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Cell Cycle Regulation pp 343–367Cite as

Cell Cycle Regulation in Mammalian Germ Cells

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Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 42))

Abstract

Meiosis is a unique form of cellular division by which a diploid cell produces genetically distinct haploid gametes. Initiation and regulation of mammalian meiosis differs between the sexes. In females, meiosis is initiated during embryo development and arrested shortly after birth during prophase I. In males, spermatogonial stem cells initiate meiosis at puberty and proceed through gametogenesis with no cell cycle arrest. Mouse genes required for early meiotic cell cycle events are being identified by comparative analysis with other eukaryotic systems, by virtue of gene knockout technology and by mouse mutagenesis screens for reproductive defects. This review focuses on mouse reproductive biology and describes the available mouse mutants with defects in the early meiotic cell cycle and prophase I regulatory events. These research tools will permit rapid advances in such medically relevant research areas as infertility, embryo lethality and developmental abnormalities.

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Acknowledgments

We gratefully acknowledge support from the March of Dimes Birth Defects Foundation, a Helen and Harold McMaster Endowment, and the American Cancer Society.

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  1. Department of Physiology and Cardiovascular Genomics, Medical University of Ohio, 43614, Toledo, Ohio, USA

    Changanamkandath Rajesh & Douglas L. Pittman

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  1. Changanamkandath Rajesh
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  2. Douglas L. Pittman
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Correspondence to Douglas L. Pittman .

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Philipp Kaldis

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Rajesh, C., Pittman, D.L. Cell Cycle Regulation in Mammalian Germ Cells. In: Kaldis, P. (eds) Cell Cycle Regulation. Results and Problems in Cell Differentiation, vol 42. Springer, Berlin, Heidelberg. https://doi.org/10.1007/400_003

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