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The complement system in renal diseases

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Complement and Kidney Disease

Part of the book series: Progress in Inflammation Research ((PIR))

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References

  1. Yamamoto T, Wilson CB (1987) Quantitative and qualitative studies of antibody-induced mesangial cell damage in the rat. Kidney Int 32: 514–525

    CAS  PubMed  Google Scholar 

  2. Quigg RJ (2003) Complement and the kidney. J Immunol 171: 3319–3324

    CAS  PubMed  Google Scholar 

  3. Trouw LA, Seelen MA, Daha MR (2003) Complement and renal disease. Mol Immunol 40: 125–134

    CAS  PubMed  Google Scholar 

  4. Wang Y, Hu Q, Madri AA, Rollins SA, Chodera A, Matis LA (1996) Amelioration of lupus-like autoimmune disease in NZB/W F1 mice after treatment with a blocking monoclonal antibody specific for complement component C5. Proc Natl Acad Sci USA 93: 8563–8568

    CAS  PubMed  Google Scholar 

  5. Thomas TC, Rollins SA, Rother RP, Giannoni MA, Hartman SL, Elliott EA, Nye SH, Matis LA, Squinto SP, Evans MJ (1996) Inhibition of complement activity by humanized anti-C5 antibody and single-chain Fv. Mol Immunol 33: 1389–1401

    CAS  PubMed  Google Scholar 

  6. Ravirajan CT, Wang Y, Matis LA, Papadaki L, Griffiths MH, Latchman DS, Isenberg DA (2004) Effect of neutralizing antibodies to Il-10 and C5 on the renal damage caused by a pathogenic human anti-dsDNA antibody. Rheumatology (Oxford) 43: 442–447

    Article  CAS  PubMed  Google Scholar 

  7. Edberg JC, Tosic L, Wright EL, Sutherland WM, Taylor RP (1988) Quantitative analyses of the relationship between C3 consumption, C3b capture, and immune adherence of complement-fixing antibody/DNA immune complexes. J Immunol 141: 4258–4265

    CAS  PubMed  Google Scholar 

  8. West CD (1989) The complement profile in clinical medicine: Inherited and acquired conditions lowering the serum concentrations of complement component and control proteins. Complement Inflamm 6: 49–64

    CAS  PubMed  Google Scholar 

  9. Welch TR, Beischel LS, Witte DP (1993) Differential expression of complement C3 and C4 in the human kidney. J Clin Invest 92: 1451–1458

    CAS  PubMed  Google Scholar 

  10. Wyatt RJ, Forristal J, West CD, Sugimoto S, Curd JG (1988) Complement profiles in acute post-streptococcal glomerulonephritis. Pediatr Nephrol 2: 219–223

    Article  CAS  PubMed  Google Scholar 

  11. Deppisch R, Ritz E, Hansch GM, Schols M, Rauterberg EW (1994) Bioincompatibility-perspectives in 1993. Kidney Int 44(Suppl): S77–S84

    CAS  Google Scholar 

  12. Hauser AC, Derefler K, Stockenhuber F, Janata O, Balcke P (1990) Generation of the membrane attack complex during haemodialysis: impact of classical and alternative pathway components. Clin Sci (Lond) 79: 471–476

    CAS  PubMed  Google Scholar 

  13. Innes A, Farrell AM, Burden RP, Morgan AG, Powell RJ (1994) Complement activation by cellulosic dialysis membranes. J Clin Pathol 47: 155–158

    CAS  PubMed  Google Scholar 

  14. Lhotta K, Wurzner R, Kroenenberg F, Oppermann M, Konig P (1998) Rapid activation of the complement system by cuprophane depends on complement component C4. Kidney Int 53: 1044–1051

    Article  CAS  PubMed  Google Scholar 

  15. Brunet P, Jaber K, Berland Y, Baz M (1992) Anaphylactoid reactions during hemodialysis and hemofiltration: role of associating AN69 membrane and angiotensin I-converting enzyme inhibitors. Am J Kidney Dis 19: 444–447

    CAS  PubMed  Google Scholar 

  16. Varela MP, Kimmel PL, Phillips TM, Mishkin GJ, Lew SQ, Bosch JP (2001) Biocompatibility of hemodialysis membranes: interrelations between plasma complement and cytokine levels. Blood Purif 19: 370–379

    Article  CAS  PubMed  Google Scholar 

  17. Chenoweth DE (1984) Complement activation during hemodialysis: clinical observations, proposed mechanisms, and theoretical implications. Artif Organ 8: 281–290

    CAS  Google Scholar 

  18. Inal JM, Pascual M, Lesavre P, Schifferli JA (2003) Complement inhibition in renal disease. Nephrol Dial Transplant 18: 237–240

    CAS  PubMed  Google Scholar 

  19. Kashgarian M, Hayslett JP (1989) Renal involvement in systemic lupus erythematosus. In: C Tischer, B Brenner (eds): Renal Pathology. Lippincott, Philadelphia, 389

    Google Scholar 

  20. Couser WG (1998) Pathogenesis of glomerular damage in glomerulonephritis. Nephrol Dial Transplant 13(Suppl 1): 10–15

    PubMed  Google Scholar 

  21. Walport MJ (2001) Complement. First of two parts. N Engl J Med 344: 1058–1066

    CAS  PubMed  Google Scholar 

  22. Walport MJ (2001) Complement. Second of two parts. N Engl J Med 344: 1140–1144

    CAS  PubMed  Google Scholar 

  23. Pussell BA, Bourke E, Nayef M, Morris S, Peters DK (1980) Complement deficiency and nephritis. A report of family. Lancet 1(8170): 675–677

    CAS  PubMed  Google Scholar 

  24. Roord JJ, van Diemen-van, Stennvorde RA, Shuurman HJ, Rijkers GT, Zegers BJ, Gmelig Meyling FH, Stoop JW (1989) Membranoproliferative glomerulonephritis in a patient with congenital dericiency of the third component of complement: effect of treatment with plasma. Am J Kidney Dis 205: 595–609

    Google Scholar 

  25. Hironaka K, Makino H, Amano T, Ota Z (1993) Immune complex glomerulonephritis in a pregnant woman with congenital C9 deficiency. Intern Med 32: 806–809

    CAS  PubMed  Google Scholar 

  26. Yoshioka K, Takemura T, Akano N, Okada M, Yagi K, Maki S, Inai S, Akita H, Koitabashi Y, Takekoshi Y (1992) IgA nephropathy in patients with congenital C9 deficiency. Kidney Int 42: 1253–1258

    CAS  PubMed  Google Scholar 

  27. Rosenberg ME, Girton R, Finkel D, Chmielewski D, Barrie IIIA, Witte DP, Zhu G, Bissler JJ, Harmony JA, Aronow BJ (2002) Apolipoprotein J/clusterin prevents a progressive glomerulopathy of aging. Mol Cell Biol 22: 1893–1902

    Article  CAS  PubMed  Google Scholar 

  28. Ault BH (2000) Factor H and the pathogenesis of renal diseases. Pediatr Nephrol 14: 1045–1053

    Article  CAS  PubMed  Google Scholar 

  29. Levy M, Halbach-Mecarelli L, Gubler MC, Kohout G, Bensenouci A, Niaudet P, Hauptmann G, Lesavre P (1986) H deficiency in two brothers with atypical dense intramem-branous deposit disease. Kidney Int 30: 949–956

    CAS  PubMed  Google Scholar 

  30. Hogasen K, Jansen JH (1995) Porcine membranoproliferative glomerulonephritis type II is caused by factor H deficiency. J Clin Invest 95: 1054–1061

    CAS  PubMed  Google Scholar 

  31. Jansen JH, Hogasen K, Harboe M, Hovig T (1998) In situ complement activation in porcine membranoproliferative glomerulonephritis type II. Kidney Int 53: 331–349

    Article  CAS  PubMed  Google Scholar 

  32. Pickering MC, Cook HT, Warren J, Bygrave AER, Moss J, Walport MJ, Botto M (2002) Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H. Nat Genet 31:424–428

    CAS  PubMed  Google Scholar 

  33. Sadallah S, Gudat F, Laissue JA, Spath PJ, Schifferli JA (1999) Glomerulonephritis in a patient with complement factor I deficiency. Am J Kidney Dis 33: 1153–1157

    CAS  PubMed  Google Scholar 

  34. Daha MR, Fearon DT, Austen KF (1976) C3 nephritic factor (C3NeF): stabilization of fluid phase and cell-bound alternative pathway convertase. J Immunol 116: 1–7

    CAS  PubMed  Google Scholar 

  35. Daha MR, van Es LA (1979) Further evidence for the antibody nature of C3 nephritic factor (C3Nef). J Immunol 123: 755–758

    CAS  PubMed  Google Scholar 

  36. Daha MR, van Es LA (1980) Relative resistance of the F-42 stabilized classical pathway C3 convertase to inactivation by C4-binding protein. J Immunol 125: 2051–2054

    CAS  PubMed  Google Scholar 

  37. Halbwachs L, Leveille M, Lesavre P, Wattel S, Leibowitch J (1980) Nephritic factor of the classical pathway of complement: immunoglobulin G autoantibody directed against the classical pathway C3 convertase enzyme. J Clin Invest 65: 1249–1256

    CAS  PubMed  Google Scholar 

  38. Hrick DE, Chung-Park M, Sedor JR (1998) Glomerulonephritis. N Engl J Med 339: 888–899

    Google Scholar 

  39. Varade WS, Forristal J, West CD (1990) Patterns of complement activation in idiopathic membranoproliferative glomerulonephritis, types I, II and III. Am J Kidney Dis 16: 196–206

    CAS  PubMed  Google Scholar 

  40. Mathieson PW, Wurzner R, Oliveria DB, Lachmann PJ, Peters DK (1993) Complement-mediated adipocyte lysis by nephritic factor sera. J Exp Med 177: 1827–1831

    CAS  PubMed  Google Scholar 

  41. Jasin HE (1979) Systemic lupus erythematosus, partial lipodistrophy and hypocomplementemia. J Rheumatol 6: 43–50

    CAS  PubMed  Google Scholar 

  42. Fremeaux-Bacchi V, Weiss L, Demouchy C, May A, Palomera S, Kazatchkine MD (1995) Hypocomplementaemia of poststreptococcal acute glomerulonephritis is associated with C3 nephritic factor (C3NeF) IgG autoantibody activity. Nephrol Dial Transplant 10: 1782–1783

    Google Scholar 

  43. Gewurz AT, Imherr SM, Strauss S, Gewurz H, Mold C (1983) C3 nephritic factor and hypocomplementemia in a clinically healthy individual. Clin Exp Immunol 54: 253–258

    CAS  PubMed  Google Scholar 

  44. Sissons JG, West RJ, Fallows J, Williams DG, Boucher BJ, Amos N, Peters DK (1976) The complement abnormalities of lipodystrophy. N Engl J Med 294: 461–465

    CAS  PubMed  Google Scholar 

  45. Spitzer RE, Stitzel AE, Tsokos G (1992) On the origin of C3 nephritic factor (antibody to alternative pathway C3 convertase): evidence for the Adam and Eve concept of autoantibody production. Clin Immunol Immunopathol 64: 177–183

    Article  CAS  PubMed  Google Scholar 

  46. Mollnes TE, Ng YC, Peters DK, Lea T, Tshopp J, Harboe M (1986) Effect of nephritic factor on C3 and on the terminal pathway of complement in vivo and in vitro. Clin Exp Immunol 65: 73–79

    CAS  PubMed  Google Scholar 

  47. Tanuma Y, Ohi H, Hatano M (1990) Two types of C3 nephritic factor: properdin-dependent C3NeF and properdin-independent C3NeF. Clin Immunol Immunopathol 56: 226–238

    Article  CAS  PubMed  Google Scholar 

  48. Ohi H, Yasugi T (1994) Occurrence of C3 nephritic factor and C4 nephritic factor in membranoproliferative glomerulonephritis (MPGN). Clin Exp Immunol 95: 316–321

    CAS  PubMed  Google Scholar 

  49. Jokiranta TS, Solomon A, Pangburn MK, Zipfel PF, Meri S (1999) Nephritogenic lambda light chain dimmer: a unique human miniautoantibody against complement factor H. J Immunol 163: 4590–4596

    CAS  PubMed  Google Scholar 

  50. Horvath L, Czirjak L, Fekete B, Jakab L, Pozsonyi T, Kalabay L, Romics MR, Miklos K, Varga L, Prohaszka Z et al (2001) High levels of antibodies against C1q are associated with disease actibvity and nephritis but not with other organ manifestations in SLE patients. Clin Exp Rheumatol 19: 667–672

    CAS  PubMed  Google Scholar 

  51. Siegert C, Daha M, Westedt ML, van der Voort E, Breedveld F (1991) IgG autoantibodies against C1q are correlated with nephritis, hypocomplementemia and dsDNA antibodies in systemic lupus erythematosus. J Rheumatol 18: 230–234

    CAS  PubMed  Google Scholar 

  52. Siegert CE, Daha MR, Halma C, van der Voort EA, Breedveld FC (1992) IgG and IgA autoantibodies to C1q in systemic and renal diseases. Clin Exp Rheumatol 10: 19–23

    CAS  PubMed  Google Scholar 

  53. Coremans IE, Spronk PE, Bootsma H, DSaha MR, van der Voort EA, Kater L, Breedveld FC, Kallenberg CG (1995) Changes in antibodies to C1q predict renal relapses in systemic lupus erythematosus. Am J Kidney Dis 26: 595–601

    CAS  PubMed  Google Scholar 

  54. Trendelenburg M, Marfurt J, Gerber I, Tyndall A, Schifferli JA (1999) Lack of occurrence of severe lupus nephritis among anti-C1q autoantibody negative patients. Arthritis Rheumatol 42: 187–188

    CAS  Google Scholar 

  55. Mannik M, Werner MH (1997) Deposition of antibodies to the collagen-like region of C1q in renal glomeruli of patients with proliferative lupus glomerulonephritis. Arthritis Rheum 40: 1504–1511

    CAS  PubMed  Google Scholar 

  56. Siegert CE, Daha MR, Swaak AJ, van der Voort EA, Breedveld FC (1993) The relationship between serum titers of autoantibodies to lupus erythematosus. Clin Immunol Immunopathol 67: 204–209

    Article  CAS  PubMed  Google Scholar 

  57. Pickering MC, Botto M, Taylor PR, Lachmann PJ, Walport MJ (2000) Systemic lupus erythematosus, complement deficiency, and apoptosis. Adv Immunol 76: 227–324

    CAS  PubMed  Google Scholar 

  58. Walport MJ, Davies KA, Morley BJ, Botto M (1997) Complement deficiency and autoimmunity. Ann NY Acad Sci 815: 267–281

    CAS  PubMed  Google Scholar 

  59. Lachmann PJ (1961) An attempt to characterize the lupus erythematosus cell antigen. Immunology 4: 153–163

    CAS  PubMed  Google Scholar 

  60. Pan CG, Strife CF, Ward MK, Spitzer RE, McAdams AJ (1992) Long-term follow-up of non-systemic lupus erythematosus glomerulonephritis in patients with hereditary angioedema: report of four cases. Am J Kidney Dis 19: 526–531

    CAS  PubMed  Google Scholar 

  61. Wisnieski JJ, Emancipator SN, Korman NJ, Lass JH, Zaim TM, McFadden ER (1994) Hypocomplementemic urticarial vasculitis syndrome in identical twins. Arthritis Rheum 37: 1105–1111

    CAS  PubMed  Google Scholar 

  62. Emancipator SN (1994) IgA nephropathy: morphologic expression and pathogenesis. Am J Kidney Dis 23: 451–462

    CAS  PubMed  Google Scholar 

  63. O’Donoghue DJ, Darvill A, Baillardie W (1991) Mesangial cell autoantigens in immunoglobulin A nephropathy and henoch-Schonlein Purpura. J Clin Invest 88: 1522–1530

    CAS  PubMed  Google Scholar 

  64. Rits M, Hiemstra PS, Bazin H, Van Es LA, Voerman JP, Daha MR (1988) Activation of rat complement by soluble and insoluble rat IgA immune complexes. Eur J Immunol 18: 1873–1880

    CAS  PubMed  Google Scholar 

  65. Rauterberg EW, Lieberknecht HM, Wingen AM, Ritz E (1987) Complement membrane attack (MAC) in idiopathic IgA-glomerulonephritis. Kidney Int 31: 820–829

    CAS  PubMed  Google Scholar 

  66. Brandt J, Pippin J, Shulze M, Mansche GM, Alpers CE, Johnson RJ, Gordon K, Couser WG (1996) Role of the complement membrane attack complex (C5-9) in mediating experimental mesangioproliferative glomerulonephritis. Kidney Int 49: 335–343

    CAS  PubMed  Google Scholar 

  67. Nangaku M, Pippin J, Shankland SJ, Johnson RJ, Couser WG (1997) Renal microvascular injury induced by the antibody to glomerular endothelial cells is mediated by C5b-9. Kidney Int 52: 1570–1578

    CAS  PubMed  Google Scholar 

  68. Couser WG (1999) Glomerulonephritis. Lancet 353: 1509–1515

    Article  CAS  PubMed  Google Scholar 

  69. Cameron JS, Vick RM, Ogg CS, Seymour WM, Chantler C, Turner DR (1973) Plasma C3 and C4 concentrations in management of glomerulonephritis. Brit Med J 3: 668–672

    CAS  PubMed  Google Scholar 

  70. Floege J, Feehally J (2000) IgA nephropathy: recent developments. J Am Soc Nephrol 11: 2395–2403

    CAS  PubMed  Google Scholar 

  71. Montinaro V, Lopez A, Monno R, Cappiello V, Manno C, Gesualdo L, Schena FP (2000) Renal C3 synthesis in idiopathic membranous nephropathy: correlation to urinary C5b-9 excretion. Kidney Int 57: 137–146

    Article  CAS  PubMed  Google Scholar 

  72. Newman DJ, Thakkar H, Gallagher H (2000) Progressive renal disease: does the quality of the proteinuria matter or only the quantity? Clin Chim Acta 297: 43–54

    Article  CAS  PubMed  Google Scholar 

  73. Tang S, Lai KN, Sacks SH (2002) Role of complement in tubulointerstitial injury from proteinuria. Kidney Blood Press Res 25: 120–126

    Article  CAS  PubMed  Google Scholar 

  74. Van Kooten C, Langers AM, Bruijn JA, Daha MR (1999) Role of tubular cells in progressive renal disease. Kidney Blood Press Res 22: 53–61

    PubMed  Google Scholar 

  75. Ischida S, Yuzawa Y, Okada H, Yoshioka K, Matsuo S (1994) Localization of the complement regulatory proteins in the normal human kidney. Kidney Int 46: 89–96

    Google Scholar 

  76. Nangaku M (1998) Complement regulatory proteins in glomerular diseases. Kidney Int 54: 1419–1428

    Article  CAS  PubMed  Google Scholar 

  77. Springall T, Sheerin NS, Abe K, Holers VM, Wan H, Sacks SH (2001) Epithelial secretion of C3 promotes colonization of the upper urinary tract by Escherichia coli. Nat Med 7: 801–806

    Article  CAS  PubMed  Google Scholar 

  78. Pratt JR, Basheer SA, Sacks SH (2002) Local synthesis of complement component C3 regulates acute renal transplant rejection. Nat Med 8: 582–587

    Article  CAS  PubMed  Google Scholar 

  79. Dooldeniya MD, Warrens AN (2003) Xenotransplantation: where are we today? J R Soc Med 96: 111

    Article  CAS  PubMed  Google Scholar 

  80. Coopper DK, Gollackner B, Sach DH (2002) Will pig solve the transplantation backlog? Annu Rev Med 53: 133

    Google Scholar 

  81. Mauiyyedi S, Pelle PD, Saidman S, Collins AB, Pascual M, Tolkoff-Rubin NE, Williams WW, Cosimi AA, Schneeberger EE, Colvin RB (2001) Chronic humoral rejection: identification of antibody-mediated chronic renal allograft rejection by C4d deposits in peritubular capillaries. J Am Soc Nephrol 12: 574–582

    CAS  PubMed  Google Scholar 

  82. Wilson DM, Salazer TL, Farkouh ME (1991) Eosinophiluria in atheroembolic renal disease. Am J Med 91: 186–189

    Article  CAS  PubMed  Google Scholar 

  83. Cosio FG, Zager RA, Sharma HM (1985) Atheroembolic renal disease causes hypocomplementemia. Lancet 2: 118–121

    CAS  PubMed  Google Scholar 

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  1. Centre for Veterinary Science, Madingley Road, Cambridge, CB3 0ES, UK

    Momir Macanovic & Peter Lachmann

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  1. Momir Macanovic
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  2. Peter Lachmann
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  1. Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Beutenbergstr. 11a, D-07745, Jena, Germany

    Peter F. Zipfel

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Macanovic, M., Lachmann, P. (2006). The complement system in renal diseases. In: Zipfel, P.F. (eds) Complement and Kidney Disease. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7428-4_1

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