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Artificial Oxygen Carrier pp 135–168Cite as

Hemoglobin-Vesicles (HbV) as Artificial Oxygen Carriers

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Part of the book series: Keio University International Symposia for Life Sciences and Medicine ((KEIO,volume 12))

Summary

Considering the physiological significance of the cellular structure of a red blood cell (RBC), it may be reasonable to mimic its structure for designing a hemoglobin (Hb)-based oxygen carrier. In this chapter, we have summarized the characteristics and performances of Hb-vesicles (HbV) that have been developed on the basis of molecular assembly. Collaborative in vitro and in vivo studies have revealed sufficient safety and efficacy of HbV.

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Authors and Affiliations

  1. Advanced Research Institute for Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo, 169-8555, Japan

    Hiromi Sakai, Keitaro Sou, Shinji Takeoka & Eishun Tsuchida

  2. Department of Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan

    Koichi Kobayashi

Authors
  1. Hiromi Sakai
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  2. Keitaro Sou
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  3. Shinji Takeoka
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  4. Koichi Kobayashi
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  5. Eishun Tsuchida
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Editors and Affiliations

  1. Division of General Thoracic Surgery, Department of Surgery School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan

    Koichi Kobayashi M.D., Ph.D. (Chief Professor of Surgery) & Hirohisa Horinouchi M.D., Ph.D. (Chief Professor of Surgery) & 

  2. Department of Polymer Chemistry, Waseda University, 3-4-1 Ohkubo, Shinjuku-ku, Tokyo, 169-8555, Japan

    Eishun Tsuchida Ph.D. (Professor Emeritus) (Professor Emeritus)

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© 2005 Springer-Verlag Tokyo

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Sakai, H., Sou, K., Takeoka, S., Kobayashi, K., Tsuchida, E. (2005). Hemoglobin-Vesicles (HbV) as Artificial Oxygen Carriers. In: Kobayashi, K., Tsuchida, E., Horinouchi, H. (eds) Artificial Oxygen Carrier. Keio University International Symposia for Life Sciences and Medicine, vol 12. Springer, Tokyo. https://doi.org/10.1007/4-431-26651-8_10

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  • DOI: https://doi.org/10.1007/4-431-26651-8_10

  • Publisher Name: Springer, Tokyo

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