Abstract
Cryptochromes were first discovered in Arabidopsis where a mutation conferring a deficiency in blue light signaling was shown to reside in a gene encoding a protein with similarities to photolyases ([Ahmad and Cashmore 1993]).The latter are flavoproteins that mediate the repair of pyrimidine dimers, generated as a result of exposure of DNA to UV-B light ([Sancar 2003]). This DNA repair activity of photolyases is dependent on irradiation with blue or UV-A light and results from transfer of an electron from the photolyase-bound flavin to the damaged pyrimidine dimer, which then undergoes isomerization to yield the monomer; the electron is returned to the photolyase. In these respects photolyases are photoreceptors mediating blue light-dependent redox reactions, and in view of the similarities between the Arabidopsis cry1 gene and photolyases it was proposed that CRY1 was also a blue light photoreceptor. Cryptochromes lack the DNA repair activity of photolyases and, at least in plants, cryptochromes are characterized by a distinguishing C-terminal extension ([Cashmore 2003]). Cryptochromes have now been characterized for several additional plant species including tomato ([Ninu et al 1999],[Weller et al 2001]) and rice ([Matsumoto et al 2003]). In both cases, as in Arabidopsis, these cryptochromes apparently play a role in blue light-mediated de-etiolation and photomorphogenesis.
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References
Ahmad M, Cashmore AR (1993) HY4 gene of A. thaliana encodes a protein with characteristics of a blue-light photoreceptor. Nature 366: 162–166
Ahmad M, Jarillo JA, Smirnova O, Cashmore AR (1998) The CRY1 blue light photoreceptor of Arabidopsis interacts with phytochrome A in vitro. Mol Cell 1: 939–948
Ahmad M, Grancher N, Heil M, Black RC, Giovani B, Galland P, Lardemer D (2002) Action spectrum for cryptochrome-dependent hypocotyl growth inhibition in Arabidopsis. Plant Physiol 129: 774–785
Bouly JP, Giovani B, Djamei A, Mueller M, Zeugner A, Dudkin EA, Batschauer A, Ahmad M (2003) Novel ATP-binding and autophosphorylation activity associated with Arabidopsis and human cryptochrome-1. Eur J Biochem 270: 2921–2928
Brudler R, Hitomi K, Daiyasu H, Toh H, Getzoff ED (2003) Identification of a new cryptochrome class. Structure, function, and evolution. Mol Cell 11: 59–67
Cashmore AR (2003) Cryptochromes: enabling plants and animals to determine circadian time. Cell 114: 537–543
Cashmore AR, Jarillo JA, Wu YJ, Liu D (1999) Cryptochromes: Blue light receptors for plants and animals. Science 284: 760–765
Deininger W, Kroger P, Hegemann U, Lottspeich F, Hegemann P (1995) Chlamyrhodopsin represents a new type of sensory photoreceptor. EMBO J 14: 5849–5858
Emery P, So WV, Kaneko M, Hall JC, Rosbash M (1998) CRY, a Drosophila clock and light-regulated cryptochrome, is a major contributor to circadian rhythm resetting and photosensitivity. Cell 95: 669–679
Folta KM, Spalding EP (2001) Unexpected roles for cryptochrome 2 and phototropin revealed by high-resolution analysis of blue light-mediated hypocotyl growth inhibition. Plant J 26: 471–478
Giovani B, Byrdin M, Ahmad M, Brettel K (2003) Light-induced electron transfer in a cryptochrome blue-light photoreceptor. Nat Struct Biol 10: 489–490
Hattar S, Lucas RJ, Mrosovsky N, Thompson S, Douglas RH, Hankins MW, Lem J, Biel M, Hofmann F, Foster RG, Yau KW (2003) Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice. Nature 424: 75–81
Helfrich-Forster C, Winter C, Hofbauer A, Hall JC, Stanewsky R (2001) The circadian clock of fruit flies is blind after elimination of all known photoreceptors. Neuron 30: 249–261
Imaizumi T, Kadota A, Hasebe M, Wada M (2002) Cryptochrome light signals control development to suppress auxin sensitivity in the moss Physcomitrella patens. Plant Cell 14: 373–386
Kanegae T, Wada M (1998) Isolation and characterization of homologues of plant blue-light photoreceptor (cryptochrome) genes from the fern Adiantum capillus-veneris. Mol Gen Genet 259: 345–353
Kleine T, Lockhart P, Batschauer A (2003) An Arabidopsis protein closely related to Synechocystis cryptochrome is targeted to organelles. Plant J 35: 93–103
Li YF, Heelis PF, Sancar A (1991) Active site of DNA photolyase: Tryptophan-306 is the intrinsic hydrogen atom donor essential for flavin radical photoreduction and DNA repair in vitro. Biochemistry 30: 6322–6329
Lin C, Robertson DE, Ahmad M, Raibekas AA, Schuman Jorns M, Dutton PL, Cashmore AR (1995) Association of flavin adenine dinucleotide with the Arabidopsis blue light receptor CRY1. Science 269: 968–970
Malhotra K, Sang-Tae K, Batschauer A, Dawut L, Sancar A (1995) Putative blue-light photoreceptors from Arabidopsis thaliana and Sinapis alba with a high degree of sequence homology to DNA photolyase contain the two photolyase cofactors but lack DNA repair activity. Biochemistry 34: 6892–6899
Matsumoto N, Hirano T, Iwasaki T, Yamamoto N (2003) Functional analysis and intracellular localization of rice cryptochromes. Plant Physiol 133: 1494–1503
Miyamoto Y, Sancar A (1998) Vitamin B2-based blue-light photoreceptors in the retino-hypothalamic tract as the photoactive pigments fr setting the circadian clocks in mammals. Proc Natl Acad Sci USA 95: 6097–6102
Neff MM, Chory J (1998) Genetic interaction between phytochrome A, phytochrome B, and cryptochrome 1 during Arabidopsis development. Plant Physiol 118: 27–35
Ninu L, Ahmad M, Miarelli C, Cashmore AR, Giuliano G (1999) Cryptochrome 1 controls tomato development in response to blue light. Plant J 18: 551–556
Panda S, Provencio I, Tu DC, Pires SS, Rollag MD, Castrucci AM, Pletcher MT, Sato TK, Wiltshire T, Andahazy M, Kay SA, Van Gelder RN, Hogenesch JB (2003) Melanopsin is required for non-image-forming photic responses in blind mice. Science 301: 525–527
Parks BM, Cho MH, Spalding EP (1998) Two genetically separable phases of growth inhibition induced by blue light in Arabidopsis seedlings. Plant Physiol 118: 609–615
Poppe C, Sweere U, Drumm-Herrel H, Schäfer E (1998) The blue light receptor cryptochrome 1 can act independently of phytochrome A and B in Arabidopsis thaliana. Plant J 16: 465–471
Reppert SM, Weaver DR (2002) Coordination of circadian timing in mammals. Nature 418: 935–941
Sancar A (2003) Structure and function of DNA photolyase and cryptochrome blue-light photoreceptors. Chem Rev 103: 2203–2237
Shalitin D, Yang H, Mockler TC, Maymon M, Guo H, Whitelam GC, Lin C (2002) Regulation of Arabidopsis cryptochrome 2 by blue-light-dependent phosphorylation. Nature 417: 763–767
Shalitin D, Yu X, Maymon M, Mockler T, Lin C (2003) Blue light-dependent in vivo and in vitro phosphorylation of Arabidopsis cryptochrome 1. Plant Cell 15: 2421–2429
Small GD, Min B, Lefebvre PA (1995) Characterization of a Chlamydomonas reinhardtii gene encoding a protein of the DNA photolyase/blue light photoreceptor family. Plant Mol Biol 28: 443–454
Stanewsky R, Kaneko M, Emery P, Beretta B, Wager-Smith K, Kay SA, Rosbash M, Hall JC (1998) The cry b mutation identifies cryptochrome as a circadian photoreceptor in Drosophila. Cell 95: 681–692
Todo T (1999) Functional diversity of the DNA photolyase/blue light receptor family. Mutat Res 434: 89–97
van der Horst GT, Muijtjens M, Kobayashi K, Takano R, Kanno S, Takao M, de Wit J, Verkerk A, Eker AP, van Leenen D, Buijs R, Bootsma D, Hoeijmakers JH, Yasui A (1999) Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms. Nature 398: 627–630
Van Gelder RN (2002) Tales from the crypt(ochromes). J Biol Rhythms 17: 110–120
Wang X, Iino M (1998) Interaction of cryptochrome 1, phytochrome, and ion fluxes in blue-light-induced shrinking of Arabidopsis hypocotyl protoplasts. Plant Physiol 117: 1265–1279
Wang H, Ma LG, Li J, Zhao HY, Deng XW (2001) Direct interaction of Arabidopsis cryptochromes with COP1 in light control development. Science 294: 154–158
Weissig H, Beck CF (1991) Action spectrum for the light-dependent step in gametic differentiation of Chlamydomonas reinhardtii. Plant Physiol 97: 118–121
Weller JL, Perrotta G, Schreuder ME, van Tuinen A, Koornneef M, Giuliano G, Kendrick RE (2001) Genetic dissection of blue-light sensing in tomato using mutants deficient in cryptochrome 1 and phytochromes A, B1 and B2. Plant J 25: 427–440
Yang HQ, Tang RH, Cashmore AR (2001) The signaling mechanism of Arabidopsis CRY1 involves direct interaction with COP1. Plant Cell 13: 2573–2587
Yang HQ, Wu YJ, Tang RH, Liu D, Liu Y, Cashmore AR (2000) The C termini of Arabidopsis cryptochromes mediate a constitutive light response. Cell 103: 815–827
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© 2005 Yamada Science Foundation and Springer-Verlag Tokyo
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Cashmore, A.R. (2005). Cryptochrome Overview. In: Wada, M., Shimazaki, Ki., Iino, M. (eds) Light Sensing in Plants. Springer, Tokyo. https://doi.org/10.1007/4-431-27092-2_13
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DOI: https://doi.org/10.1007/4-431-27092-2_13
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