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Toll-like receptors as key sensors of viral infection

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Toll-like Receptors in Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

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References

  1. Ahonen CL, Doxsee CL, McGurran SM, Riter TR, Wade WF, Barth RJ, Vasilakos JP, Noelle RJ, Kedl RM (2004) Combined TLR and CD40 triggering induces potent CD8+ T cell expansion with variable dependence on type I IFN. J Exp Med 199: 775–784

    Article  PubMed  CAS  Google Scholar 

  2. Kurt-Jones EA, Popova L, Kwinn L, Haynes LM, Jones LP, Tripp RA, Walsh EE, Freeman MW, Golenbock DT, Anderson LJ et al (2000) Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol 1: 398–401

    Article  PubMed  CAS  Google Scholar 

  3. Haynes LM, Moore DD, Kurt-Jones EA, Finberg RW, Anderson LJ, Tripp RA (2001) Involvement of toll-like receptor 4 in innate immunity to respiratory syncytial virus. J Virol 75: 10730–10737

    Article  PubMed  CAS  Google Scholar 

  4. Poltorak A, Merlin T, Nielsen PJ, Sandra O, Smirnova I, Schupp I, Boehm T, Galanos C, Freudenberg MA (2001) A point mutation in the IL-12R beta 2 gene underlies the IL-12 unresponsiveness of Lps-defective C57BL/10ScCr mice. J Immunol 167: 2106–2111

    PubMed  CAS  Google Scholar 

  5. Haeberle HA, Takizawa R, Casola A, Brasier AR, Dieterich HJ, Van Rooijen N, Gatalica Z, Garofalo RP (2002) Respiratory syncytial virus-induced activation of nuclear factor-kappaB in the lung involves alveolar macrophages and toll-like receptor 4-dependent pathways. J Infect Dis 186: 1199–1206

    Article  PubMed  CAS  Google Scholar 

  6. Monick MM, Yarovinsky TO, Powers LS, Butler NS, Carter AB, Gudmundsson G, Hunninghake GW (2003) Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin. J Biol Chem 278: 53035–53044

    Article  PubMed  CAS  Google Scholar 

  7. van der Sluijs KF, van Elden L, Nijhuis M, Schuurman R, Florquin S, Jansen HM, Lutter R, van der Poll T (2003) Toll-like receptor 4 is not involved in host defense against respiratory tract infection with Sendai virus. Immunol Lett 89: 201–206

    PubMed  Google Scholar 

  8. Gagro A, Tominac M, Krsulovic-Hresic V, Bace A, Matic M, Drazenovic V, Mlinaric-Galinovic G, Kosor E, Gotovac K, Bolanca I et al (2004) Increased Toll-like receptor 4 expression in infants with respiratory syncytial virus bronchiolitis. Clin Exp Immunol 135: 267–272

    Article  PubMed  CAS  Google Scholar 

  9. Ehl S, Bischoff R, Ostler T, Vallbracht S, Schulte-Monting J, Poltorak A, Freudenberg M (2004) The role of Toll-like receptor 4 versus interleukin-12 in immunity to respiratory syncytial virus. Eur J Immunol 34: 1146–1153

    Article  PubMed  CAS  Google Scholar 

  10. Tal G, Mandelberg A, Dalal I, Cesar K, Somekh E, Tal A, Oron A, Itskovich S, Ballin A, Houri S et al (2004) Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease. J Infect Dis 189: 2057–2063

    Article  PubMed  CAS  Google Scholar 

  11. Triantafilou K, Triantafilou M (2004) Coxsackievirus B4-induced cytokine production in pancreatic cells is mediated through toll-like receptor 4. J Virol 78: 11313–11320

    Article  PubMed  CAS  Google Scholar 

  12. Satoh M, Nakamura M, Akatsu T, Shimoda Y, Segawa I, Hiramori K (2004) Toll-like receptor 4 is expressed with enteroviral replication in myocardium from patients with dilated cardiomyopathy. Lab Invest 84: 173–181

    Article  PubMed  CAS  Google Scholar 

  13. Compton T, Kurt-Jones EA, Boehme KW, Belko J, Latz E, Golenbock DT, Finberg RW (2003) Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2. J Virol 77: 4588–4596

    Article  PubMed  CAS  Google Scholar 

  14. Rassa JC, Ross SR (2003) Viruses and Toll-like receptors. Microbes Infect 5: 961–968

    Article  PubMed  CAS  Google Scholar 

  15. Zhou S, Kurt-Jones EA, Mandell L, Cerny A, Chan M, Golenbock DT, Finberg RW (2005) MyD88 is critical for the development of innate and adaptive immunity during acute lymphocytic choriomeningitis virus infection. Eur J Immunol 35: 822–830

    PubMed  CAS  Google Scholar 

  16. Dolganiuc A, Oak S, Kodys K, Golenbock DT, Finberg RW, Kurt-Jones E, Szabo G (2004) Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation. Gastroenterology 127: 1513–1524

    Article  PubMed  CAS  Google Scholar 

  17. Kurt-Jones EA, Chan M, Zhou S, Wang J, Reed G, Bronson R, Arnold MM, Knipe DM, Finberg RW (2004) Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis. Proc Natl Acad Sci USA 101: 1315–1320

    Article  PubMed  CAS  Google Scholar 

  18. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA (2001) Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413: 732–738

    Article  PubMed  CAS  Google Scholar 

  19. Tabeta K, Georgel P, Janssen E, Du X, Hoebe K, Crozat K, Mudd S, Shamel L, Sovath S, Goode J et al (2004) Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc Natl Acad Sci USA 101: 3516–3521

    Article  PubMed  CAS  Google Scholar 

  20. Guillot L, Le Goffic R, Bloch S, Escriou N, Akira S, Chignard M, Si-Tahar M (2005) Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus. J Biol Chem 280: 5571–5580

    PubMed  CAS  Google Scholar 

  21. Rudd BD, Burstein E, Duckett CS, Li X, Lukacs NW (2005) Differential role for TLR3 in respiratory syncytial virus-induced chemokine expression. J Virol 79: 3350–3357

    Article  PubMed  CAS  Google Scholar 

  22. Ashkar AA, Yao XD, Gill N, Sajic D, Patrick AJ, Rosenthal KL (2004) Toll-like receptor (TLR)-3, but not TLR4, agonist protects against genital herpes infection in the absence of inflammation seen with CpG DNA. J Infect Dis 190: 1841–1849

    Article  PubMed  CAS  Google Scholar 

  23. Doyle SE, O’Connell R, Vaidya SA, Chow EK, Yee K, Cheng G (2003) Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor 4. J Immunol 170: 3565–3571

    PubMed  CAS  Google Scholar 

  24. Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K et al (2000) A Toll-like receptor recognizes bacterial DNA. Nature 408: 740–745

    PubMed  CAS  Google Scholar 

  25. Lund J, Sato A, Akira S, Medzhitov R, Iwasaki A (2003) Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med 198: 513–520

    Article  PubMed  CAS  Google Scholar 

  26. Krug A, Luker GD, Barchet W, Leib DA, Akira S, Colonna M (2004) Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9. Blood 103: 1433–1437

    PubMed  CAS  Google Scholar 

  27. Honda K, Yanai H, Negishi H, Asagiri M, Sato M, Mizutani T, Shimada N, Ohba Y, Takaoka A, Yoshida N et al (2005) IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 434: 772–777

    PubMed  CAS  Google Scholar 

  28. Latz E, Schoenemeyer A, Visintin A, Fitzgerald KA, Monks BG, Knetter CF, Lien E, Nilsen NJ, Espevik T, Golenbock DT (2004) TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat Immunol 5: 190–198

    Article  PubMed  CAS  Google Scholar 

  29. Ahmad-Nejad P, Hacker H, Rutz M, Bauer S, Vabulas RM, Wagner H (2002) Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur J Immunol 32: 1958–1968

    Article  PubMed  CAS  Google Scholar 

  30. Abe T, Takahashi H, Hamazaki H, Miyano-Kurosaki N, Matsuura Y, Takaku H (2003) Baculovirus induces an innate immune response and confers protection from lethal influenza virus infection in mice. J Immunol 171: 1133–1139

    PubMed  CAS  Google Scholar 

  31. Gronowski AM, Hilbert DM, Sheehan KC, Garotta G, Schreiber RD (1999) Baculovirus stimulates antiviral effects in mammalian cells. J Virol 73: 9944–9951

    PubMed  CAS  Google Scholar 

  32. Abe T, Hemmi H, Miyamoto H, Moriishi K, Tamura S, Takaku H, Akira S, Matsuura Y (2005) Involvement of the Toll-like receptor 9 signaling pathway in the induction of innate immunity by baculovirus. J Virol 79: 2847–2858

    Article  PubMed  CAS  Google Scholar 

  33. Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S (2002) Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol 3: 196–200

    Article  PubMed  CAS  Google Scholar 

  34. Jurk M, Heil F, Vollmer J, Schetter C, Krieg AM, Wagner H, Lipford G, Bauer S (2002) Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat Immunol 3: 499

    Article  PubMed  CAS  Google Scholar 

  35. Lee J, Chuang TH, Redecke V, She L, Pitha PM, Carson DA, Raz E, Cottam HB (2003) Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci USA 100: 6646–6651

    PubMed  CAS  Google Scholar 

  36. Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S, Lipford G, Wagner H, Bauer S (2004) Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303: 1526–1529

    Article  PubMed  CAS  Google Scholar 

  37. Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C (2004) Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303: 1529–1531

    Article  PubMed  CAS  Google Scholar 

  38. Lund JM, Alexopoulou L, Sato A, Karow M, Adams NC, Gale NW, Iwasaki A, Flavell RA (2004) Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc Natl Acad Sci USA 101: 5598–5603

    Article  PubMed  CAS  Google Scholar 

  39. Kariko K, Ni H, Capodici J, Lamphier M, Weissman D (2004) mRNA is an endogenous ligand for Toll-like receptor 3. J Biol Chem 279: 12542–12550

    PubMed  CAS  Google Scholar 

  40. Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T (2004) The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol 5: 730–737

    Article  PubMed  CAS  Google Scholar 

  41. Sumpter R Jr, Loo YM, Foy E, Li K, Yoneyama M, Fujita T, Lemon SM, Gale M Jr (2005) Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I. J Virol 79: 2689–2699

    Article  PubMed  CAS  Google Scholar 

  42. Andrejeva J, Childs KS, Young DF, Carlos TS, Stock N, Goodbourn S, Randall RE (2004) The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter. Proc Natl Acad Sci USA 101: 17264–17269

    Article  PubMed  CAS  Google Scholar 

  43. Williams BR (2001) Signal integration via PKR. Sci STKE 2001: RE2

    Google Scholar 

  44. Gil J, Garcia MA, Gomez-Puertas P, Guerra S, Rullas J, Nakano H, Alcami J, Esteban M (2004) TRAF family proteins link PKR with NF-kappa B activation. Mol Cell Biol 24: 4502–4512

    Article  PubMed  CAS  Google Scholar 

  45. Silva AM, Whitmore M, Xu Z, Jiang Z, Li X, Williams BR (2004) Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation. J Biol Chem 279: 37670–37676

    Article  PubMed  CAS  Google Scholar 

  46. Smith EJ, Marie I, Prakash A, Garcia-Sastre A, Levy DE (2001) IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein. J Biol Chem 276: 8951–8957

    PubMed  CAS  Google Scholar 

  47. Horng T, Barton GM, Medzhitov R (2001) TIRAP: an adapter molecule in the Toll signaling pathway. Nat Immunol 2: 835–841

    Article  PubMed  CAS  Google Scholar 

  48. Jiang Z, Zamanian-Daryoush M, Nie H, Silva AM, Williams BR, Li X (2003) Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR. J Biol Chem 278: 16713–16719

    PubMed  CAS  Google Scholar 

  49. Matsumoto M, Funami K, Tanabe M, Oshiumi H, Shingai M, Seto Y, Yamamoto A, Seya T (2003) Subcellular localization of Toll-like receptor 3 in human dendritic cells. J Immunol 171: 3154–3162

    PubMed  CAS  Google Scholar 

  50. Matsumoto M, Kikkawa S, Kohase M, Miyake K, Seya T (2002) Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling. Biochem Biophys Res Commun 293: 1364–1369

    Article  PubMed  CAS  Google Scholar 

  51. Funami K, Matsumoto M, Oshiumi H, Akazawa T, Yamamoto A, Seya T (2004) The cytoplasmic ‘linker region’ in Toll-like receptor 3 controls receptor localization and signaling. Int Immunol 16: 1143–1154

    Article  PubMed  CAS  Google Scholar 

  52. Schulz O, Diebold SS, Chen M, Naslund TI, Nolte MA, Alexopoulou L, Azuma YT, Flavell RA, Liljestrom P, Reis e Sousa C (2005) Toll-like receptor 3 promotes cross-priming to virus-infected cells. Nature 433: 887–892

    Article  PubMed  CAS  Google Scholar 

  53. Chen M, Barnfield C, Naslund TI, Fleeton MN, Liljestrom P (2005) MyD88 expression is required for efficient cross-presentation of viral antigens from infected cells. J Virol 79: 2964–2972

    PubMed  CAS  Google Scholar 

  54. Fujimoto C, Nakagawa Y, Ohara K, Takahashi H (2004) Polyriboinosinic polyribocytidylic acid [poly(I:C)]/TLR3 signaling allows class I processing of exogenous protein and induction of HIV-specific CD8+ cytotoxic T lymphocytes. Int Immunol 16: 55–63

    PubMed  CAS  Google Scholar 

  55. Rassa JC, Meyers JL, Zhang Y, Kudaravalli R, Ross SR (2002) Murine retroviruses activate B cells via interaction with toll-like receptor 4. Proc Natl Acad Sci USA 99: 2281–2286

    Article  PubMed  CAS  Google Scholar 

  56. Burzyn D, Rassa JC, Kim D, Nepomnaschy I, Ross SR, Piazzon I (2004) Toll-like receptor 4-dependent activation of dendritic cells by a retrovirus. J Virol 78: 576–584

    Article  PubMed  CAS  Google Scholar 

  57. Jude BA, Pobezinskaya Y, Bishop J, Parke S, Medzhitov RM, Chervonsky AV, Golovkina TV (2003) Subversion of the innate immune system by a retrovirus. Nat Immunol 4: 573–578

    Article  PubMed  CAS  Google Scholar 

  58. Bieback K, Lien E, Klagge IM, Avota E, Schneider-Schaulies J, Duprex WP, Wagner H, Kirschning CJ, Ter Meulen V, Schneider-Schaulies S (2002) Hemagglutinin protein of wild-type measles virus activates toll-like receptor 2 signaling. J Virol 76: 8729–8736

    Article  PubMed  CAS  Google Scholar 

  59. Bafica A, Scanga CA, Schito ML, Hieny S, Sher A (2003) Cutting edge: in vivo induction of integrated HIV-1 expression by mycobacteria is critically dependent on Toll-like receptor 2. J Immunol 171: 1123–1127

    PubMed  CAS  Google Scholar 

  60. Bafica A, Scanga CA, Equils O, Sher A (2004) The induction of Toll-like receptor tolerance enhances rather than suppresses HIV-1 gene expression in transgenic mice. J Leukoc Biol 75: 460–466

    PubMed  CAS  Google Scholar 

  61. Equils O, Schito ML, Karahashi H, Madak Z, Yarali A, Michelsen KS, Sher A, Arditi M (2003) Toll-like receptor 2 (TLR2) and TLR9 signaling results in HIV-long terminal repeat trans-activation and HIV replication in HIV-1 transgenic mouse spleen cells: implications of simultaneous activation of TLRs on HIV replication. J Immunol 170: 5159–5164

    PubMed  CAS  Google Scholar 

  62. Heggelund L, Muller F, Lien E, Yndestad A, Ueland T, Kristiansen KI, Espevik T, Aukrust P, Froland SS (2004) Increased expression of toll-like receptor 2 on monocytes in HIV infection: possible roles in inflammation and viral replication. Clin Infect Dis 39: 264–269

    Article  PubMed  CAS  Google Scholar 

  63. Equils O, Shapiro A, Madak Z, Liu C, Lu D (2004) Human immunodeficiency virus type 1 protease inhibitors block toll-like receptor 2 (TLR2)-and TLR4-Induced NF-kappaB activation. Antimicrob Agents Chemother 48: 3905–3911

    Article  PubMed  CAS  Google Scholar 

  64. Wang T, Town T, Alexopoulou L, Anderson JF, Fikrig E, Flavell RA (2004) Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat Med 10: 1366–1373

    PubMed  CAS  Google Scholar 

  65. Katze MG, He Y, Gale M Jr (2002) Viruses and interferon: a fight for supremacy. Nat Rev Immunol 2: 675–687

    Article  PubMed  CAS  Google Scholar 

  66. Doyle S, Vaidya S, O’Connell R, Dadgostar H, Dempsey P, Wu T, Rao G, Sun R, Haberland M, Modlin R et al (2002) IRF3 mediates a TLR3/TLR4-specific antiviral gene program. Immunity 17: 251–263

    Article  PubMed  CAS  Google Scholar 

  67. Hiscott J, Kwon H, Genin P (2001) Hostile takeovers: viral appropriation of the NF-kappaB pathway. J Clin Invest 107: 143–151

    PubMed  CAS  Google Scholar 

  68. Santoro MG, Rossi A, Amici C (2003) NF-kappaB and virus infection: who controls whom. Embo J 22: 2552–2560

    Article  PubMed  CAS  Google Scholar 

  69. Swantek JL, Tsen MF, Cobb MH, Thomas JA (2000) IL-1 receptor-associated kinase modulates host responsiveness to endotoxin. J Immunol 164: 4301–4306

    PubMed  CAS  Google Scholar 

  70. Uematsu S, Sato S, Yamamoto M, Hirotani T, Kato H, Takeshita F, Matsuda M, Coban C, Ishii KJ, Kawai T et al (2005) Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7-and TLR9-mediated interferon-{alpha} induction. J Exp Med 201: 915–923

    Article  PubMed  CAS  Google Scholar 

  71. Wang C, Deng L, Hong M, Akkaraju GR, Inoue J, Chen ZJ (2001) TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412: 346–351

    PubMed  CAS  Google Scholar 

  72. Ghosh S, Karin M (2002) Missing pieces in the NF-kappaB puzzle. Cell 109(Suppl): S81–S96

    PubMed  CAS  Google Scholar 

  73. Hoebe K, Du X, Georgel P, Janssen E, Tabeta K, Kim SO, Goode J, Lin P, Mann N, Mudd S et al (2003) Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 424: 743–748

    Article  PubMed  CAS  Google Scholar 

  74. Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi O, Sugiyama M, Okabe M, Takeda K et al (2003) Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301: 640–643

    Article  PubMed  CAS  Google Scholar 

  75. Sato S, Sugiyama M, Yamamoto M, Watanabe Y, Kawai T, Takeda K, Akira S (2003) Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling. J Immunol 171: 4304–4310

    PubMed  CAS  Google Scholar 

  76. Meylan E, Burns K, Hofmann K, Blancheteau V, Martinon F, Kelliher M, Tschopp J (2004) RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. Nat Immunol 5: 503–507

    Article  PubMed  CAS  Google Scholar 

  77. Kawai T, Adachi O, Ogawa T, Takeda K, Akira S (1999) Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11: 115–122

    Article  PubMed  CAS  Google Scholar 

  78. Yamamoto M, Sato S, Hemmi H, Uematsu S, Hoshino K, Kaisho T, Takeuchi O, Takeda K, Akira S (2003) TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol 4: 1144–1150

    Article  PubMed  CAS  Google Scholar 

  79. Oshiumi H, Sasai M, Shida K, Fujita T, Matsumoto M, Seya T (2003) TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta. J Biol Chem 278: 49751–49762

    Article  PubMed  Google Scholar 

  80. Yamamoto M, Takeda K, Akira S (2004) TIR domain-containing adaptors define the specificity of TLR signaling. Mol Immunol 40: 861–868

    Article  PubMed  CAS  Google Scholar 

  81. Fitzgerald KA, Rowe DC, Barnes BJ, Caffrey DR, Visintin A, Latz E, Monks B, Pitha PM, Golenbock DT (2003) LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. J Exp Med 198: 1043–1055

    Article  PubMed  CAS  Google Scholar 

  82. Servant MJ, Grandvaux N, tenOever BR, Duguay D, Lin R, Hiscott J (2003) Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA. J Biol Chem 278: 9441–9447

    Article  PubMed  CAS  Google Scholar 

  83. Fitzgerald KA, McWhirter SM, Faia KL, Rowe DC, Latz E, Golenbock DT, Coyle AJ, Liao SM, Maniatis T (2003) IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol 4: 491–496

    Article  PubMed  CAS  Google Scholar 

  84. Sharma S, tenOever BR, Grandvaux N, Zhou GP, Lin R, Hiscott J (2003) Triggering the interferon antiviral response through an IKK-related pathway. Science 300: 1148–1151

    PubMed  CAS  Google Scholar 

  85. Kawai T, Sato S, Ishii KJ, Coban C, Hemmi H, Yamamoto M, Terai K, Matsuda M, Inoue J, Uematsu S et al (2004) Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol 5: 1061–1068

    Article  PubMed  CAS  Google Scholar 

  86. Honda K, Ohba Y, Yanai H, Negishi H, Mizutani T, Takaoka A, Taya C, Taniguchi T (2005) Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature 434: 1035–1040

    PubMed  CAS  Google Scholar 

  87. Yu Y, Wang SE, Hayward GS (2005) The KSHV immediate-early transcription factor RTA encodes ubiquitin E3 ligase activity that targets IRF7 for proteosome-mediated degradation. Immunity 22: 59–70

    PubMed  CAS  Google Scholar 

  88. Takaoka A, Yanai H, Kondo S, Duncan G, Negishi H, Mizutani T, Kano S, Honda K, Ohba Y, Mak TW et al (2005) Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. Nature 434: 243–249

    Article  PubMed  CAS  Google Scholar 

  89. Seet BT, Johnston JB, Brunetti CR, Barrett JW, Everett H, Cameron C, Sypula J, Nazarian SH, Lucas A, McFadden G (2003) Poxviruses and immune evasion. Annu Rev Immunol 21: 377–423

    Article  PubMed  CAS  Google Scholar 

  90. Bowie A, Kiss-Toth E, Symons JA, Smith GL, Dower SK, O’Neill LA (2000) A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling. Proc Natl Acad Sci USA 97: 10162–10167

    Article  PubMed  CAS  Google Scholar 

  91. Stack J, Haga IR, Schroder M, Bartlett NW, Maloney G, Reading PC, Fitzgerald KA, Smith GL, Bowie AG (2005) Vaccinia virus protein A46R targets multiple Toll-likeinterleukin-1 receptor adaptors and contributes to virulence. J Exp Med 201: 1007–1018

    Article  PubMed  CAS  Google Scholar 

  92. Harte MT, Haga IR, Maloney G, Gray P, Reading PC, Bartlett NW, Smith GL, Bowie A, O’Neill LA (2003) The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense. J Exp Med 197: 343–351

    Article  PubMed  CAS  Google Scholar 

  93. Leulier F, Marchal C, Miletich I, Limbourg-Bouchon B, Benarous R, Lemaitre B (2003) Directed expression of the HIV-1 accessory protein Vpu in Drosophila fat-body cells inhibits Toll-dependent immune responses. EMBO Rep 4: 976–981

    Article  PubMed  CAS  Google Scholar 

  94. Tato CM, Hunter CA (2002) Host-pathogen interactions: subversion and utilization of the NF-kappa B pathway during infection. Infect Immun 70: 3311–3317

    Article  PubMed  CAS  Google Scholar 

  95. Xiang Y, Condit RC, Vijaysri S, Jacobs B, Williams BR, Silverman RH (2002) Blockade of interferon induction and action by the E3L double-stranded RNA binding proteins of vaccinia virus. J Virol 76: 5251–5259

    PubMed  CAS  Google Scholar 

  96. Shaw ML, Cardenas WB, Zamarin D, Palese P, Basler CF (2005) Nuclear localization of the Nipah virus W protein allows for inhibition of both virus-and toll-like receptor 3-triggered signaling pathways. J Virol 79: 6078–6088

    Article  PubMed  CAS  Google Scholar 

  97. Foy E, Li K, Wang C, Sumpter R Jr, Ikeda M, Lemon SM, Gale M Jr (2003) Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease. Science 300: 1145–1148

    Article  PubMed  CAS  Google Scholar 

  98. Li K, Chen Z, Kato N, Gale M Jr, Lemon SM (2005) Distinct Poly(I-C) and virus-activated signaling pathways leading to interferon-ta production in hepatocytes. J Biol Chem 280: 16739–16747

    PubMed  CAS  Google Scholar 

  99. Foy E, Li K, Sumpter R Jr, Loo YM, Johnson CL, Wang C, Fish PM, Yoneyama M, Fujita T, Lemon SM et al (2005) Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling. Proc Natl Acad Sci USA 102: 2986–2991

    Article  PubMed  CAS  Google Scholar 

  100. Edelmann KH, Richardson-Burns S, Alexopoulou L, Tyler KL, Flavell RA, Oldstone MB (2004) Does Toll-like receptor 3 play a biological role in virus infections? Virology 322: 231–238

    Article  PubMed  CAS  Google Scholar 

  101. Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, Frees K, Watt JL, Schwartz DA (2000) TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 25: 187–191

    PubMed  CAS  Google Scholar 

  102. Lorenz E, Mira JP, Frees KL, Schwartz DA (2002) Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock. Arch Intern Med 162: 1028–1032

    Article  PubMed  CAS  Google Scholar 

  103. Ashkar AA, Bauer S, Mitchell WJ, Vieira J, Rosenthal KL (2003) Local delivery of CpG oligodeoxynucleotides induces rapid changes in the genital mucosa and inhibits replication, but not entry, of herpes simplex virus type 2. J Virol 77: 8948–8956

    PubMed  CAS  Google Scholar 

  104. Yang Y, Huang CT, Huang X, Pardoll DM (2004) Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance. Nat Immunol 5: 508–515

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland

    Sinéad E. Keating & Andrew G. Bowie

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  1. Sinéad E. Keating
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  2. Andrew G. Bowie
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  1. Cytokine Research Group, Department of Biochemistry, Trinity College Dublin, Dublin 2, Ireland

    Luke A.J. O’Neill  & Elizabeth Brint  & 

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© 2006 Birkhäuser Verlag Basel/Switzerland

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Keating, S.E., Bowie, A.G. (2006). Toll-like receptors as key sensors of viral infection. In: O’Neill, L.A., Brint, E. (eds) Toll-like Receptors in Inflammation. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7441-1_8

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