Summary
Pluripotent embryonic stem (ES) cells are potent materials for both regenerative therapeutic approaches and developmental research. Recently, a novel ES cell differentiation system combined with 2-dimensional culture and flowcytometry assisted cell sorting (FACS) has been developed. In this system, cells in the cardiovascular system, that is, endothelial, mural, blood cells and cardiomyocytes can be systematically induced from common progenitor Flk1 (vascular endothelial growth factor receptor-2)-expressing cells. This system can constructively reproduce various stages of cardiovascular development in vitro, such as cell differentiation, diversification, and higher structure formation, providing novel possibilities to elucidate the cellular and molecular mechanisms of cardiovascular development. Cardiovascular cell induction from primate ES cells reveals primate-specific developmental mechanisms. ES cells will also contribute to regenerative medicine not only as a cellular source for transplantation but also for discovery of novel genes and drugs for regeneration. In this review, the significance of ES cell study in basic science and clinical medicine of cardiovascular field is discussed.
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© 2005 Springer-Verlag Tokyo
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Yamashita, J. (2005). Cardiovascular Cell Differentiation from ES Cells. In: Mori, H., Matsuda, H. (eds) Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches. Springer, Tokyo. https://doi.org/10.1007/4-431-27378-6_6
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DOI: https://doi.org/10.1007/4-431-27378-6_6
Publisher Name: Springer, Tokyo
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