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23.5 Literatur

  1. Albes JM, Brandes H, Heinemann MK, Scheule A, Wahlers T (1997) Potassium-Reduced Lung Preservation Solutions: A Screening Study. Eur Surg Res 29:327–338

    PubMed  CAS  Google Scholar 

  2. Albes JM, Fischer F, Bando T, Heinemann MK, Scheule T, Wahlers T (1997) Influence of the Perfusate Temperature on Lung Preservation: Is There an Optimum? Eur Surg Res 29:5–11

    PubMed  CAS  Google Scholar 

  3. Alvarez A, Algar J, Santos F, Lama R, Aranda JL, Baamonde C, Lopez-Pujol J, Salvatierra A (2001) Airway complications after lung transplantation: a review of 151 anastomoses. Eur J Cardiothorac Surg 19:381–387

    Article  PubMed  CAS  Google Scholar 

  4. Aoe M, Okabayashi K, Cooper JD, Patterson GA (1996) Hyperinflation of canine lung allografts during storage increases reperfusion pulmonary edema. J Thorac Cardiovasc Surg 112:94–102

    Article  PubMed  CAS  Google Scholar 

  5. Baldwin JC, Frist WH, Starkey TD (1987) Distant organ procurement for combined heart and lung transplantation using a pulmonary artery flush and simple topical hypothermia for graft preservation. Ann Thorac Surg 43:670–673

    Article  PubMed  CAS  Google Scholar 

  6. Bando K, Tago M, Teraoka H, Seno S, Senoo Y, Teramoto S (1989) Extended cardiopulmonary preservation for heart-lung transplantation: a comparative study of superoxide dismutase. J Heart Lung Transplant 8:59–66

    CAS  Google Scholar 

  7. Bando T, Albes JM, Fehrenbach H, Nüsse T, Schäfers HJ, Wahlers T (1998) Influence of the Potassium Concentration on Functional and Structural Preservation of the Lung: Where is the Optimum? J Heart Lung Transplant 17:715–724

    PubMed  CAS  Google Scholar 

  8. Bando T, Albes JM, Nüsse T, Wada H, Hitomi S, Wahlers T, Schäfers HJ (1998) Comparison of Euro-Collins Solution, Low-Potassium Dextran Solution Containing Glucose, and ET-Kyoto Solution for Lung Preservation in an Extracorporeal Rat Lung Perfusion Model. Eur Surg Res 30:297–304

    Article  PubMed  CAS  Google Scholar 

  9. Baretti R, Bitu-Moreno J, Beyersdorf F, Matheis G, Francischetti I, Kreitmayr B (1995) Distribution of Lung Preservation Solutions in Parenchyma and Airways: Influence of Atelectasis and Route of Delivery. J Heart Lung Transplant 14:80–91

    PubMed  CAS  Google Scholar 

  10. Baron O, Fabre S, Haloun A, Treilhaud M, al Habasch O, Duveau D, Michaud JL, Despins P (2002) Retrospective clinical comparison of Celsior solution to modified blood Wallwork solution in lung transplantation for cystic fibrosis. Prog Transplan 12:176–180

    CAS  Google Scholar 

  11. Barr ML, Nishanian GP, Sakamaki Y, Carey JN, Chang J, Starnes VA (1997) A New Organ Preservation Solution, Celsior, Is Superior to Euro-Collins and University of Wisconsin Solutions in Decreasing Lung Reperfusion Injury. Transplant Proc 29:1357–1358

    Article  PubMed  CAS  Google Scholar 

  12. Belzer FO, Southard JH (1988) Principles of solid-organ preservation by cold storage. Transplantation 45:673–676

    PubMed  CAS  Google Scholar 

  13. Bigelow WG, Lindsay WK, Greenwood WF (1950) Hypothermia. Its possible role in cardiac surgery: An investigation of actors governing survival in dogs at low body temperatures. Ann Surg 132:849–852

    PubMed  CAS  Google Scholar 

  14. Binns OAR, DeLima NF, Buchanan SA, Cope JT, King RC, Marek CA, Shockey KS, Tribble CG, Kron IL (1996) Both blood and crystalloid-based extracellular solutions are superior to intracellular solutions for lung preservation. J Thorac Cardiovasc Surg 112:1515–1521

    Article  PubMed  CAS  Google Scholar 

  15. Bonser RS, Fragomeni L, Rotenberg D, Fischel R, Jamieson S, Kaye M (1989) Dose dependent effect of allopurinol on lung function following 12 hour lung preservation. Chest 96:246S

    Google Scholar 

  16. Bonser RS, Fragomeni LS, Edwards BJ (1990) Allopurinol and desferoxamine improve canine lung preservation. Transplant Proc 22:557–558

    PubMed  CAS  Google Scholar 

  17. Brandes H, Albes JM, Conzelmann A, Kalinka A, Ziemer G (1999) Comparison of Celsior and Perfadex for Lung Preservation in an Extracorporeal Pulsatile Perfused Lung Model. Thorac Cardiovasc Surg 47:225

    Google Scholar 

  18. Brandes H, Albes JM, Haas B, Ziemer G (2001) Influence of high molecular dextrans on lung function in an ex vivo porcine lung model. J Surg Res 101:225–231

    Article  PubMed  CAS  Google Scholar 

  19. Bryan CL, Cohen DJ, Fornos PS, Owens SL, Jenkonson SG (1990) Glutathione cryopreservation preserves pulmonary gas exchange after 5 hours of ischemia on dog lung autotransplants. Am Rev Respir Dis 141:A406

    Google Scholar 

  20. Bund M, Strüber M, Heine J, Jaeger K, Wahlers T, Haverich A, Piepenbrock S (1998) Effect of Lung Allograft Ischaemia Duration on Postreperfusion Graft Function and Postoperative Course. Thorac Cardiovasc Surg 46:93–96

    PubMed  CAS  Google Scholar 

  21. Cecconi O, Nelson RM, Roberts WG, Hanasaki K, Mannori G, Schultz C, Ulich TR, Aruffo A, Bevilacqua MP (1994) Inositol Polyanions. J Biol Chem 21:1560–1566

    Google Scholar 

  22. Chastre J, Fagon J-Y, Soler P (1990) Bronchoalveolar lavage for rapid diagnosis of the fat embolism syndrome in trauma patients. Ann Intern Med 113:583–588

    PubMed  CAS  Google Scholar 

  23. Chen CZ, Gallagher RC, Ardery P, Dyckman W, Donahue S, Low HBC (1997) Retrograde Flush and Cold Storage for Twenty-two to Twenty-five Hours Lung Preservation With and Without Prostaglandin El. J Heart Lung Transplant 16:658–666

    PubMed  CAS  Google Scholar 

  24. Chen CZ, Gallaghere RC, Ardery P, Dyckman W, Low HBC (1996) Retrograde Versus Antegrade Flush in Canine Left Lung Preservation for Six Hours. J Heart Lung Transplant 15:395–403

    PubMed  CAS  Google Scholar 

  25. Chien S, Zhang F, Niu W, Tseng MT, Gray L (2000) Comparison of University of Wisconsin, Euro-Collins, Low-Potassium Dextran, and Krebs-Henseleit Solutions for hypo thermic lung preservation. J Thorac Cardiovasc Surg 119:921–930

    Article  PubMed  CAS  Google Scholar 

  26. Clark SC, Sudarshan C, Roughan J, Flecknell PA, Dark JH (1999) Modulation of reperfusion injury after single lung transplantation by pentoxifylline, inositol polyanions, and SIN-1. J Thorac Cardiovasc Surg 117:556–564

    Article  PubMed  CAS  Google Scholar 

  27. Collins GM, Bravo-Shugarman M, Terasaki PI (1969) Kidney preservation for transplantation. Lancet 2:1219–1222

    Article  PubMed  CAS  Google Scholar 

  28. Collins GM, Halasz NA (1976) Forty-eight hour ice storage of kidneys: importance of cation content. Surgery 79:432–435

    PubMed  CAS  Google Scholar 

  29. Connaughton PJ, Bahuth JJ, Lewis FJ (1962) Lung ischemia up to six hours; influence of topical cooling in situ on subsequent pulmonary function. Dis Chest 41:404–408

    PubMed  CAS  Google Scholar 

  30. Conte JV, Baumgartner WA (2000) Overview and Future Practice Patterns in Cardiac and Pulmonary Preservation. J Card Surg 15:91–107

    PubMed  CAS  Google Scholar 

  31. Conte JV, Katz NM, Foegh ML, Wallace RB, Ramwell PW (1991) Iron chelation therapy and lung transplantation: effects of desferoxamine on lung preservation in canine single lung transplantation. J Thorac Cardiovasc Surg 101:1024–1029

    PubMed  Google Scholar 

  32. Cooper JD, Pearson FG, Patterson GA (1987) Technique of successful lung transplantation in humans. J Thorac Cardiovasc Surg 93:173–181

    PubMed  CAS  Google Scholar 

  33. Cremer J, Jurmann M, Dammenhayn L, Wahlers T, Haverich A, Borst HG (1989) Oxygen free radical scavengers to prevent pulmonary reperfusion injury after heart-lung transplantation. J Heart Lung Transplant 8:330–336

    CAS  Google Scholar 

  34. Dantzker DR (1995) Respiratory Monitoring. In: Dantzker DR, McIntyer NR, Bakow ED: Comprehensive respiratory care. W.B. Saunders Company, Philadelphia, pp 245–246

    Google Scholar 

  35. Dawson CA, Jones RL, Hamilton LH (1973) Hemodynamic responses of isolated cat lungs during forward and retrograde perfusion. J Appl Physiol 35:95–102

    PubMed  CAS  Google Scholar 

  36. DeCampos KN, Keshavjee S, Liu M, Slutsky AS (1998) Optimal Inflation Volume for Hypothermic Preservation Of Rat Lungs. J Heart Lung Transplant 17:599–607

    PubMed  CAS  Google Scholar 

  37. Deffebach ME, Charan NB, Lakshminarayan S, Butler J (1987) The Bronchial Circulation. Am Rev Respir Dis 135:463–481

    PubMed  CAS  Google Scholar 

  38. DeLima NF, Binns OAR, Buchanan SA, Cope JT, Mauney MC, Shockey KS, Tribble CG, Kron IL (1996) Low-Potassium Solutions for Lung Preservation in the Setting of High-Flow Reperfusion. Ann Thorac Surg 61:973–976

    Article  PubMed  CAS  Google Scholar 

  39. DeMeo DL, Ginns LC (2001) Lung transplantation at the turn of the century. Annu Rev Med 52:185–201

    Article  PubMed  CAS  Google Scholar 

  40. dePerrot M, Fischer S, Liu M, Jin R, Bai XH, Waddell TK, Keshavjee S (2001) Prostaglandin El protects lung transplants from ischemia-reperfusion injury: a shift from pro-to anti-inflammatoty cytokines. Transplantation 72:1505–1512

    Article  CAS  Google Scholar 

  41. Divisi D, Montagna P, Jegaden O, Giusti L, Berti A, Coloni GF, Ricci C, Mikaeloff P (2001) A comparative study of Euro-Collins, low potassium University of Wisconsin and cold modified blood solutions in lung preservation in acute autotransplantations in the pig. Eur J Cardiothorac Surg 19:333–338

    Article  PubMed  CAS  Google Scholar 

  42. Egan TM, Ulicny KS, Lambert CJ, Wilcox BR (1993) Effect of a Free Radical Scavenger on Cadaver Lung Transplantation. Ann Thorac Surg 55:1453–1459

    Article  PubMed  CAS  Google Scholar 

  43. Eschwege P, Paradis V, Conti M, Holstege A, Richet F, Deteve J, Menager P, Legrand A, Jardin A, Bedossa P, Benoit G (1999) In situ detection of lipid peroxidation by-products as markers of renal ischemia injuries in rat kidneys. J Urol 162:553–557

    Article  PubMed  CAS  Google Scholar 

  44. Fantone JC, Funkel SL, Ward PA, Zurier RB (1980) Suppression by prostaglandin El of vascular permeability induced by vasoactive inflammatory mediators. J Immunol 125:2591–2596

    PubMed  CAS  Google Scholar 

  45. Fantone JC, Marasco WA, Elgas LJ, Ward PA (1984) Stimulus specifity of prostaglandin inhibition of rabbit polymorphonuclear leucocyte lysosomal enzyme release and superoxide anion production. Am J Pathol 115:9–16

    PubMed  CAS  Google Scholar 

  46. Fehrenbach A, Fehrenbach H, Wittwer T, Ochs M, Wahlers T, Richter J (2001) Evaluation of pulmonary edema: stereological versus gravimetrical analysis. Eur Surg Res 33:270–278

    Article  PubMed  CAS  Google Scholar 

  47. Fehrenbach A, Ochs M, Wahlers T, Wittwer T, Schmiedl A, Elki S, Meyer D, Richter J, Fehrenbach H (2000) Beneficial effect of lung preservation is related to ultrastructural integrity of tubular myelin after experimental ischemia and reperfusion. Am J Resp Crit Care Med 161:2058–2065

    PubMed  CAS  Google Scholar 

  48. Fehrenbach A, Ochs M, Wittwer T, Cornelius JF, Fehrenbach H, Wahlers T, Richter J (1999) Stereological estimation of the volume weighted mean volumes of alveoli and acinar pathways in the rat lung to describe alterations of the gas-exchange regions after ischemia/reperfusion. Journal of Anatomy 194:127–135

    Article  PubMed  Google Scholar 

  49. Fehrenbach A, Wittwer T, Cornelius JF, Ochs M, Fehrenbach H, Wahlers T, Richter J (1999) Improvement of rat lung structure and function after preservation with Celsior. J Surg Res 82:285–293

    Article  PubMed  CAS  Google Scholar 

  50. Fehrenbach A, Wittwer T, Fehrenbach H, Richter J, Wahlers T (2001) Pathological effects of nitric oxide on lung parenchyma after experimental ischemia and reperfusion. Thorac Cardiovasc Surg 49(Suppl 1):61

    Google Scholar 

  51. Fehrenbach A, Wittwer T, Meyer D, v. Vietinghoff S, Viehover M, Fehrenbach H, Richter J, Wahlers T (2001) Nitroglycerin Alters Alveolar Type II Cell Ultrastructure After Ischemia and Reperfusion. J Heart Lung Transplant 20:876–888

    Article  PubMed  CAS  Google Scholar 

  52. Fischer S, Hopkinson D, Liu M, MacLean AA, Edwards V, Cutz E, Keshavjee S (2001) Raffinose Improves 24-Hour Lung Preservation in Low Potassium Dextran Solution: A Histologic and Ultrastructural Analysis. Ann Thorac Surg 71:1140–1145

    Article  PubMed  CAS  Google Scholar 

  53. Fischer S, Matte-Martyn A, dePerrot M, Waddell TK, Sekine Y, Hutcheon M, Keshavjee S (2001) Low-potassium dextran preservation solution improves lung function after human lung transplantation. J Thorac Cardiovasc Surg 120:594–596

    Article  Google Scholar 

  54. Fischer S, Renz D, Schaper W, Karliczek GF (2001) In vitro effects of dexamethasone on hypoxia-induced hyperpermeability and expression of vascular endothelial growth factor. Eur J Pharmacol 411:231–243

    Article  PubMed  CAS  Google Scholar 

  55. Fiser SM, Cope JT, Kron IL, Kaza AK, Long SM, Kern JA, Tribble CG (2001) Aerosolized prostacyclin (Epoprostenol) as an alternative to inhaled nitric oxide for patients with reperfusion injury after lung transplantation. J Thorac Cardiovasc Surg 121:981–982

    Article  PubMed  CAS  Google Scholar 

  56. Fisher AJ, Donnelly SC, Hirani N, Haslett C, Strieter RM, Dark JH, Corris PA (2001) Elevated Levels of Interleukin-8 in Donor Lungs Is Associated with Early Graft Failure after Lung Transplantation. Am J Respir Crit Care Med 163:259–265

    PubMed  CAS  Google Scholar 

  57. Freeman B (1994) Free Radical Chemistry of Nitric Oxide — Looking at the Dark Side. Chest 105(Suppl):79S–84S

    PubMed  CAS  Google Scholar 

  58. Fukuse T, Albes JM, Brandes H, Takahashi Y, Demertzis S, Schäfers HJ (1996) Comparison of low potassium Euro-Collins solution and standard Euro-Collins solution in an extracorporeal rat heart-lung model. Eur J Cardiothorac Surg 10:621–627

    Article  PubMed  CAS  Google Scholar 

  59. Fukuse T, Albes JM, Wilhelm A, Bando T, Fischer F, Hausen B, Rohde R, Wahlers T, Schäfers HJ (1996) Influence of Dextrans on Lung Preservation: Is the Molecular Weight Important? J Heart Lung Transplant 15:903–910

    PubMed  CAS  Google Scholar 

  60. Fukuse T, Hirata T, Nakamura T, Ueda M, Kawashima M, Hitomi S, Wada H (1999) Role of saccharides on lung preservation. Transplantation 68:110–117

    Article  PubMed  CAS  Google Scholar 

  61. Fukuse T, Hirata T, Ueda M, Hitomi S, Wada H (1996) Effects of Euro-Collins, University of Wisconsin, and new extracellular-type rehalase-containing Kyoto solutions in an ex vivo rat lung preservation model. Transplantation 62:1212–1217

    Article  PubMed  CAS  Google Scholar 

  62. Gade J, Qvortrup K, Andersen CB, Olsen PS (2001) Bronchial Transsection and Reanastomosis in Pigs With and Without Bronchial Arterial Circulation. Ann Thorac Surg 71:332–336

    Article  PubMed  CAS  Google Scholar 

  63. Gorier A, Haverich A (2000) Adequate Lung Preservation for Clinical Lung Transplantation: An Important Condition for Satisfactory Graft Function. J Card Surg 15:141–148

    Google Scholar 

  64. Greco R, Cordovilla G, Sanz E, Benito J, Criado A, Gonzales M, De Miguel E (1998) Warm ischemic time tolerance after ventilated non-heart-beating lung donation in piglets. Eur J Cardiothorac Surg 14:319–325

    Article  PubMed  CAS  Google Scholar 

  65. Hall TS, Borkon AM, Gurtner GC (1988) Improved static lung preservation with corticosteroids and hypothermia. J Heart Lung Transplant 7:348–352

    CAS  Google Scholar 

  66. Haniuda M, Dresler CM, Hasegawa S, Patterson GA, Cooper JD (1994) Changes in Vascular Permeability With Ischemic Time, Temperature, and Inspired Oxygen Fraction in Isolated Rabbit Lungs. Ann Thorac Surg 57:708–714

    Article  PubMed  CAS  Google Scholar 

  67. Haniuda M, Hasegawa S, Shiraishi T, Dresler CM, Cooper JD, Patterson GA (1996) Effects of inflation volume during lung preservation on pulmonary capillary permeability. J Thorac Cardiovasc Surg 112:85–93

    Article  PubMed  CAS  Google Scholar 

  68. Hardesty RL, Aeba R, Armitage JM, Kormos RL, Griffith BP (1993) A clinical trial of University of Wisconsin solution for pulmonary preservation. J Thorac Cardiovasc Surg 105:660–666

    PubMed  CAS  Google Scholar 

  69. Hardesty RL, Griffith BP (1985) Procurement for combined heart-lung transplantation. Bilateral thoracotomy with sternal transection, cardiopulmonary bypass, and profound hypothermia. J Thorac Cardiovasc Surg 89:795–799

    PubMed  CAS  Google Scholar 

  70. Hausen B, Müller P, Bahra M (1996) Donor pretreatment with intravenous prostacydin versus inhaled nitric oxide in experimental lung transplantation. Transplantation 62:1714–1719

    Article  PubMed  CAS  Google Scholar 

  71. Hausen B, Ramsamooj R, Hewitt CW, Schroder F, Beuke M, Poets CF, Schäfers HJ (1996) The importance of static lung inflation during organ storage. Transplantation 62:1720–1725

    Article  PubMed  CAS  Google Scholar 

  72. Haverich A, Aziz S, Scott WC, Jamieson SW, Shumway NE (1986) Improved lung preservation using Euro-Collins solution for flush-perfusion. Thorac Cardiovasc Surg 34:368–376

    PubMed  CAS  Google Scholar 

  73. Haverich A, Scott WC, Jamieson SW (1985) Twenty years of lung preservation — a review. Heart Transplant IV:234–240

    Google Scholar 

  74. Haverich A (1999) Experience With Lung Transplantation. Ann Thorac Surg 67:305–312

    Article  PubMed  CAS  Google Scholar 

  75. Herrera JM, McNeil KD, Higgins RSD, Coulden RA, Flower CD, Nashef SAM, Wallwork J (2001) Airway Complications After Lung Transplantation: Treatment and Long-Term Outcome. Ann Thorac Surg 71:989–994

    Article  PubMed  CAS  Google Scholar 

  76. Hiramatsu Y, Muraoka R, Chiba Y, Sasaki M (1994) Influence of pH of Preservation Solution on Lung Viability. Ann Thorac Surg 58:1083–1086

    Article  PubMed  CAS  Google Scholar 

  77. Hirt SW, Wahlers T, Jurmann MJ, Dammenhayn L, Kemnitz J, Rohde R, Haverich A (1992) University of Wisconsin versus modified Euro-Collins Solution for Preservation. Ann Thorac Surg 53:74–79

    Article  PubMed  CAS  Google Scholar 

  78. Hirt SW, Wahlers T, Jurmann MJ, Fieguth HG, Dammenhayn L, Haverich A (1992) Improvement of currently used methods for lung preservation with prostacyclin and University of Wisconsin solution. J Heart Lung Transplant 11:656–664

    PubMed  CAS  Google Scholar 

  79. Hooper TL, Jones MT, Thomson DS (1990) Modulation of ischemic injury by corticosteroids. Transplantation 50:530–532

    PubMed  CAS  Google Scholar 

  80. Hooper TL, Thompson DS, Jones MT (1990) Amelioration of lung ischemic injury with prostacyclin. Transplantation 49:1031–1035

    PubMed  CAS  Google Scholar 

  81. Hopkinson DN, Bhabra MS, Hooper TL (1998) Pulmonary Graft Preservation: A Worldwide Survey of Current Clinical Practice. J Heart Lung Transplant 17:525–531

    PubMed  CAS  Google Scholar 

  82. Hopkinson DN, Odom NJ, Bridgewater BJM, Hooper TL (1996) Comparison of saccharides as osmotic impermeants during hypothermic lung graft preservation. Transplantation 61:1667–1671

    Article  PubMed  CAS  Google Scholar 

  83. Hopkinson DN, Odom NJ, Bridgewater BJM, Hooper TL (1994) University of Wisconsin Solution for Lung Graft Preservation: Which Components are Important? J Heart Lung Transplant 13:990–997

    PubMed  CAS  Google Scholar 

  84. Inci I, Dutly A, Inci D, Boehler A, Weder W (2001) Recipient Treatment With Trimetazidine Improves Graft Function and Protects Energy Status After Lung Transplantation. J Heart Lung Transplant 20:1115–1122

    Article  PubMed  CAS  Google Scholar 

  85. Ingemansson R, Massa G, Pandita RK, Sjöberg T, Steen S (1995) Perfadex is Superior to Euro-Collins Solution Regarding 24-Hour Preservation of Vascular Function. Ann Thorac Surg 60:1210–1214

    Article  PubMed  CAS  Google Scholar 

  86. Ingemansson R, Sjöberg T, Steen S (1996) Importance of Calcium in Long-Term Preservation of the Vasculature. Ann Thorac Surg 61:1158–1162

    Article  PubMed  CAS  Google Scholar 

  87. Jones G, Hurley JV (1984) The effect of prostacyclin in the adhesion of leucocytes to injured vascular endothelium. J Pathol 142:51–59

    Article  PubMed  CAS  Google Scholar 

  88. Jurmann MJ, Dammenhayn L, Schäfers HJ, Wahlers T, Fieguth HG, Haverich A (1987) Prostacyclin as an additive to single crystalloid flush: improved pulmonary preservation in heart-lung transplantation. Transplant Proc 19:4103–4104

    PubMed  CAS  Google Scholar 

  89. Kayano K, Toda K, Naka Y, Pinsky DJ (1999) Identification of Optimal Conditions for Lung Graft Storage With Euro-Collins Solution by Use of a Rat Orthotopic Lung Transplant Model. Circulation 100(Suppl II):II-257–II-261

    CAS  Google Scholar 

  90. Keenan RJ, Griffith BP, Kormos RL, Armirage JM, Hardesty RL (1991) Increased Perioperative Lung Preservation Injury with Lung Procurement by Euro-Collins Solution Flush. J Heart Lung Transplant 10:650–655

    PubMed  CAS  Google Scholar 

  91. Keshavjee SH, Yamazaki F, Yokomise H, Cardoso PF, Mullen JBM, Slutsky AS, Patterson GA (1992) The role of dextran 40 and potassium in extended hypothermic lung preservation for transplantation. J Thorac Cardiovasc Surg 103:314–325

    PubMed  CAS  Google Scholar 

  92. Khan SU, Salloum J, O’Donovan PB, Mascha EJ, Mehta AC, Matthay MA, Arroliga AC (1999) Acute pulmonary edema after lung transplantation: the pulmonary reimplantation response. Chest 116:187–194

    Article  PubMed  CAS  Google Scholar 

  93. Kimblad PA, Sjöberg T, Massa G, Solem JO, Steen S (1991) High potassium contents in organ preservation solutions causes strong pulmonary vasoconstriction. Ann Thorac Surg 52:523–528

    Article  PubMed  CAS  Google Scholar 

  94. King RC, Binns OA, Kanithanon RC, Parrino PE, Reece TB, Maliszewskyj JD, Shockey KS, Tribble CG, Kron IL (1997) Acellular Low-Potassium Dextran Preserves Pulmonary Function After 48 Hours of Ischemia. Ann Thorac Surg 64:795–800

    Article  PubMed  CAS  Google Scholar 

  95. Kirk AJB, Colquhoun IW, Dark JH (1993) Lung Preservation: A Review of Current Practice and Future Directions. Ann Thorac Surg 56:990–1000

    Article  PubMed  CAS  Google Scholar 

  96. Lehtola A, Harjula A, Heikkiläa L, Hämmäinen P, Taskinen E, Kurki T, Salmenperä M, Mattila S (1990) Single Lung Allotransplantation in Pigs. Transplantation 6:1066–1074

    Article  Google Scholar 

  97. Locke TJ, Hooper TL, Flecknell PA, McGregor CGA (1988) Preservation of the lung. J Thorac Cardiovasc Surg 96:789–795

    PubMed  CAS  Google Scholar 

  98. Löckinger A, Schütte H, Walmrath D, Seeger W, Grimminger F (2001) Protection against gas exchange abnormalities by pre-aerosolized PGE1, Iloprost, and Nitroprusside in lung ischemia-reperfusion. Transplantation 71:185–193

    Article  PubMed  Google Scholar 

  99. Love RB, Conhaim RL, Harms BA (1996) Effects of University of Wisconsin and Euro-Collins solutions on interstitial pulmonary edema in isolated rat lungs. Transplantation 61:1014–1018

    Article  PubMed  CAS  Google Scholar 

  100. Luh SP, Tsai CC, Shau WY, Chen JS, Kuo SH, Shiau SY, Lee YC (2000) The effects of inhaled nitric oxide, gabexate mesilate, and retrograde flush in the lung graft from non-heart beating minipig donors. Transplantation 69:2019–2027

    Article  PubMed  CAS  Google Scholar 

  101. Matsumura A, Nakahara K, Miyoshi S, Mizuta T, Akashi A, Kawashima Y (1991) Filtration coefficient in isolated preserved and reperfused canine lung. J Surg Res 50:205–211

    Article  PubMed  CAS  Google Scholar 

  102. Mayer E, Puskas JD, Cardoso PFG, Shi S, Slutsky AS, Patterson GA (1992) Reliable eighteen-hour lung preservation at 4°C and 10 °C by pulmonary artery flush after high-dose prostaglandin El-administration. J Thorac Cardiovasc Surg 103:1136–1142

    PubMed  CAS  Google Scholar 

  103. Menasche P, Termignon JL, Pradier F, Grousset C, Mouas C, Alberici G, Wei\ M, Piwnica A, Bloch G (1994) Experimental evaluation of Celsior, a new heart preservation solution. Eur J Cardiothorac Surg 8:207–213

    Article  PubMed  CAS  Google Scholar 

  104. Meyers BF, Patterson GA (2000) Current Status of Lung Transplantation. Adv Surg 34:301–318

    PubMed  CAS  Google Scholar 

  105. Mills NL, Boyd AD, Gheranpong C, Spencer FC (1970) The significance of bronchial circulation in lung transplantation. J Thorac Cardiovasc Surg 60:866–874

    PubMed  CAS  Google Scholar 

  106. Miyauchi T, Masaki T (1999) Pathophysiology of endothelin in the cardiovascular system. Annu Rev Physiol 61:391–415

    Article  PubMed  CAS  Google Scholar 

  107. Miyoshi S, Shimokawa S, Schreinemakers H, Date H, Weder W, Herper H, Cooper JD (1992) Comparison of the University of Wisconsin preservation solution and other crystalloid perfusates in a 30-hour rabbit lung preservation model. J Thorac Cardiovasc Surg 103:27–32

    PubMed  CAS  Google Scholar 

  108. Moncada S, Flower RI, Vane JR (1985) Prostaglandins, prostacyclin, thromboxane A2 and leukotrienes. In: Gilman AG, Goodman LS, Rail TW, Murad F (eds) The pharmacologic basis of therapeutics. Macmillan, New York, pp 660–673

    Google Scholar 

  109. Moriyasu K, McKeown PP, Novitzky D, Snow TR (1995) Preservation of Competent Rabbit Lung Function after 30 Hours of Storage with a Low-potassium Dextran Solution. J Heart Lung Transplant 14:75–79

    PubMed  CAS  Google Scholar 

  110. Müller C, Bittmann I, Hatz R, Kellner B, Schelling G, Fürst H, Reichart B, Schildberg FW (2002) Improvement of Lung Preservation — From Experiment to Clinical Practice. Eur Surg Res 34:77–82

    PubMed  Google Scholar 

  111. Müller C, Fürst H, Reichenspurner H, Briegel J, Groh J, Reichart B (1999) Lung procurement by low-potassium dextran and the effect on preservation injury. Transplantation 68:1139–1143

    Article  PubMed  Google Scholar 

  112. Müller C, Hoffmann H, Bittmann I, Isselhard W, Messmer K, Dienemann H, Schildberg FW (1997) Hypothermic storage alone in lung preservation for transplantation. Transplantation 63:625–630

    Article  PubMed  Google Scholar 

  113. Naka Y, Chowdhury NC, Liao H, Roy DK, Oz MC, Michler RE, Pinsky DJ (1995) Enhanced Preservation of Orthotopically Transplanted Rat Lungs by Nitroglycerin but Not Hydralazine. Circ Res 76:900–906

    PubMed  CAS  Google Scholar 

  114. Naka Y, Roy DK, Chowdhury NC, Michler RE, Oz MC, Pinsky DJ (1996) cAMP-Mediated Vascular Protection in an Orthotopic Rat Lung Transplant Model. Circ Res 79:773–783

    PubMed  CAS  Google Scholar 

  115. Nakamoto K, Maeda M, Taniguchi K, Tsubota N, Kawashima Y (1992) A Study on Optimal Temperature for Isolated Lung Preservation. Ann Thorac Surg 53:101–108

    Article  PubMed  CAS  Google Scholar 

  116. Novak K, Kamler M, Bock M, Motsch J, Hagl S, Jakob H, Gebhard MM (2002) Bronchial Artery Revascularization Affects Graft Recovery after Lung Transplantation. Am J Respir Crit Care Med 165:216–220

    Google Scholar 

  117. Novick RJ, Gehman KE, Ali IS, Lee J (1996) Lung Preservation: The Importance of Endothelial and Alveolar Type II Cell Integrity. Ann Thorac Surg 62:302–314

    Article  PubMed  CAS  Google Scholar 

  118. Novick RJ, Menkis AH, McKenzie FN (1992) New Trends in Lung Preservation: A Collective Review. J Heart Lung Transplant 11:377–392

    PubMed  CAS  Google Scholar 

  119. Oka T, Puskas JD, Mayer E, Cardoso PFG, Shi S, Wisser W, Slutsky AS, Patterson GA (1991) Low-potassium UW solution for lung preservation. Transplantation 52:984–989

    PubMed  CAS  Google Scholar 

  120. Ono K, Sone Y, Irie T, Ohnuki T, Nitta S (1998) Does potassium ion concentration affect lung preservation? Surg Today 28:192–196

    Article  PubMed  CAS  Google Scholar 

  121. Reignier J, Mazmanian M, Chapelier A, Alberici G, Menasche P, Weiss M, Herve P (1995) Evaluation of a New Preservation Solution: Celsior in the Isolated Rat Lung. J Heart Lung Transplant 14:601–604

    PubMed  CAS  Google Scholar 

  122. Rinaldi M, Martinelli L, Volpato G, Minzioni G, Goggi C, Mantovani V, Vigano M (1995) University of Wisconsin Solution Provides Better Lung Preservation in Human Lung Transplantation. Transplant Proc 27:2869–2871

    PubMed  CAS  Google Scholar 

  123. Risberg B, Smith L, Stenberg B (1985) Prevention of edema formation in the perfused lung preparation by oxygen radical scavengers. Eur Surg Res 17:230–236

    PubMed  CAS  Google Scholar 

  124. Roberts RF, Nishanian GP, Carey JN, Sakamaki Y, Starnes VA, Barr ML (1999) A comparison of the new preservation solution Celsior to Euro-Collins and University of Wisconsin solutions in lung reperfusion injury. Transplantation 67:152–155

    Article  PubMed  CAS  Google Scholar 

  125. Rosendale BE, Keenan RJ, Duncan SR, Hardesty RL, Armitage JA, Griffith BP, Yousem SA (1992) Donor Cerebral Emboli as a Cause of Acute Graft Dysfunction in Lung Transplantation. J Heart Lung Transplant 11:72–76

    PubMed  CAS  Google Scholar 

  126. Sachs SA, Petritsch PH, Kaufmann JJ (1973) Canine kidney preservation using a new perfusate. Lancet 1:1024–1028

    Article  Google Scholar 

  127. Sanchez de Leon R, Orchard CH, Chakrabarti MK, Sykes MK (1982) Effect of hypoxia on fluid filtration rate during forward and reverse perfusion of isolated rabbit lungs. Cardiovasc Res 16:711–715

    Article  PubMed  CAS  Google Scholar 

  128. Sarsam MAI, Yonan NA, Deiraniya AK, Rahman AN (1993) Retrograde Pulmonary plegia for Lung Preservation in Clinical Transplantation: A New Technique. J Heart Lung Transplant 12:494–498

    PubMed  CAS  Google Scholar 

  129. Sasaki M, Muraoke R, Chiba Y, Hiramatu Y (1996) Influence of pulmonary arterial pressure during flushing on lung preservation. Transplantation 61:22–27

    Article  PubMed  CAS  Google Scholar 

  130. Schneuwly OD, Licker M, Pastor CM, Schweizer A, Slosman DO, Kapanci Y, Nicod LP, Robert J, Spiliopoulos A, Morel DR (1999) Beneficial Effects of Leukocyte-depleted Blood and Low-potassium Dextran Solutions on Microvascular Permeability in Preserved Porcine Lung. Am J Respir Crit Care Med 160:689–697

    PubMed  CAS  Google Scholar 

  131. Scott RS, Baumgartner WA, Borkon AM (1994) Successful 4-hour hypothermic lung storage with Euro-Collins solution: a simplified model assessing preservation. Heart Transplant 3:346–349

    Google Scholar 

  132. Scottish Intercollegiate Guidelines Network: SIGN Guidelines 1999. An introduction to SIGN methodology for the development of evidence-based guidelines

    Google Scholar 

  133. Shiraishi T, Igisu H, Shirakusa T (1994) Effects of pH and temperature on lung preservation: a study with an isolated rat lung reperfusion model. Ann Thorac Surg 57:639–643

    Article  PubMed  CAS  Google Scholar 

  134. Singh AK, Mani H, Seth P, Gaddipati JP, Kumari R, Banuadha KK, Sharma SC, Kulshreshtha DK, Maheshwari RK (2000) Picroliv preconditioning protects the rat liver against ischemia-reperfusion injury. Eur J Pharmacol 395:229–239

    Article  PubMed  CAS  Google Scholar 

  135. Snell GI, Rabinov M, Griffiths A, Williams T, Ugoni A, Salamonsson R, Esmore D (1996) Pulmonary Allograft Ischemic Time: An Important Predictor of Survival after Lung Transplantation. J Heart Lung Transplant 15:160–168

    PubMed  CAS  Google Scholar 

  136. Spaggiari L, Alfieri R, Rusca M, Carbognani P, Cattelani L, Bobbio A, Petronini PG, Borghetti FA, Bobbio P (1998) The effect of free radical-scavenger system “N-Acetylcystein/Glutathione” for hypothermic prolonged lung cells preservation. J Cardiovasc Surg 39:253–254

    CAS  Google Scholar 

  137. Steen S, Kimblad PO, Sjöberg TT, Lindberg L, Ingemansson R, Massa G (1994) Safe Lung Preservation for Twenty-Four Hours With Perfadex. Ann Thorac Surg 57:450–457

    Article  PubMed  CAS  Google Scholar 

  138. Steen S, Sjöberg T, Ingemannsson R, Lindberg L (1994) Efficacy of Topical Cooling in Lung Preservation: Is a Reappraisal Due? Ann Thorac Surg 58:1657–1663

    Article  PubMed  CAS  Google Scholar 

  139. Steen S, Sjöberg T, Massa G, Eriksson L, Lindberg L (1993) Safe Pulmonary Preservation for 12 Hours With Low-Potassium-Dextran Solution. Ann Thorac Surg 55:434–440

    Article  PubMed  CAS  Google Scholar 

  140. Steen S, Sjöberg T, Pierre L, Liao Q, Eriksson L, Algotsson L (2001) Transplantation of lungs from a non-heart-beating donor. Lancet 357:825–829

    Article  PubMed  CAS  Google Scholar 

  141. Stewart S, Chilli F, Wells FC, Wallwork J (1993) Pathology of unused donor lungs. Transplant Proc 25:1167–1168

    PubMed  CAS  Google Scholar 

  142. Strom TB, Carpenter CB (1983) Prostaglandins as an effective antirejection therapy in rat renal allograft recipients. Transplantation 35:279–280

    PubMed  CAS  Google Scholar 

  143. Strüber M, Hohldeld JM, Fraund S, Kim P, Warnecke G, Haverich A (2000) Low-potassium dextran solution ameliorates reperfusion injury of the lung and protects surfactant function. J Thorac Cardiovasc Surg 120:566–572

    Article  PubMed  Google Scholar 

  144. Strüber M, Hohlfeld JM, Kofidis T, Warnecke G, Niedermeyer J, Sommer SP, Haverich A (2002) Surfactant function in lung transplantation after 24 hours of ischemia: advantage of retrograde flush perfusion for preservation. J Thorac Cardiovasc Surg 123:98–103

    Article  PubMed  Google Scholar 

  145. Strüber M, Wahlers T, Warnecke G, Wittwer T, Harringer W, Haverich A (1999) Celsior — a new preservation solution in the lung? Thorac Cardiovasc Surg 47(Suppl):210

    Google Scholar 

  146. Strüber M, Wilhelmi M, Harringer W, Niedermeyer J, Anssar M, Künsebeck A, Schmitto JD, Haverich A (2001) Flush perfusion with low potassium dextran solution improves early graft function in clinical lung transplantation. Eur J Cardiothorac Surg 19:190–194

    Article  PubMed  Google Scholar 

  147. Sugita M, Suzuki S, Fujimura S et al. (1997) Effects of Flushing Temperature and Preservation Solution on Alveolar Fluid Clearance in the Preserved Rat Lungs. Transplant Proc 29:1354–1356

    Article  PubMed  CAS  Google Scholar 

  148. Tanaka H, Chiba Y, Sasaki M, Matsukawa S, Muraoke R (1998) Relationship between flushing pressure and nitric oxide production in preserved lungs. Transplantation 65:460–464

    Article  PubMed  CAS  Google Scholar 

  149. Thabout G, Vinatier I, Brugiere O, Leseche G, Loirat P, Bisson A, Marty J, Fournier M, Mai H (2001) Influence of Preservation Solution on Early Graft Failure in Clinical Lung Transplantation. Am J Resp Crit Care Med 164:1204–1208

    Google Scholar 

  150. Trulock EP, Edwards LB, Taylor DO, Boucek MM, Mohacsi PJ, Keck BM, Hertz MI (2003) The Registry of the International Society for Heart and Lung Transplantation: Twentieth Official adult lung and heart-lung transplant report 2003. J Heart Lung Transplant 22:625–635

    Article  PubMed  Google Scholar 

  151. Ueno T, Yokomise H, Oka T, Puskas J, Mayer E, Slutsky AS, Patterson GA (1991) The effect of PGE1 and temperature on lung function following preservation. Transplantation 52:626–630

    PubMed  CAS  Google Scholar 

  152. Vane JR (1983) Adventures and excursions in bioassay — the steping stones to prostacyclin. Postgrad Med J 59:743–758

    Article  PubMed  CAS  Google Scholar 

  153. Vedrinne JM, Guillaume C, Gagnieu MC, Gratadour P, Pleuret C, Motin J (1992) Bronchoalveolar lavage in trauma patients for diagnosis of fat embolism syndrome. Chest 102:1323–1327

    PubMed  CAS  Google Scholar 

  154. Venuta F, Rendina EA, Bufi M, Delia Rocca G, Giacomo TD, Costa MG, Pugliese F, Coccia C, Ciccone AM, Coloni GF (1999) Preimplantation retrograde pneumoplegia in clinical lung transplantation. J Thorac Cardiovasc Surg 118:107–114

    Article  PubMed  CAS  Google Scholar 

  155. Wada H, Liu CJ, Hirata T, Bando T, Kosaka S (1996) Effective 30-Hour Preservation of Canine Lungs With Modified ET-Kyoto Solution. Ann Thorac Surg 61:1099–1105

    Article  PubMed  CAS  Google Scholar 

  156. Wahlers T, Haverich A, Fieguth HG, Schäfers HJ, Takayama T, Borst HG (1986) Flush perfusion using Euro-Collins solution versus cooling by means of extracorporeal circulation in heart-lung preservation. J Heart Lung Transplant 5:89–98

    CAS  Google Scholar 

  157. Waller DA, Bennett MK, Corris PA, Dark JH (1995) Donor-Acquired Fat Embolism Causing Primary Organ Failure After Lung Transplantation. Ann Thorac Surg 59:1565–1566

    Article  PubMed  CAS  Google Scholar 

  158. Wang LS, Nakamoto K, Hsieh CM, Miyoshi S, Cooper JD (1993) Influence of Temperature of Flushing Solution on Lung Preservation. Ann Thorac Surg 55:711–715

    Article  PubMed  CAS  Google Scholar 

  159. Wang LS, Yoshikawa K, Miyoshi S, Nakamoto K, Hsieh CM, Yamazaki F, Cardoso PFG, Schäfers HJ, Brito J, Keshavjee SH, Patterson A, Cooper JD (1989) The effect of ischemic time and temperature on lung preservation in a simple ex vivo rabbit model used for functional assessment. J Thorac Cardiovasc Surg 98:333–342

    PubMed  CAS  Google Scholar 

  160. Weder W, Harper B, Shimokawa S (1991) Influence of intraalveolar oxygen concentration on lung preservation in a rabbit model. J Thorac Cardiovasc Surg 101:1037

    PubMed  CAS  Google Scholar 

  161. Wittwer T, Cornelius JF, Elki S, Wahlers T (1999) Celsior solution for Improvement of currently used clinical standards of Lung Preservation in an Ex Vivo Rat Model. Eur J Cardio Surg 15:667–671

    Article  CAS  Google Scholar 

  162. Wittwer T, Fehrenbach A, Meyer D, Brandes H, Albes J, Richter J, Wahlers T (2000) Retrograde Flush Perfusion with Low-Potassium Solutions for Improvement of Experimental Pulmonary Preservation. J Heart Lung Transplant 19:976–983

    Article  PubMed  CAS  Google Scholar 

  163. Wittwer T, Franke U, Fehrenbach A, Ochs M, Sandhaus T, Schuette A, Richter S, Dreyer N, Knudsen L, Müller T, Schubert H, Richter J, Wahlers T (2004) Experimental Lung Transplantation — Impact of Preservation Solution and Route of Delivery. J Heart Lung Transplant, submitted

    Google Scholar 

  164. Wittwer T, Franke UFW, Fehrenbach A, Ochs M, Sandhaus T, Schuette A, Richter S, Dreyer N, Knudsen L, Müller T, Schubert H, Richter J, Wahlers T (2004) Donor Pretreatment Using The Aerosolized Prostacyclin Analogue Iloprost Optimizes Postischemic Function of Non Heart Beating Donor Lungs. J Heart Lung Transplant, in press

    Google Scholar 

  165. Wittwer T, Pethig K, Strüber M, Höper M, Harringer W, Haverich A, Franke U, Wahlers T (2001) Aerosolized Iloprost for Severe Pulmonary Hypertension as a Bridge to Heart Transplantation. Ann Thorac Surg 71:1004–1006

    Article  PubMed  CAS  Google Scholar 

  166. Wittwer T, Wahlers T, Fehrenbach A, Elki S, Haverich A (1999) Improvement of Pulmonary Preservation with Celsior and Perfadex: Impact of Storage Time on Early Postischemic Lung Function. J Heart Lung Transplant 18:1198–1201

    Article  PubMed  CAS  Google Scholar 

  167. Wittwer T, Wahlers T, Fehrenbach A, Ochs M, Fehrenbach H, Cornelius JF, Elki S, Richter J, Haverich A (1999) Combined use of prostacyclin and higher perfusate temperatures further enhances the superior lung preservation by Celsior solution in the isolated rat lung. J Heart Lung Transplant 18:684–692

    Article  PubMed  CAS  Google Scholar 

  168. Woolley DS, Devito-Haynes LD, Ulschmid S, Leverson G, Welter DL, Hoffmann A, Cromwell RD, Burlingham WJ, Meyer KC, Love RB (2001) Extended lung preservation with UW solution does not adversely affect graft outcome. J Heart Lung Transplant 20:207

    Article  PubMed  Google Scholar 

  169. Wright NC, Hopkinson DN, Shaw TE, Hooper TL (2000) 24-hour lung preservation: simplified versus conventional University of Wisconsin solution in a porcine model. Transplantation 69:1261–1265

    Article  PubMed  CAS  Google Scholar 

  170. Wu G, Zhang F, Salley RK, Robinson MC, Chien S (1996) A systematic study of hypothermic lung preservation solutions: Euro-Collins Solution. Ann Thorac Surg 62:356–362

    Article  PubMed  CAS  Google Scholar 

  171. Yacoub MH, Khagani A, Banner N (1989) Distant organ procurement for heart and lung transplantation. Transplant Proc 21:2548–2550

    PubMed  CAS  Google Scholar 

  172. Zenati M, Dowling RD, Armitage JM, Kormos RL, Dummer JS, Hardesty RL, Griffith BP (1989) Organ procurement for pulmonary transplantation. Ann Thorac Surg 48:882–886

    Article  PubMed  CAS  Google Scholar 

  173. Zhang F, Salley R (1994) Effect of glutathione on hypothermic lung preservation. Acta Biomed Ateneo Parmense 65:199–211

    PubMed  CAS  Google Scholar 

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Wittwer, T., Wahlers, T. (2006). Empfehlungen zur Lungenkonservierung. In: Feindt, P., Harig, F., Weyand, M. (eds) Empfehlungen zum Einsatz und zur Verwendung der Herz-Lungen-Maschine. Steinkopff. https://doi.org/10.1007/3-7985-1646-4_25

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