Sleep disturbances in affective disorders

  • Luc Staner
  • Remy Luthringer
  • Olivier Le Bon


Sleep Deprivation Biol Psychiatry NREM Sleep Rapid Tryptophan Depletion Imbalance Theory 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Wu JC, Bunney WE (1990) The biological basis of an antidepressant response to sleep deprivation and relapse: review and hypothesis. Am J Psychiatry 147: 14–21PubMedGoogle Scholar
  2. 2.
    Wehr TA (1991) Sleep-loss as a possible mediator of diverse causes of mania. Br J Psychiatry 159: 576–578PubMedGoogle Scholar
  3. 3.
    Barbini B, Bertelli S, Colombo C, Smeraldi EC (1996) Sleep loss, a possible factor in augmenting manic episode. Psychiatry Res 65: 121–125PubMedCrossRefGoogle Scholar
  4. 4.
    Saper CB, Chou TC, Scammell TE (2001) The sleep switch: hypothalamic control of sleep and wakefulness. Trends Neurosci 24: 726–731PubMedCrossRefGoogle Scholar
  5. 5.
    Pace-Schott EF, Hobson JA (2002) The neurobiology of sleep: genetics, cellular physiology and subcortical networks. Nat Rev Neurosci 3: 591–605PubMedGoogle Scholar
  6. 6.
    Steriade M (2003) The corticothalamic system in sleep. Front Biosci 8: d878–899PubMedGoogle Scholar
  7. 7.
    McGinty D, Szymusiak R (2003) Hypothalamic regulation of sleep and arousal. Front Biosci 8: s1074–s1083PubMedGoogle Scholar
  8. 8.
    Steriade M (1996) Arousal: revisiting the reticular activating system. Science 272: 225–226PubMedGoogle Scholar
  9. 9.
    Lesch DR, Spire JP (1990) Clinical electroencephalography. In: MJ Thorpy (ed): Handbook of Sleep Disorders. Marcel Dekker Inc., New York, 1–31Google Scholar
  10. 10.
    Riemann D, Berger M, Voderholzer U (2001) Sleep and depression — results from psychobiological studies: an overview. Biol Psychol 57: 67–103PubMedCrossRefGoogle Scholar
  11. 11.
    Mendelson WB, Gillin JC, Wyatt RD (1977) Human sleep and ist disorders. Plenum, New YorkGoogle Scholar
  12. 12.
    Armitage R, Cole D, Suppes T, Ozcan ME (2004) Effects of clozapine on sleep in bipolar and schizoaffective disorder. Progr Neuropsychopharm Biol Psychiatry 28: 1065–1070CrossRefGoogle Scholar
  13. 13.
    Reynolds CF III, Kupfer DJ (1987) Sleep research in affective illness: State of the art circa 1987. Sleep 10: 199–215PubMedGoogle Scholar
  14. 14.
    Buysse DJ, Kupfer DJ (1990) Diagnostic and research applications of electroencephalographic sleep studies in depression: conceptual and methodological issues. J Nerv Ment Dis 178: 405–414PubMedGoogle Scholar
  15. 15.
    Kupfer DJ (1976) REM latency: a psychobiological marker for primary depressive disease. Biol Psychiatry 11: 159–174PubMedGoogle Scholar
  16. 16.
    Benca RM, Obermeyer WH, Thisted RA, Gillin JC (1992) Sleep and psychiatric disorders. A meta-analysis. Arch Gen Psychiatry 49: 651–668PubMedGoogle Scholar
  17. 17.
    Insel TR, Gillin JC, Moore A, Mendelson WB, Loewenstein RJ, Murphy DL (1982) The sleep of patients with obsessive-compulsive disorder. Arch Gen Psychiatry 39: 1372–1377PubMedGoogle Scholar
  18. 18.
    Uhde TW, Roy-Byrne P, Gillin JC, Mendelson WB, Boulenger JP, Vittone BJ, Post RM (1984) The sleep of patients with panic disorder. A preliminary report. Psychiatry Res 12: 251–259PubMedCrossRefGoogle Scholar
  19. 19.
    Rosa RR, Bonnet MH, Kramer M (1983) The relationship of sleep and anxiety in anxious subjects. Biol Psychol 16: 119–126PubMedCrossRefGoogle Scholar
  20. 20.
    Reynolds CF 3rd, Soloff PH, Kupfer DJ, Taska LS, Restifo K, Coble PA, McNamara ME (1985) Depression in borderline patients: a prospective EEG sleep study. Psychiatry Res 14: 1–15PubMedCrossRefGoogle Scholar
  21. 21.
    Katz JL, Kuperberg A, Pollack CP, Walsh BT, Zumoff B, Weiner H (1984) Is there a relationship between eating disorder and affective disorder? New evidence from sleep recordings. Am J Psychiatry 141: 753–759PubMedGoogle Scholar
  22. 22.
    Moeller FG, Gillin JC, Irwin M, Golshan S, Kripke DF, Schuckit M (1993) A comparison of sleep EEGs in patients with primary major depression and major depression secondary to alcoholism. J Affect Disord 27: 39–42PubMedCrossRefGoogle Scholar
  23. 23.
    Thase ME, Kupfer DJ, Ulrich RF (1986) Electroencephalographic sleep in psychotic depression: a valid subtype. Arch Gen Psychiatry 43: 886–893PubMedGoogle Scholar
  24. 24.
    Parker G, Hadzi-Pavlovic D, Hickie I, Boyce P, Mitchell P, Wilhelm K, Brodaty H (1991) Distinguishing psychotic and non-psychotic melancholia. J Affective Disord 22: 135–148CrossRefGoogle Scholar
  25. 25.
    Akiskal HS, Maser JD, Zeller PJ, Endicott J, Coryell W, Keller M, Warshaw M, Clayton P, Goodwin F (1995) Switching from unipolar to bipolar II. Arch Gen Psychiatry 52: 114–123PubMedGoogle Scholar
  26. 26.
    Hubain P, Van Veeren C, Staner L, Mendlewicz J, Linkowski P (1996) Neuroendocrine and sleep variables in major depressed inpatients: role of severity. Psychiatry Res 63:83–92PubMedCrossRefGoogle Scholar
  27. 27.
    Fossion P, Staner L, Dramaix M, Kempenaers C, Kerkhofs M, Hubain P, Verbanck P, Mendlewicz J, Linkowski P (1998) Does sleep EEG data distinguish between UP, BPI or BPII major depressions? An age and gender controlled study. J Affect Disord 49: 181–187PubMedCrossRefGoogle Scholar
  28. 28.
    Stefos G, Staner L, Kerkhofs M, Hubain P, Mendlewicz J, Linkowski P (1998) Shortened REM latency as a psychobiologic marker for psychotic depression? An age, gender and polarity controlled study. Biol Psychiatry 44: 1314–1320PubMedCrossRefGoogle Scholar
  29. 29.
    Thase ME, Himmelhoch JM, Mallinger AG, Jarrett DB, Kupfer DJ (1989) Sleep EEG and DST findings in anergic bipolar depression. Am J Psychiatry 146: 329–333PubMedGoogle Scholar
  30. 30.
    Riemann D, Voderholzer U, Berger M (2002) Sleep and sleep-wake manipulations in bipolar depression. Neuropsychobiology 45,Suppl 1: 7–12PubMedCrossRefGoogle Scholar
  31. 31.
    Kerkhofs M, Linkowski P, Lucas F, Mendlewicz J (1991) Twenty-four-hour patterns of sleep in depression. Sleep 14: 501–506PubMedGoogle Scholar
  32. 32.
    Hudson JI, Lipinski JF, Frankenburg FR, Grochocinski VJ, Kupfer DJ (1988) Electroencephalographic sleep in mania. Arch Gen Psychiatry 45: 267–273PubMedGoogle Scholar
  33. 33.
    Hudson JI, Lipinski JF, Keck PE Jr, Aizley HG, Lukas SE, Rothschild AJ, Waternaux CM, Kupfer DJ (1992) Polysomnographic characteristics of young manic patients. Arch Gen Psychiatry 49: 378–383PubMedGoogle Scholar
  34. 34.
    Linkowski P, Kerkhofs M, Van Onderbergen A, Hubain P, Copinschi G, L’Hermite-Baleriaux M, Leclercq R, Brasseur M, Mendlewicz J, Van Cauter E (1994) The 24-hour profiles of cortisol, prolactin, and growth hormone secretion in mania. Arch Gen Psychiatry 51: 616–624PubMedGoogle Scholar
  35. 35.
    Gann H, Riemann D, Hohagen F, Strauss LG, Dressing H, Muller WE, Berger M (1993) 48-hour rapid cycling: Results of psychopathometric, polysomnographic, PET imaging and neuroendocrine longitudinal investigation in a single case. J Affect Disord 28: 133–140PubMedCrossRefGoogle Scholar
  36. 36.
    Riemann D, Berger M (1989) EEG sleep in depression and in remission and the REM response to the cholinergic agonist RS-86. Neuropsychopharmacology 2: 145–152PubMedCrossRefGoogle Scholar
  37. 37.
    Thase ME, Fasiczka AL, Berman SR, Simons AD, Reynolds CF 3rd (1998) Electroencephalographic sleep profiles before and after cognitive behaviour therapy of depression. Arch Gen Psychiatry 55: 138–144PubMedCrossRefGoogle Scholar
  38. 38.
    Jindal RD, Thase ME, Fasiczka AL, Friedman ES, Buysse DJ, Frank E, Kupfer DJ (2002) Electroencephalographic profiles in single episode and recurrent unipolar forms of major depression. Biol Psychiatry 51: 230–236PubMedCrossRefGoogle Scholar
  39. 39.
    Rush AJ, Erman MK, Giles DE, Schlesser MA, Carpenter G, Vasavada N, Roffwarg HP (1986) Polysomnographic findings in recently drug-free and clinically remitted depressed patients. Arch Gen Psychiatry 43: 878–884PubMedGoogle Scholar
  40. 40.
    Steiger A, von Bardeleben U, Herth T, Holsboer F (1989) Sleep EEG and nocturnal secretion of cortisol and growth hormone in male patients with endogenous depression before treatment and after recovery. J Affect Disord 16: 189–195PubMedCrossRefGoogle Scholar
  41. 41.
    Buysse DJ, Kupfer DJ, Frank E, Monk TH, Ritenour A (1992) Electroencephalographic sleep studies in depressed outpatients treated with interpersonal psychotherapy. II Longitudinal studies at baseline and recovery. Psychiatry Res 40: 27–40CrossRefGoogle Scholar
  42. 42.
    Hatzinger M, Hemmeter UM, Brand S, Ising M, Holsboer-Trachsler E (2004) Electroencephalographic sleep EEG profiles in treatment course and long-term outcome of major depression: association with DEX/CRH-test response. J Psychiatr Res 38: 453–465PubMedCrossRefGoogle Scholar
  43. 43.
    Sitaram N, Nurnberger JI, Gershon ES (1980) Faster cholinergic REM sleep induction in euthymic patients with primary affective illness. Science 20: 200–201Google Scholar
  44. 44.
    Sitaram N, Nurnberger JI, Gershon ES, Gillin JC (1982) Cholinergic regulation of mood and REM sleep: potential model and marker of vulnerability to affective disorder. Am J Psychiatry 139: 571–576PubMedGoogle Scholar
  45. 45.
    Giles DE, Jarrett RB, Roffwarg HP, Rush AJ (1987) Reduced rapid eye movement latency: a predictor of reccurence in depression. Neuropsychopharmacology 1: 33–49PubMedCrossRefGoogle Scholar
  46. 46.
    Mendlewicz J, Sevy S, de Martelaer V (1989) REM sleep latency and morbidity risk of affective disorders in depressive illness. Neuropsychobiology 22: 14–17PubMedCrossRefGoogle Scholar
  47. 47.
    Giles DE, Kupfer DJ, Rush JA, Roffwarg HP (1998) Controlled comparison of electrophysiological sleep in families of probands with unipolar depression. Am J Psychiatry 155: 192–199PubMedGoogle Scholar
  48. 48.
    Schreiber W, Lauer CJ, Krumrey K, Holsboer F, Krieg JC (1992) REM sleep desinhibition after cholinergic challenge in subjects at high risk for psychiatric disorder. Biol Psychiatry 33: 79–90CrossRefGoogle Scholar
  49. 49.
    Lauer CJ, Schreiber W, Holsboer F, Krieg JC (1995) In quest of identifying vulnerability markers for psychiatric disorders by all-night polysomnography. Arch Gen Psychiatry 52: 145–153PubMedGoogle Scholar
  50. 50.
    Modell S, Huber J, Holsboer F, Lauer CJ (2003) The Munich vulnerability study on affective disorders: risk factors for unipolarity versus bipolarity. J Affective Disord 74: 173–184CrossRefGoogle Scholar
  51. 51.
    Modell S, Ising M, Holsboer F, Lauer CJ (2002) The Munich vulnerability study on affective disorders: stability of polysomnographic findings over time. Biol Psychiatry 52: 430–437PubMedCrossRefGoogle Scholar
  52. 52.
    Lauer CJ, Modell S, Schreiber W, Krieg JC, Holsboer F (2004) Prediction of the development of a first major depressive episode with a rapid eye movement sleep induction test using the cholinergic agonist RS 86. J Clin Psychopharmacol 24: 356–357PubMedCrossRefGoogle Scholar
  53. 53.
    Borbely AA (1982) A two process model for sleep regulation. Hum Neurobiol 1: 195–204PubMedGoogle Scholar
  54. 54.
    Edgar DM, Dement WC, Fuller CA (1993) Effect of SCN lesions on sleep in squirrel monkeys: evidence for opponent processes in sleep-wake regulation. J Neurosci 13: 1065–1079PubMedGoogle Scholar
  55. 55.
    Saper CB, Sherin JE, Elmquist JK (1997) Role of the ventrolateral preoptic area in sleep induction. In: O Hayaishi, S Inoue (eds): Sleep and Sleep Disorders: From Molecule to Behaviour. Academic Press, New YorkGoogle Scholar
  56. 56.
    Hobson JA, Pace-Schott EF, Stickgold R (2003) Dreaming and the brain: Toward a cognitive neuroscience of conscious states. In: EF Pace Schott, M Solms, M Blagrove, S Harnad (eds): Sleep and Dreaming. Cambridge University Press, Cambridge, 1–50Google Scholar
  57. 57.
    Beuckmann CT, Yanagisawa M (2002) Orexins: from neuropeptides to energy homeostasis and sleep/wake regulation. J Mol Med 80: 329–342PubMedCrossRefGoogle Scholar
  58. 58.
    Taheri S, Zeitzer JM, Mignot E (2002) The role of hypocretins (orexins) in sleep regulation nad narcolepsy. Annu Rev Neurosci 25: 283–313PubMedCrossRefGoogle Scholar
  59. 59.
    Maquet P (2000) Functional neuroimaging of normal human sleep by positron emission tomography. J Sleep Res 9: 207–231PubMedCrossRefGoogle Scholar
  60. 60.
    Ho AP, Gillin JC, Buchsbaum MS, Wu JC, Abel L, Bunney WE Jr (1996) Brain glucose metabolism during non-rapid eye movement sleep in major depression. A positron emission tomography study. Arch Gen Psychiatry 53: 645–652PubMedGoogle Scholar
  61. 61.
    Germain A, Nofzinger EA, Kupfer DJ, Buysse DJ (2004) Neurobiology of non-REM sleep in depression: further evidence for hypofrontality and thalamic dysregulation. Am J Psychiatry 161: 1856–1863PubMedCrossRefGoogle Scholar
  62. 62.
    Nofzinger EA, Price JC, Meltzer CC, Buysse DJ, Villemagne VL, Miewald JM, Sembrat RC, Steppe DA, Kupfer DJ (2000) Toward a neurobiology of dysfunctional arousal in depression: the relationship between beta EEG power and regional cerebral glucose metabolism during NREM sleep. Psychiatry Res Neuroimaging 98: 71–91CrossRefGoogle Scholar
  63. 63.
    Salomon RM, Ripley B, Kennedy JS, Johnson B, Schmidt D, Zeitzer JM, Nishino S, Mignot E (2003) Diurnal variation of cerebrospinal fluid hypocretin-1 (Orexin-A) levels in control and depressed subjects. Biol Psychiatry 54: 96–104PubMedCrossRefGoogle Scholar
  64. 64.
    Van Praag HM (2004) Can stress cause depression? Progr Neuropsychopharmacol Biol Psychiatry 28: 891–907CrossRefGoogle Scholar
  65. 65.
    Koob GF (1999) Corticotropin-releasing factor, norepinephrine and stress. Biol Psychiatry 46: 1167–1180PubMedCrossRefGoogle Scholar
  66. 66.
    Mc Ewen BS (2000) Allostasis and allostatic load: implications for neuropsychopharmacology. Neuropsychopharmacology 22: 108–124CrossRefGoogle Scholar
  67. 67.
    Gold PW, Chroussos GP (2002) Organisation of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states. Mol Psychiatry 7: 254–275PubMedCrossRefGoogle Scholar
  68. 68.
    Holsboer F (2000) The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 23: 477–501PubMedCrossRefGoogle Scholar
  69. 69.
    Müller MB, Wurst W (2004) Getting closer to affective disorders: the role of the CRH receptor system. Trends Mol Med 10: 409–415PubMedCrossRefGoogle Scholar
  70. 70.
    Arango V, Underwood MD, Mann JJ (1996) Fewer pigmented locus coeruleus neurons in suicide victims: Preliminary results. Biol Psychiatry 39: 112–120PubMedCrossRefGoogle Scholar
  71. 71.
    Bissette G, Klimek V, Pan J, Stockmeier C, Ordway G (2003) Elevated concentrations of CRF in the locus coeruleus of depressed subjects. Neuropsychopharmacology 28:1328–1335PubMedCrossRefGoogle Scholar
  72. 72.
    Klimek V, Stockmeier C, Overholser J, Meltzer HY, Kalka S, Dilley G, Ordway GA (1997) Reduced levels of norepinephrine transporters in the locus coeruleus in major depression. J Neurosci 17: 8451–8458PubMedGoogle Scholar
  73. 73.
    Baumann B, Danos P, Diekmann S, Krell D, Bielau H, Geretsegger C, Wurthmann C, Bernstein HG, Bogerts B (1999) Tyrosine hydroxylase immunorecativity in the locus coeruleus is reduced in depressed non-suicidal patients but normal in depressed suicide patients. Eur Arch Psychiatry Clin Neurosci 249: 212–219PubMedCrossRefGoogle Scholar
  74. 74.
    Agelink MW, Klimke A, Cordes J, Sanner D, Kavuk I, Malessa R, Klieser E, Baumann B (2004) A functional-structural model to understand cardiac autonomic nervous system (ANS) dysregulation in affective illness and to elucidate the ANS effects of antidepressive treatment. Eur J Med Res 9: 37–50PubMedGoogle Scholar
  75. 75.
    Gorman JM, Sloan RP (2000) Heart rate variability in depressive and anxiety disorders. Am Heart J 140(4 Suppl): 77–83PubMedCrossRefGoogle Scholar
  76. 76.
    Hubain PP, Staner L, Dramaix M, Kerkhofs M, Papadimitriou G, Mendlewicz J, Linkowski P (1998) The dexamethasone suppression test and sleep electroencephalogram in major depressed inpatients: a multivariate analysis. Biol Psychiatry 43: 220–229PubMedCrossRefGoogle Scholar
  77. 77.
    Staner L, Duval F, Haba J, Mokrani MC, Macher JP (2003) Disturbances in hypothalamo pituitary adrenal and thyroid axis identify different sleep EEG patterns in major depressed patients. J Psychiatry Res 37: 1–8CrossRefGoogle Scholar
  78. 78.
    Wong ML, Kling MA, Munson PJ, Listwak S, Licinio J, Prolo P, Karp B, McCutcheon IE, Geracioti TD Jr, DeBellis MD et al. (2000) Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: relation to hypercortisolism and corticotrophin-releasing-hormone. Proc Natl Acad Sci 97: 325–330PubMedCrossRefGoogle Scholar
  79. 79.
    Le Bon O, Staner L, Hoffmann G, Dramaix M, San Sebastian I, Murphy JR, Kentos M, Pelc I, Linkowski P (2001) The first night effect may last more than one night. J Psychiatry Res 35: 165–172CrossRefGoogle Scholar
  80. 80.
    Van Reeth O, Weibel L, Spiegel K, Leproult R, Dugovic C, Maccari S (2000) Interactions between stress and sleep: from basic research to clinical situations. Sleep Med Rev 4: 201–219CrossRefGoogle Scholar
  81. 81.
    Ruggiero DA, Underwood MD, Rice PM, Mann JJ, Arango V (1999) Corticotropic-releasing hormone and serotonin interact in the human brainstem: behavioural implications. Neuroscience 91: 1343–1354PubMedCrossRefGoogle Scholar
  82. 82.
    Kirby LG, Rice KC, Valentino RJ (2000) Effects of corticotropin-releasing factor on neuronal activity in the serotoninergic dorsal raphe nucleus. Neuropsychopharmacology 22: 148–162PubMedCrossRefGoogle Scholar
  83. 83.
    Lopez JF, Chalmers DT, Little KY, Watson SJ (1998) Regulation of serotonin 1a, glucocorticoid and mineralocorticoid receptor in rat and human hippocampus: implications for the neurobiology of depression. Biol Psychiatry 43: 547–573PubMedCrossRefGoogle Scholar
  84. 84.
    Wissink S, Meijer O, Pearce D, van Der Burg B, van Der Saag PT (2000) Regulation of the rat serotonin-1A receptor gene by corticosteroids. J Biol Chem 275: 1321–1326PubMedCrossRefGoogle Scholar
  85. 85.
    Monti JM, Monti D (2000) Role of the dorsal raphe nucleus serotonin 5-HT1A receptor in the regulation of sleep. Life Sci 21: 1999–2012CrossRefGoogle Scholar
  86. 86.
    Staner L, Linker T, Toussaint M, Danjou P, Roegel JC, Luthringer R, Le Fur G, Macher JP (2001) Effects of the selective activation of 5-HT3 receptors on sleep: a ploysomnographic study in healthy volunteers. Eur Neuropsychopharmacol 11: 301–305PubMedCrossRefGoogle Scholar
  87. 87.
    Chou TC, Bjorkum AA, Gaus SE, Lu J, Scammell TE, Saper CB (2002) Afferents to the ventrolateral preoptic nucleus. J Neurosci 22: 977–990PubMedGoogle Scholar
  88. 88.
    Basheer R, Strecker RE, Thakkar MM, Mc Carley RW (2004)Adenosine and sleep-wake regulation. Progr Neurobiol 73: 379–396PubMedCrossRefGoogle Scholar
  89. 89.
    Chamberlin NL, Arrigoni E, Chou TC, Scammell TE, Greene RW, Saper CB (2003) Effects of adenosine on GABAergic synaptic inputs to identified ventrolateral preoptic neurons. Neuroscience 119: 913–918PubMedCrossRefGoogle Scholar
  90. 90.
    Morairtry S, Rainnie D, Mc Carley R, Greene R (2004) Dishinbition of ventrolateral preoptic area sleep-active neurons by adenosine: a new mechanism for sleep promotion. Neuroscience 123: 451–457CrossRefGoogle Scholar
  91. 91.
    Borbely AA, Wirz-Justice A (1982) Sleep, sleep deprivation and depression. A hypothesis derived from a model of sleep regulation. Hum Neurobiol 1: 205–210PubMedGoogle Scholar
  92. 92.
    Borbely AA, Tobler I, Loepfe M, Kupfer DJ, Ulrich RF, Grochocinski V, Doman J, Matthews G (1984) All-night spectral analysis of the sleep EEG in untreated depressives and normal controls. Psychiatry Res 12: 27–33PubMedCrossRefGoogle Scholar
  93. 93.
    Kupfer DJ, Ulrich RF, Coble PA, Jarrett DB, Grochocinski V, Doman J, Matthews G, Borbely AA (1984) Applications of an automated REM and slow wave sleep analysis. II. Testing the assumptions of the two-process model of sleep regulation in normal and depressed subjects. Psychiatry Res 13: 335–343PubMedCrossRefGoogle Scholar
  94. 94.
    Kupfer DJ, Frank E, Ehlers CL (1989) EEG sleep in young depressives: first and second night effect. Biol Psychiatry 25: 87–97PubMedCrossRefGoogle Scholar
  95. 95.
    Kupfer DJ, Frank E, Mc Eachran AB, Grochocinski VJ (1990) Delta sleep ratio: a biological correlate of early recurrence in unipolar affective disorder. Arch Gen Psychiatry 47: 1100–1105PubMedGoogle Scholar
  96. 96.
    Armitage R, Hoffmann RF, Trivedi M, Rush JA (2000) Slow wave activity in NREM sleep: sex and age effects in depressed outpatients and healthy controls. Psychiatry Res 95: 201–213PubMedCrossRefGoogle Scholar
  97. 97.
    Armitage R, Emslie GJ, Hoffmann RF, Rintelmann J, Rush AJ (2001) Delta sleep EEG in depressed adolescent females and healthy controls. J Affect Disord 63: 139–148PubMedCrossRefGoogle Scholar
  98. 98.
    Staner L, Cornette F, Maurice D, Viardot G, Le Bon O, Haba J, Staner C, Luthringer R, Muzet A, Macher JP (2003) Sleep microstructure around sleep onset differentiates major depressive insomnia from primary insomnia. J Sleep Res 12: 319–330PubMedGoogle Scholar
  99. 99.
    Mendelson WB, Sack DA, James SP, Martin JV, Wagner R, Garnett D, Milton J, Wehr TA (1987) Frequency analysis of sleep EEG in depression. Psychiatry Res 21: 89–94PubMedCrossRefGoogle Scholar
  100. 100.
    Armitage R, Calhoun JS, Rush AJ, Roffwarg HP (1992) Comparison of the delta EEG in the first and second non-REM periods in depressed adults and normal controls. Psychiatry Res 41: 65–72PubMedCrossRefGoogle Scholar
  101. 101.
    Kupfer DJ, Reynolds CF III, Ehlers CL (1989) Comparison of EEG sleep measures among depressive subtypes and controls in older individuals. Psychiatry Res 27: 13–21PubMedCrossRefGoogle Scholar
  102. 102.
    Perlis ML, Kehr EL, Smith MT, Andrews PJ, Orff H, Giles DE (2001) Temporal and stagewise distribution of high frequency activity in patients with primary and secondary insomnia and in good sleeper control. J Sleep Res 10: 93–104PubMedCrossRefGoogle Scholar
  103. 103.
    Porkka-Heiskanen T, Strecker RE, Thakkar M, Bjorkum AA, Greene RW, McCarley RW (1997) Adenosine: a mediator of the sleep-inducing effects of prolonged wakefulness. Science 276: 1265–1268PubMedCrossRefGoogle Scholar
  104. 104.
    Ribeiro JA, Sebastiao AM, de Mendonça A (2003) Adenosine receptors in the nervous system: pathophysiological implications. Progr Neurobiol 68: 377–392CrossRefGoogle Scholar
  105. 105.
    Berk M, Plein H, Ferreira D, Jersky B (2001) Blunted adenosine A2a receptor function in platelets in patients with major depression. Eur Neuropsychopharmacol 11: 183–186PubMedCrossRefGoogle Scholar
  106. 106.
    Elgun S, Keskinege A, Kumbasar H (1999) Dipeptidyl peptidase IV and adenosine deaminase activity. Decrease in depression. Psychoneuroendocrinology 24: 823–832PubMedCrossRefGoogle Scholar
  107. 107.
    McCarley RW, Hobson JA (1975) Neuronal excitability modulation over the sleep cycle: a structural and mathematical model. Science 189: 58–60PubMedGoogle Scholar
  108. 108.
    Mc Carley RW (1982) REM sleep and depression: common neurobiological control mechanisms. Am J Psychiatry 139: 565–570Google Scholar
  109. 109.
    Nofzinger EA, Buysse DJ, Germain A, Carter C, Luna B, Price JC, Meltzer CC, Miewald JM, Reynolds CF 3rd, Kupfer DJ (2004) Increased activation of anterior paralimbic and executive cortex from waking to rapid eye movement sleep in depression. Arch Gen Psychiatry 61: 695–702PubMedCrossRefGoogle Scholar
  110. 110.
    Gillin JC, Sitaram N, Wehr T, Duncan WC, Post RM, Murphy DL, Mendelson UB, Wyatt RJ, Bunney WE (1984) Sleep and affective illness. In: RM Post, JC Ballenger (eds): Neurobiology of Mood Disorder. Williams & Wilkins, Baltimore, London, 157–188Google Scholar
  111. 111.
    Moore P, Gillin C, Bhatti T, DeModena A, Seifritz E, Clark C, Stahl S, Rapaport M, Kelsoe J (1998) Rapid tryptophan depletion, sleep electroencephalogram, and mood in men with remitted depression on serotonin reuptake inhibitors. Arch Gen Psychiatry 55: 534–539PubMedCrossRefGoogle Scholar
  112. 112.
    Evans L, Golshan S, Kelsoe J, Rapaport M, Resovsky K, Sutton L, Gillin JC (2002) Effects of rapid tryptophan depletion on sleep electroencephalogram and mood in subjects with partially remitted depression on bupropion. Neuropsychopharmacology 27: 1016–1026PubMedCrossRefGoogle Scholar
  113. 113.
    Landolt HP, Kelsoe JR, Rapaport MH, Gillin JC (2003) Rapid tryptophan depletion reverses phenelzine-induced suppression of REM sleep. J Sleep Res 12: 13–18PubMedCrossRefGoogle Scholar
  114. 114.
    Haynes PL, McQuaid JR, Kelsoe J, Rapaport M, Gillin JC (2004) Affective state and EEG sleep profile in response to rapid tryptophan depletion in recently recovered nonmedicated depressed individuals. J Affect Disord 83: 253–262PubMedCrossRefGoogle Scholar
  115. 115.
    Bhatti T, Gillin JC, Seifritz E, Moore P, Clark C, Golshan S, Stahl S, Rapaport M, Kelsoe J (1998) Effects of a tryptophan-free amino acid drink challenge on normal human sleep electroencephalogram and sleep. Biol Psychiatry 43: 52–59PubMedCrossRefGoogle Scholar
  116. 116.
    Voderholzer U, Hornyak M, Thiel B, Huwig-Poppe C, Kiemen A, Konig A, Backhaus J, Riemann D, Berger M, Hohagen F (1998) Impact of experimentally induced serotonin deficiency by tryptophan depletion on sleep EEG in healthy subjects. Neuropsychopharmacology 18: 112–124PubMedCrossRefGoogle Scholar
  117. 117.
    Janowsky DS, El Youssef MK, Davis JM, Sekerke HJ (1972) A cholinergic-adrenergic hypothesis of mania and depression. Lancet 2: 632–635PubMedCrossRefGoogle Scholar
  118. 118.
    Nestler EJ, Alreja M, Aghajanian GK (1999) Molecular control of locus coeruleus neurotransmission. Biol Psychiatry 46: 1131–1139PubMedCrossRefGoogle Scholar
  119. 119.
    Volkers AC, Tulen JH, van den Broek WW, Bruyn JA, Passchier J, Pepplinkhuizen L (2004) Effects of imipramine, fluvoxamine and depressive mood on autonomic cardiac functioning in major depressive disorder. Pharmacopsychiatry 37: 18–25PubMedCrossRefGoogle Scholar
  120. 120.
    Murck H, Held K, Ziegenbein M, Kunzel H, Holsboer F, Steiger A (2004) Intravenous administration of the neuropeptide galanin has fast antidepressant efficacy and affects the sleep EEG. Psychoneuroendocrinology 29: 1205–1211PubMedCrossRefGoogle Scholar
  121. 121.
    Zobel AW, Nickel T, Kunzel HE, Ackl N, Sonntag A, Ising M, Holsboer F (2000) Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated. J Psychiary Res 34: 171–181CrossRefGoogle Scholar
  122. 122.
    Held K, Kunzel H, Ising M, Schmid DA, Zobel A, Murck H, Holsboer F, Steiger A (2004) Treatment with the CRH1 receptor antagonist R121919 improves sleep-EEG in patients with depression. J Psychiatry Res 38: 129–136CrossRefGoogle Scholar
  123. 123.
    Kaster MP, Rosa AO, Rosso MM, Goulart EC, Santos AR, Rodrigues AL (2004) Adenosine administration produces an antidepressant-like effect in mice: evidence for the involvement of A1 and A2A receptors. Neurosci Lett 355: 21–24PubMedCrossRefGoogle Scholar
  124. 124.
    El Yacoubi M, Ledent C, Parmentier M, Bertorelli R, Ongini E, Costentin J, Vaugeois JM (2001) Adenosine A2A receptor antagonists are potential antidepressants: evidence based on pharmacology and A2A receptor knockout mice. Br J Pharmacol 134: 68–77PubMedCrossRefGoogle Scholar
  125. 125.
    Phillis JW, Wu PH (1982) The effect of various centrally active drugs on adenosine uptake by the central nervous system. Comp Biochem Physiol 72C: 179–187Google Scholar
  126. 126.
    Phillis JW (1984) Potentiation of the action of adenosine on cerebral cortical neurones by the tricyclic antidepressants. Br J Pharmacol 83: 567–575PubMedGoogle Scholar
  127. 127.
    Zahorodna A, Bijak M, Hess G (2002) Differential effects of repeated imipramine on hippocampal responsiveness to adenosine and serotonin. Eur Neuropsychopharmacol 12: 355–360PubMedCrossRefGoogle Scholar
  128. 128.
    Berger M, van Calker D, Riemann D (2003) Sleep and manipulations of the sleep-wake rhythm in depression. Acta Psychiatr Scand (Suppl 418): 83–91CrossRefGoogle Scholar
  129. 129.
    Staner L, Luthringer R, Macher JP (1999) Effects of antidepressant drugs on sleep EEG in patients with major depression. Mechanisms and therapeutic implications. CNS Drugs 11: 49–60CrossRefGoogle Scholar
  130. 130.
    Heiligenstein JH, Faries DE, Rush AJ, Andersen JS, Pande AC, Roffwarg HP, Dunner D, Gillin JC, James SP, Lahmeyer H et al. (1994) Latency to rapid eye movement sleep as a predictor of treatment response to fluoxetine and placebo in nonpsychotic depressed outpatients. Psychiatry Res 52: 327–339PubMedCrossRefGoogle Scholar
  131. 131.
    Thase ME, Simons AD, Reynolds CF III (1996) Abnormal electroencephalographic sleep profiles in major depression. Association with response to cognitive behavior therapy. Arch Gen Psychiatry 53: 99–108PubMedGoogle Scholar
  132. 132.
    Buysse DJ, Tu XM, Cherry CR, Begley AE, Kowalski J, Kupfer DJ, Frank E (1999) Pretreatment REM sleep and subjective sleep quality distinguish depressed psychotherapy remitters and nonremitters. Biol Psychiatry 45: 205–213PubMedCrossRefGoogle Scholar
  133. 133.
    Ott GE, Rao U, Nuccio I, Lin KM, Poland RE (2002) Effect of bupropion-SR on REM sleep: relationship to antidepressant response. Psychopharmacology 165: 29–36PubMedCrossRefGoogle Scholar
  134. 134.
    Murck H, Nickel T, Kunzel H, Antonijevic IA, Schill J, Zobel A, Steiger A, Sonntag A, Holsboer F (2003) State markers of depression in sleep EEG: dependency on drug and gender in patients treated with tianeptine or paroxetine. Neuropsychopharmacology 28: 348–358PubMedCrossRefGoogle Scholar
  135. 135.
    Staner L, Mendlewicz J (1994) Effect of a single dose of tianeptine in healthy volunteer on sleep electrophysiological parameters. Eur Psychiatry 9(Suppl 1):141Google Scholar
  136. 136.
    Nofzinger EA, Reynolds CF 3rd, Thase ME, Frank E, Jennings JR, Fasiczka AL, Sullivan LR, Kupfer DJ (1995) REM sleep enhancement by bupropion in depressed man. Am J Psychiatry 152: 274–276PubMedGoogle Scholar
  137. 137.
    Coble PA, Kupfer DJ, Spiker DG, Neil JF, McPartland RJ (1979) EEG sleep in primary depression: a longitudinal placebo study. J Affect Disord 1: 131–138PubMedCrossRefGoogle Scholar
  138. 138.
    Akiskal HS, Rosenthal TL, Haykal RF, Lemmi H, Rosenthal RH, Scott-Strauss A (1980) Characterological depressions: clinical and sleep EEG findings separating subaffective dysthymias from character spectrum disorders. Arch Gen Psychiatry 37: 777–783PubMedGoogle Scholar
  139. 139.
    Svendson K, Christensen PG (1981) Duration of REM latency as predictor of effect of antidepressant therapy. Acta Psychiatr Scand 64: 238–243Google Scholar
  140. 140.
    Rush AJ, Erman MK, Schlesser MA, Roffwarg HP, Vasavada N, Khatami M, Fairchild C, Giles DE (1985) Alprazolam vs amitriptyline in depressions with reduced REM latencies. Arch Gen Psychiatry 42: 1154–1159PubMedGoogle Scholar
  141. 141.
    Rush AJ, Giles DE, Jarrett RB, Feldman-Koffler F, Debus JR, Weissenburger J, Orsulak PJ, Roffwarg HP (1989) Reduced REM latency predicts response to tricyclic medication in depressed outpatients. Biol Psychiatry 26: 61–72PubMedCrossRefGoogle Scholar
  142. 142.
    Kupfer DJ, Spiker DG, Coble PA, Neil JF, Ulrich R, Shaw DH (1981) Sleep and treatment prediction in endogenous depression. Am J Psychiatry 138: 429–434PubMedGoogle Scholar
  143. 143.
    Kupfer DJ, Foster FG, Reich L, Thompson SK, Weiss B (1976) EEG sleep changes as predictors in depression. Am J Psychiatry 133: 622–626PubMedGoogle Scholar
  144. 144.
    Gillin JC, Wyatt RJ, Fram D, Snyder F (1978) The relationship between changes in REM sleep and clinical improvement in depressed patients treated with amitriptyline. Psychopharmacology 59: 267–272PubMedCrossRefGoogle Scholar
  145. 145.
    Hochli D, Riemann D, Zulley J, Berger M (1986) Initial REM sleep suppression by clomipramine: a prognostic tool for treatment response in patients with major depressive disorder. Biol Psychiatry 21: 1217–1220PubMedCrossRefGoogle Scholar
  146. 146.
    Mendlewicz J, Kempenaers C, De Martelaer V (1991) Sleep EEG and amitriptyline treatment in depressed inpatients. Biol Psychiatry 30: 691–702PubMedCrossRefGoogle Scholar
  147. 147.
    Van Bemmel AL, Beersma DGM, Van Den Hoofdakker RH (1993) Changes in EEG power density of NREM sleep in depressed patients during treatment with citalopram. J Sleep Res 2: 156–162PubMedGoogle Scholar
  148. 148.
    Staner L, Kerkhofs M, Detroux D, Leyman S, Linkowski P, Mendlewicz J (1995) Acute, subchronic, and withdrawal sleep EEG changes during treatment with paroxetine and amitriptyline: a double-blind randomized trial in major depression. Sleep 18: 470–477PubMedGoogle Scholar
  149. 149.
    Berger M, Riemann D (1993) REM sleep in depression-an overview. J Sleep Res 2: 211–223PubMedCrossRefGoogle Scholar
  150. 150.
    Gillin JC, Buchsbaum M, Wu J, Clark C, Bunney W Jr (2001) Sleep deprivation as a model experimental antidepressant treatment: findings from functional brain imaging. Depression Anxiety 14: 37–49CrossRefGoogle Scholar
  151. 151.
    Mallick BN, Siegel JM, Fahringer H (1990) Changes in pontine unit activity with REM sleep deprivation. Brain Res 515: 94–98PubMedCrossRefGoogle Scholar
  152. 152.
    Payne JL, Quiroz JA, Zarate CA Jr, Manji HK (2002) Timing is everything: does the robust upregulation of noradrenergically regulated plasticity genes underlie the rapid antidepressant effects of sleep deprivation? Biol Psychiatry 52: 921–926PubMedCrossRefGoogle Scholar
  153. 153.
    Vgontzas AN, Mastorakos G, Bixler EO, Kales A, Gold PW, Chrousos GP (1999) Sleep deprivation effects on the activity of the hypothalamic-pituitary-adrenal and growth axes: potential clinical implications. Clin Endocrinol 51: 205–215CrossRefGoogle Scholar
  154. 154.
    Kupfer DJ, Ehlers CL (1989) Two roads to rapid eye movement latency. Arch Gen Psychiatry 46: 945–948PubMedGoogle Scholar
  155. 155.
    Wirz-Justice A, Van den Hoofdakker RH (1999) Sleep deprivation in depression: what do we know, where do we go? Biol Psychiatry 46: 445–453PubMedCrossRefGoogle Scholar
  156. 156.
    Biber K, Fiebich BL, Gebicke-Harter P, van Calker D (1999) Carbamazepine-induced upregulation of adenosine A1-receptors in astrocyte cultures affects coupling to the phosphoinositol signaling pathway. Neuropsychopharmacology 20: 271–278PubMedCrossRefGoogle Scholar
  157. 157.
    Adrien J (2002) Neurobiological bases for the relation between sleep and depression. Sleep Med Rev 6: 341–351PubMedGoogle Scholar
  158. 158.
    Seifritz E (2001) Contribution of sleep physiology to depressive pathophysiology. Neuropsychopharmacology 25: S85–S88PubMedCrossRefGoogle Scholar
  159. 159.
    Le Bon O, Staner L, Murphy JR, Hoffmann G, Pull CH, Pelc I (1997) Critical analysis of the theories advanced to explain short REM sleep latencies and other sleep anomalies in several psychiatric conditions. J Psychiatry Res 31: 433–450CrossRefGoogle Scholar

Copyright information

© Birkhäuser Verlag/Switzerland 2006

Authors and Affiliations

  • Luc Staner
    • 1
  • Remy Luthringer
    • 2
  • Olivier Le Bon
    • 3
  1. 1.Unité d’Exploration des Rythmes Veille-SommeilFrance
  2. 2.FORENAP PharmaCentre Hospitalier de RouffachFrance
  3. 3.Department of Psychiatry, Hôpital Universitaire BrugmannFree University of BrusselsBelgium

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