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Biopolymers II pp 245–274Cite as

Biodegradable polymer scaffolds to regenerate organs

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Part of the book series: Advances in Polymer Science ((POLYMER,volume 122))

Abstract

The problem of donor scarcity precludes the widespread utilization of whole organ transplantation as a therapy to treat many diseases for which there is often no alternative treatment. Cell transplantation using biodegradable polymer scaffolds offers the possibility to create completely natural new tissue and replace organ function. Tissue inducing biodegradable polymers can also be utilized to regenerate certain tissues and without the need for in vitro cell culture. Biocompatible, biodegradable polymers play an important role in organ regeneration as temporary substrates to transplanted cells which allow cell attachment, growth, and retention of differentiated function. Novel processing techniques have been developed to manufacture reproducibly scaffolds with high porosities for cell seeding and large surface areas for cell attachment. These scaffolds have been used to demonstrate the feasibility of regenerating several organs.

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Author information

Authors and Affiliations

  1. Cox Laboratory for Biomedical Engineering, Department of Chemical Engineering and Institute of Biosciences and Bioengineering, Rice University, P.O. Box 1892, 77251-1892, Houston, TX, USA

    R. C. Thomson, M. C. Wake & A. G. Mikos

  2. Department of Orthopaedic Surgery, Wilford Hall Medical Center, 78236, Lackland AFB, TX, USA

    M. J. Yaszemski

Authors
  1. R. C. Thomson
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  2. M. C. Wake
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  3. M. J. Yaszemski
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  4. A. G. Mikos
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Editor information

Nicholas A. Peppas Robert S. Langer

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© 1995 Springer-Verlag

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Thomson, R.C., Wake, M.C., Yaszemski, M.J., Mikos, A.G. (1995). Biodegradable polymer scaffolds to regenerate organs. In: Peppas, N.A., Langer, R.S. (eds) Biopolymers II. Advances in Polymer Science, vol 122. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3540587888_18

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  • DOI: https://doi.org/10.1007/3540587888_18

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-58788-0

  • Online ISBN: 978-3-540-49102-6

  • eBook Packages: Springer Book Archive

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