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Biological Organometallic Chemistry of B12

  • Philip A. Butler
  • Bernhard Kräutler
Chapter
Part of the Topics in Organometallic Chemistry book series (TOPORGAN, volume 17)

Abstract

Vitamin B12, the “antipernicious anemia factor” required for human and animal metabolism, was discovered in the late 1940s. B12-derivatives are cobalt complexes of the unique and remarkably complex corrin ligand, that belongs to the class of the natural tetrapyrroles. The B12-coenzymes are the organometallic cofactors in various important enzymatic reactions and are particularly relevant in the metabolism of some archaea and (other) anaerobic microorganisms. Indeed, the microorganisms are the only natural sources of the B12-derivatives, while (with the exception of the higher plants) most living organisms depend on these cobalt-corrinoids. Vitamin B12-derivatives thus hold an important position in the life sciences and have attracted particular interest from medicine, biology, chemistry and physics.

Cobalt Coenzyme B12 Methyl group transfer Radical reaction Vitamin B12 

Abbreviations

Ado

Adenosyl

AdoCbl

5′-Deoxy-5′-adenosylcobalamin, adenosylcobalamin, coenzyme B12

Cbl

Cobalamin (DMB-cobamide)

CNCbl

Cyanocobalamin

DCE

Dichloroethene

DD

Diol dehydratase

DMB

5,6-Dimethylbenzimidazole

EAL

Ethanolamine ammonia lyase

GD

Glycerol dehydratase

GM

Glutamate mutase

H2OCbl

Aquocobalamin, B12a

HOCbl

Hydroxocobalamin

ICM

Isobutyryl-CoA mutase

LAM

Lysine aminomutase

MeCbl

Methylcobalamin

MGM

Methyleneglutarate mutase

MMCM

Methylmalonyl-CoA mutase

NHE

Normal hydrogen electrode

NMR

Nuclear magnetic resonance

NOE

Nuclear Overhauser effect

PLP

Pyridoxal-phosphate

PCE

Tetrachloroethene

SAM

S-adenosylmethionine (= AdoMet)

SCE

Saturated calomel electrode

TCE

Trichloroethene

UV

Ultraviolet spectrum

UV-vis

Ultraviolet visible absorbance spectrum

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Authors and Affiliations

  1. 1.Institute of Organic Chemistry & Center of Molecular Biosciences (CMBI)University of InnsbruckInnsbruckAustria

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