMS.

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Authors and Affiliations

  1. Department of Biochemistry, National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan

    Kenji Mori, Mikiya Miyazato & Kenji Kangawa

Authors
  1. Kenji Mori
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  2. Mikiya Miyazato
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  3. Kenji Kangawa
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Corresponding author

Correspondence to Kenji Kangawa .

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Olivier Civelli Qun-Yong Zhou

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© 2008 Springer-Verlag Berlin Heidelberg

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Mori, K., Miyazato, M., Kangawa, K. (2008). Neuromedin S: Discovery and Functions. In: Civelli, O., Zhou, QY. (eds) Orphan G Protein-Coupled Receptors and Novel Neuropeptides. Results and Problems in Cell Differentiation, vol 46. Springer, Berlin, Heidelberg. https://doi.org/10.1007/400_2007_054

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