Summary
Many studies about the effect of stressors on immune activities were reported, but the mechanisms of those effects were obscure yet. Restraint water immersion stress reduced splenic NK cell activity (NK activity) measured by cytotoxicity to YAC-1 cells in rats through both humoral and neural mechanisms. Electrical lesion of hypothalamic paraventricular nucleus (PVN) markedly enhanced NK activity, but the lesion of ventromedial hypothalamic nucleus (VMH) depressed NK activity. These results suggest that the stress may inhibit NK activity through the activation of hypothalamic paraventricular nucleus.
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© 2006 Springer-Verlag Tokyo
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Sato, T., Guo, S., Hisamitsu, T. (2006). Central Nervous System Concerned with the Stress Induced Inhibition of Cellular Immune Activity. In: Homma, I., Shioda, S. (eds) Breathing, Feeding, and Neuroprotection. Springer, Tokyo. https://doi.org/10.1007/4-431-28775-2_15
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DOI: https://doi.org/10.1007/4-431-28775-2_15
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-28774-2
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