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Catalytic Asymmetric Addition Reactions of Cu(I)-Conjugated Soft Carbon Nucleophiles

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Progress in Enantioselective Cu(I)-catalyzed Formation of Stereogenic Centers

Part of the book series: Topics in Organometallic Chemistry ((TOPORGAN,volume 58))

Abstract

Copper is a ubiquitous element on the earth. Copper catalysts promote a wide variety of reaction types by acting as a Lewis acid, a π acid, a Brønsted base, or an electron mediator. These features make copper catalysts particularly attractive in modern organic chemistry. In this review, we discuss examples of recent copper(I)-catalyzed asymmetric C–C bond-forming reactions via the addition of soft copper(I)-conjugated carbon nucleophiles to carbonyl electrophiles. Specifically, we focus on the unique orthogonal reactivity of soft copper(I)-conjugated carbon nucleophiles to hard protic functional groups, which would allow for protecting group-minimized molecular synthesis.

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Correspondence to Motomu Kanai .

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Wei, X., Shimizu, Y., Kanai, M. (2015). Catalytic Asymmetric Addition Reactions of Cu(I)-Conjugated Soft Carbon Nucleophiles. In: Harutyunyan, S. (eds) Progress in Enantioselective Cu(I)-catalyzed Formation of Stereogenic Centers. Topics in Organometallic Chemistry, vol 58. Springer, Cham. https://doi.org/10.1007/3418_2015_163

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