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Research and Technological Innovation pp 201–224Cite as

The Locational Dynamics of the U.S. Biotech Industry: Knowledge Externalities and the Anchor Hypothesis

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Keywords

  • Knowledge Spillover
  • Locational Dynamics
  • Shopping Mall
  • Location Quotient
  • Small Business Economic

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  • Adams J, Chiang E, Starkey K (2001) Industry-University Cooperative Research Centers. Journal of Technology Transfer 26: 73–86.

    CrossRef  Google Scholar 

  • Agrawal A, Cockburn I (2002) University Research, Industrial R&D, and the Anchor Tenant Hypothesis

    Google Scholar 

  • Almeida P, Kogut B (1997) The Exploration of Technological Diversity and the Geographic Localization of Innovation. Small Business Economics 9(1): 21–31.

    CrossRef  Google Scholar 

  • Audretsch D, Feldman M (1996) R&D Spillovers and the Geography of Innovation and Production. American Economic Review 86(4): 253–273.

    Google Scholar 

  • Audretsch D, Stephan P (1996) Company-Scientist Locational Links: The Case of Biotechnology. American Economic Review 86(4): 641–652.

    Google Scholar 

  • Autant-Bernard CP (2000) Science and Knowledge Flows: Evidence from the French Case. Research Policy 30: 1069–1078.

    CrossRef  Google Scholar 

  • Baptista R, Swann P (1996) A comparison of clustering dynamics in the US and UK computer industries. Paper presented at the 6th International Joseph A. Schumpeter Conference, Stockholm, June, and at the 23rd EARIE Conference, Vienna, September.

    Google Scholar 

  • Barnes M, Mowery DC, Ziedonis AA (1997) The Geographic Reach of Market and Non-market Channels of Technology Transfer: Comparing Citations and Licenses of University Patents. Paper presented at the Academy of Management.

    Google Scholar 

  • Beardsell M, Henderson V (1999) Spatial evolution of the computer industry. European Economic Review 43: 431–56.

    CrossRef  Google Scholar 

  • Bhide AV (1999) The Origin and Evolution of New Businesses. Oxford University Press, Oxford.

    Google Scholar 

  • Biotechnology Industry Organization (2001) State Government Initiatives in Biotechnology 2001, Washington, D.C. http://www.bio.org/tax/battelle.pdf.

    Google Scholar 

  • Bresnahan TF, Greenstein S (1996) Technical Progress and Co-invention in Computing and in the Uses of Computers. Brookings-Papers-on-Economic-Activity. Microeconomics 1996: 1–77.

    Google Scholar 

  • Bresnahan TF, Greenstein S (2001) The Economic Contribution of Information Technology: Towards Comparative and User Studies. Journal-of-Evolutionary-Economics 11: 95–118.

    CrossRef  Google Scholar 

  • Bresnahan TF, Trajtenberg M (1995) General Purpose Technologies: ‘Engines of Growth’? Journal-of-Econometrics 65: 83–108

    CrossRef  Google Scholar 

  • Caniëls M, Verspagen B (2001) Barriers to knowledge spillovers and regional convergence in an evolutionary model. Journal of Evolutionary Economics 11: 307–329.

    CrossRef  Google Scholar 

  • Cohen W, Levinthal D (1989) Innovation and Learning: The Two Faces of R&D. The Economic Journal 99: 569–596.

    CrossRef  Google Scholar 

  • Cortright J, Mayer H (2002) Signs of Life: The Growth of Biotechnology Centers in the U.S. The Brookings Institution; Washington, DC.

    Google Scholar 

  • Criscuolo P, Rajneesh N (2002) A novel Approach to National Technological Accumulation and Absorptive Capacity: Aggregating Cohen and Levinthal. Conference Paper for DRUID’s New Economy Conference, June.

    Google Scholar 

  • Dalum B, Laursen K, Verspagen B (1999) Does Specialization Matter for Growth?. Industrial and Corporate Change 8:2:267–288.

    CrossRef  Google Scholar 

  • Dasgupta P, David P (1987) Information Disclosure and the Economics of Science and Technology. In: Arrow and the ascent of modern economic theory, Ed: George R. Feiwel. New York: New York University Press, pp. 519–94.

    Google Scholar 

  • Durnaton G, Puga D (2001) Nursery Cities: Urban Diversity, Process Innovation and the Life Cycle of Products. American Economic Review 91:5:1454–1477.

    CrossRef  Google Scholar 

  • Eppli MJ, Shilling JD (1995) Large-Scale Shopping Center Development Opportunities. Land-Economics 71:1:35–41 (February).

    CrossRef  Google Scholar 

  • Feldman M (2000) Location and Innovation: The new economics of innovation, spillovers and agglomeration. In: Clark G, Feldman M, Gertler M (eds), The Oxford Handbook of Economic Geography. Oxford: Oxford University Press, 373–394.

    Google Scholar 

  • Feldman M (2001) The Entrepreneurial Event Revisited: Firm Formation in a Regional Context. Industrial and Corporate Change 10(4):861–891.

    CrossRef  Google Scholar 

  • Feldman M, Audretsch D (1999) Innovation in Cities: Science-Based Diversity, Specialization and Localized Competition. European Economic Review 43: 409–429

    CrossRef  Google Scholar 

  • Feldman M, Francis J (2002) The Biotech Capitol Cluster. (August)

    Google Scholar 

  • Feldman M, Ronzio CR (2001) Closing the innovative loop: Moving from the lab to the shop floor in biotech. Innovation and Entrepreneurship 13: 1–16.

    Google Scholar 

  • Gatzlaf DH, Sirmans S, Diskin B (1994) The Effect of Anchor Tenant Loss on Shopping Center Rents. Journal-of-Real-Estate-Research 9(1): 99–110 (Winter).

    Google Scholar 

  • Geiger R, Feller I (1995) The Dispersion of Academic Research in the 1980s. Journal of Higher Education 66(3): 336–360.

    CrossRef  Google Scholar 

  • Glaeser E, Kallal H, Scheinkman J, Shleifer A (1992) Growth of Cities. Journal of Political Economy 100: 1126–1152.

    CrossRef  Google Scholar 

  • Goetz SJ, Morgan RS (1995) State Level Locational Determinants of Biotechnology Firms. Economic Development Quarterly 9(2): 174–85.

    CrossRef  Google Scholar 

  • Gray M, Parker E (1998) Industrial change and regional development: The case of the U.S. pharmaceutical industries. Environment and Planning 30(10): 1757–1774.

    CrossRef  Google Scholar 

  • Greis N, Dibner M, Bean A (1995) External partnering as a response to innovation barriers and global competition in biotechnology. Research Policy 24: 609–630.

    CrossRef  Google Scholar 

  • Hall BH, Jaffe AB, Tratjenberg M (2001) The NBER Patent Citation Data File: Lessons, Insights and Methodological Tools. NBER Working Paper 8498.

    Google Scholar 

  • Hall L (2001) An Analysis of R&D, Innovation, and Business Performance in the U.S. Biotechnology Industry. International Journal of Biotechnology 3(3): 1–10.

    Google Scholar 

  • Henderson V, Kuncoro A, Turner M (1995) Industrial Development in Cities. Journal of Political Economy 103(5): 1067–1090.

    CrossRef  Google Scholar 

  • Kenney MP (1986) Biotechnology: The University-Industrial Complex. Yale University Press: New Haven, CT, pp: 9–27.

    Google Scholar 

  • Kenney M, Von Burg U (1999) Technology and path dependence: the divergence between Silicon Valley and Route 128. Industrial and Corporate Change 8(1): 67–103.

    CrossRef  Google Scholar 

  • Klepper S (2001) The Evolution of the U.S. Automobile Industry and Detroit as its Capital. (November).

    Google Scholar 

  • Mansfield, Edwin (1995) Academic Research Underlying Industrial Innovations: Sources, Characteristics, and Financing Review-of-Economics-and-Statistics, 77: 55–65.

    CrossRef  Google Scholar 

  • Orlando MP (2000) On the Importance of Geographic and Technological Proximity for R&D Spillover: An Empirical Investigation. Federal Reserve Bank of Kansas City.

    Google Scholar 

  • Orsenigo L (2001) The (Failed) Development of a Biotechnology Cluster: The Case of Lombardy. Small Business Economics, 17: 81–82.

    CrossRef  Google Scholar 

  • Pashigan P, Gould E (1998) Internalizing Externalities: The Pricing of Space in Shopping Malls. Journal of Law and Economics, XLI: 115–142.

    CrossRef  Google Scholar 

  • Powell W, Brantley P (1992) Competitive cooperation in biotechnology: learning through networks?. In: Nohria N, Eccles RG (eds), Networks and Organizations: Structure, Form and Action. Harvard Business School Press: Boston, MA, pp: 366–394.

    Google Scholar 

  • Prevezer M (1997) The dynamics of industrial clustering in biotechnology, Small Business Economics 9: 255–271.

    CrossRef  Google Scholar 

  • Prevezer M, Toker S (1996) The degree of integration in strategic alliances in biotechnology. Technology Analysis & Strategic Management 8(2): 117–133.

    CrossRef  Google Scholar 

  • Raider H (1998) Repeated Exchange and Evidence of Trust in the Substance Contract. Working paper, Columbia University.

    Google Scholar 

  • Rifkin J (1998) The Biotech Century: Harnessing the Gene and Remaking the World. Jeremy Tarcher Putnam, New York, NY.

    Google Scholar 

  • Rosenthal S, Strange W Geography, Industrial Organization, and Agglomeration. Review of Economics and Statistics (forthcoming).

    Google Scholar 

  • Scherer FM (1999) New Perspectives on economic Growth and Technological Innovation. Washington: Brookings Institution Press.

    Google Scholar 

  • Siegel D, Waldman D, Link A (1999) Assessing the Impact of Organizational Practices on the Productivity of University Technology Transfer Offices: An Exploratory Study. Working Paper 7256. Cambridge, MA: National Bureau of Economic Research.

    Google Scholar 

  • Sorenson O, Audia P (2000) The Social Structure of Entrepreneurial Activity: Geographic Concentration of Footwear Production in the United States, 1940—1989. American Journal of Sociology 106(2): 324–362.

    CrossRef  Google Scholar 

  • Stephan PE (1996) The Economics of Science. Journal of Economic Literature 34:3.

    Google Scholar 

  • Swann P, Prevezer M (1996) A Comparison of the Dynamics of Industrial Clustering in Computing and Biotechnology. Research Policy 25: 1139–1157.

    CrossRef  Google Scholar 

  • Toole A (forthcoming) Understanding Entrepreneurship in U.S. Biotechnology: What are its characteristics, facilitating factors, and policy challenges?. In: David Hart ed. The Emergence of Entrepreneurship Policy: Governance, Start-Ups, and Growth in the Knowledge Economy. Cambridge, U.K.: Cambridge University Press (forthcoming).

    Google Scholar 

  • Von Hippel E (1994) Sticky Information and the Locus of Problem Solving: Implications for Innovation. Management Science 40: 429–439.

    CrossRef  Google Scholar 

  • Watson JP (1981) The Double Helix: A Personal Account of the Discovery of the Structure of DNA. Norton; New York, NY

    Google Scholar 

  • Zeller C (2001) Clustering Biotech: A Recipe for Success? Spatial Patterns of Growth of Biotechnology in Munich, Rhineland and Hamburg. Small Business Economics 17: 123–141.

    CrossRef  Google Scholar 

  • Zucker LG, Darby MR (1996) Star scientists and institutional transformation: Patterns of invention and innovation in the formation of the biotechnology industry. Proceedings of the National Academy of Science 93: 12709–12716 (November).

    CrossRef  CAS  ADS  Google Scholar 

  • Zucker LG, Darby MR (1997) The Economist’s Case for Biomedical Research. In: The Future of Biomedical Research, Claude E. Barfield and Bruce L. R. Smith (editors), Washington: D.C.: American Enterprise Institute and The Brookings Institution.

    Google Scholar 

  • Zucker LG, Darby MR, Brewer MB (1997) Intellectual human capital and the birth of U.S. biotechnology enterprises. American Economic Review 88(1): 290–306.

    Google Scholar 

  • Zucker LG, Darby MR, Armstrong J (1998) Intellectual Capital and the Firm: The Technology of Geographically Localized Knowledge Spillovers. Economic Inquiry 36: 65–86.

    CrossRef  Google Scholar 

  • Zucker LG, Darby MR, Armstrong J (2002) Commercializing Knowledge: University Science, Knowledge Capture and Firm Performance in Biotechnology. Management Science 48(1): 138–153.

    CrossRef  Google Scholar 

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Author information

Authors and Affiliations

  1. Rotman School of Management, University of Toronto, 105 St. George St., Toronto, ON, M5S 3E6, Canada

    Maryann Feldman

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  1. Maryann Feldman
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Editor information

Editors and Affiliations

  1. Research Centre CRANEC, Università Cattolica, Via Necchi, 5, 20123, Milano, Italy

    Alberto Quadrio Curzio

  2. Edison S.p.A., Foro Buonaparte, 31, 20121, Milano, Italy

    Marco Fortis

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Feldman, M. (2005). The Locational Dynamics of the U.S. Biotech Industry: Knowledge Externalities and the Anchor Hypothesis. In: Quadrio Curzio, A., Fortis, M. (eds) Research and Technological Innovation. Physica-Verlag HD. https://doi.org/10.1007/3-7908-1658-2_9

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