Conclusion
There is an abundant literature available regarding the involvement of NPY in airway homeostasis. However, there is no NPY-related therapeutic agent yet available or under clinical development for the treatment of airway diseases. Several aspects regarding the role of NPY in the physiological control of airway function and immunological mechanisms suggest that the development of selective agonists and antagonist should have potential therapeutic applications.
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References
Proetz AW (1953) Respiratory air currents and their clinical aspects. J Laryngol Otol 67(1): 1–27
Cole P (1954) Respiratory mucosal vascular responses, air conditioning and thermo regulation. J Laryngol Otol 68(9): 613–622
Cole P (1954) Recordings of respiratory air temperature. J Laryngol Otol 68(5): 295–307
Williams HL (1973) Nasal physiology. In: WB Saunders (ed): Otolaryngology. Philadelphia, p. 330
Barnes PJ, Baraniuk JN, Belvisi MG (1991) Neuropeptides in the respiratory tract. Part I. Am Rev Respir Dis 144: 1187–1198
Barnes PJ, Baraniuk JN, Belvisi MG (1991) Neuropeptides in the respiratory tract. Part II. Am Rev Respir Dis 144(6): 1391–1399
Dahlström A, Fuxe K (1965) The adrenergic innervation of the nasal mucosa in certain mammals. Acta Otolaryngol 59: 65–72
Anggard A, Densert O (1974) Adrenergic innervation of the nasal mucosa in cat. A histological and physiological study. Acta Otolaryngol 78(3-4): 232–241
Cauna N (1970) The fine structure of the arteriovenous anastomosis and its nerve supply in the human nasal respiratory mucosa. Anat Rec 168(1): 9–21
Cauna N (1970) Electron microscopy of the nasal vascular bed and its nerve supply. Ann Otol Rhinol Laryngol 79(3): 443–450
von Euler US (1948) Identification of the sympathomimetic ergone in adrenergic nerves of cattle (Sympathetin N) with laevonoradrenaline. Acta Physiol Scand 16: 63–74
Tatemoto K, Carlquist M, Mutt V (1982) Neuropeptide Y — a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature 296(5858): 659–660
Lacroix JS, Stjarne P, Anggard A, Lundberg JM (1989) Sympathetic vascular control of the pig nasal mucosa (III): Co-release of noradrenaline and neuropeptide Y. Acta Physiol Scand 135(1): 17–28
Lacroix JS, Anggard A, Hokfelt T, O’Hare MM, Fahrenkrug J, Lundberg JM (1990) Neuropeptide Y: presence in sympathetic and parasympathetic innervation of the nasal mucosa. Cell Tissue Res 259(1): 119–128
Baraniuk JN, Castellino S, Lundgren JD, Goff J, Mullol J, Merida M, Shelhamer JH, Kaliner MA (1990) Neuropeptide Y (NPY) in human nasal mucosa. Am J Respir Cell Mol Biol 3(2): 165–173
Sheppard MN, Polak JM, Allen JM, Bloom SR (1984) Neuropeptide tyrosine (NPY): a newly discovered peptide is present in the mammalian respiratory tract. Thorax 39(5): 326–330
Widdicombe JG (1991) Neural control of airway vasculature and edema. Am Rev Respir Dis 143(3 Pt 2): S18–S21
Lacroix JS, Auberson S, Morel DR, Theodorsson E, Hokfelt T, Lundberg JM (1992) Vascular control of the pig nasal mucosa: distribution and effect of somatostatin in relation to noradrenaline and neuropeptide Y. Regul Pept 40(3): 373–387
Heppt W, Peiser C, Cryer A, Dinh QT, Zweng M, Witt C, Fischer A, Groneberg DA (2002) Innervation of human nasal mucosa in environmentally triggered hyperreflectoric rhinitis. J Occup Environ Med 44(10): 924–929
Groneberg DA, Heppt W, Cryer A, Wussow A, Peiser C, Zweng M, Dinh QT, Witt C, Fischer A (2003) Toxic rhinitis-induced changes of human nasal mucosa innervation. Toxicol Pathol 31(3): 326–331
Groneberg DA, Heppt W, Welker P, Peiser C, Dinh QT, Cryer A, Zweng M, Witt C, Fischer A (2003) Aspirin-sensitive rhinitis-associated changes in upper airway innervation. Eur Respir J 22(6): 986–991
Lacroix JS, Stjarne P, Anggard A, Lundberg JM (1988) Sympathetic vascular control of the pig nasal mucosa (2): Reserpine-resistant, non-adrenergic nervous responses in relation to neuropeptide Y and ATP. Acta Physiol Scand 133(2): 183–197
Cervin A (1992) Neuropeptide Y 16-36 inhibits mucociliary activity but does not affect blood flow in the rabbit maxillary sinus in vivo. Regul Pept 39(2-3): 237–246
Lacroix JS, Ricchetti AP, Morel D, Mossimann B, Waeber B, Grouzmann E (1996) Intranasal administration of neuropeptide Y in man: systemic absorption and functional effects. Br J Pharmacol 118(8): 2079–2084
Cervin A, Onnerfalt J, Edvinsson L, Grundemar L (1999) Functional effects of neuropeptide Y receptors on blood flow and nitric oxide levels in the human nose. Am J Respir Crit Care Med 160(5 Pt 1): 1724–1728
Baraniuk JN, Silver PB, Kaliner MA, Barnes PJ (1992) Neuropeptide Y is a vasoconstrictor in human nasal mucosa. J Appl Physiol 73(5): 1867–1872
Widdicombe JG (1990) The NANC system and airway vasculature. Arch Int Pharmacodyn Ther 303: 83–99
Laitinen LA, Laitinen A, Salonen RO, Widdicombe JG (1987) Vascular actions of airway neuropeptides. Am Rev Respir Dis 136(6 Pt 2): S59–S64
Salonen RO, Webber SE, Widdicombe JG (1988) Effects of neuropeptides and capsaicin on the canine tracheal vasculature in vivo. Br J Pharmacol 95(4): 1262–1270
Matran R (1991) Neural control of lower airway vasculature. Involvement of classical transmitters and neuropeptides. Acta Physiol Scand (Suppl) 601: 1–54
Franco-Cereceda A, Matran R, Alving K, Lundberg JM (1995) Sympathetic vascular control of the laryngeo-tracheal, bronchial and pulmonary circulation in the pig: evidence for non-adrenergic mechanisms involving neuropeptide Y. Acta Physiol Scand 155(2): 193–204
Mullol J, Rieves RD, Baraniuk JN, Lundgren JD, Merida M, Hausfeld JH, Shelhamer JH, Kaliner MA (1992) The effects of neuropeptides on mucous glycoprotein secretion from human nasal mucosa in vitro. Neuropeptides 21(4): 231–238
Lacroix JS, Mosimann BL (1996) Attenuation of allergen-evoked nasal responses by local pretreatment with exogenous neuropeptide Y in atopic patients. J Allergy Clin Immunol 98(3): 611–616
Michel MC, Beck-Sickinger A, Cox H, Doods HN, Herzog H, Larhammar D, Quirion R, Schwartz T, Westfall T (1998) XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol Rev 50(1): 143–150
Grundemar L (1997) Characterization of the receptor response for the neuropeptide Yevoked suppression of parasympathetically-mediated contractions in the guinea pig trachea. Regul Pept 71(2): 97–101
Landis BN, Grouzman E, Lacroix JS (2005) Modulation of histamine induced bronchoconstriction after DPP IV pretreatment. Regul Pept; in press
Pernow J, Lundberg JM, Kaijser L, Hjemdahl P, Theodorsson-Norheim E, Martinsson A, Pernow B (1986) Plasma neuropeptide Y-like immunoreactivity and catecholamines during various degrees of sympathetic activation in man. Clin Physiol 6(6): 561–578
Richerson HB, Seebohm PM (1968) Nasal airway response to exercise. J Allergy 41(5): 269–284
Dallimore NS, Eccles R (1977) Changes in human nasal resistance associated with exercise, hyperventilation and rebreathing. Acta Otolaryngol 84(5-6): 416–421
Lacroix JS, Correia F, Fathi M, Grouzmann E (1997) Post-exercise nasal vasoconstriction and hyporeactivity: possible involvement of neuropeptide Y. Acta Otolaryngol 117(4): 609–613
Stretton CD, Barnes PJ (1988) Modulation of cholinergic neurotransmission in guineapig trachea by neuropeptide Y. Br J Pharmacol 93(3): 672–678
Matran R, Martling CR, Lundberg JM (1989) Inhibition of cholinergic and non-adrenergic, non-cholinergic bronchoconstriction in the guinea pig mediated by neuropeptide Y and alpha 2-adrenoceptors and opiate receptors. Eur J Pharmacol 163(1): 15–23
Lacroix JS, Ulman LG, Potter EK (1994) Sympathetic and parasympathetic interaction in vascular control of the nasal mucosa in anaesthetized cats. J Physiol 480(Pt 2): 325–331
Potter EK, Barden JA, McCloskey MJ, Selbie LA, Tseng A, Herzog H, Shine J (1994) A novel neuropeptide Y analog, N-acetyl [Leu28,Leu31]neuropeptide Y-(24-36), with functional specificity for the presynaptic (Y2) receptor. Eur J Pharmacol 267(3): 253–262
Lacroix JS, Ulman LG, Potter EK (1994) Modulation by neuropeptide Y of parasympathetic nerve-evoked nasal vasodilatation via Y2 prejunctional receptor. Br J Pharmacol 113(2): 479–484
Herzog H, Hort YJ, Ball HJ, Hayes G, Shine J, Selbie LA (1992) Cloned human neuropeptide Y receptor couples to two different second messenger systems. Proc Natl Acad Sci USA 89(13): 5794–5798
Revington M, Lacroix JS, Potter EK (1997) Sympathetic and parasympathetic interaction in vascular and secretory control of the nasal mucosa in anaesthetized dogs. J Physiol 505(Pt 3): 823–831
Stretton CD, Belvisi MG, Barnes PJ (1990) Neuropeptide Y modulates non-adrenergic, non-cholinergic neural bronchoconstriction in vivo and in vitro. Neuropeptides 17(4): 163–170
Benchekroun TM, Fournier A, St-Pierre S, Cadieux A (1992) Inhibitory action of neuropeptide Y on agonist-induced responses in isolated guinea pig trachea. Eur J Pharmacol 216(3): 421–428
Grouzmann E, Buclin T, Martire M, Cannizzaro C, Dorner B, Razaname A, Mutter M (1997) Characterization of a selective antagonist of neuropeptide Y at the Y2 receptor. Synthesis and pharmacological evaluation of a Y2 antagonist. J Biol Chem 27(12): 7699–7706
Malis DD, Grouzmann E, Morel DR, Mutter M, Lacroix LS (1999) Influence of TASPV, a novel neuropeptide Y (NPY) Y2 agonist, on nasal and bronchial responses evoked by histamine in anaesthetized pigs and in humans. Br J Pharmacol 126(4): 989–996
Takahashi T, Ichinose M, Yamauchi H, Miura M, Nakajima N, Ishikawa J, Inoue H, Takishima T, Shirato K (1993) Neuropeptide Y inhibits neurogenic inflammation in guinea pig airways. J Appl Physiol 75(1): 103–107
Nadelhaft I, Vera PL (1991) Neurons labelled after the application of tracer to the distal stump of the transected hypogastric nerve in the rat. J Auton Nerv Syst 36(2): 87–96
Fujiwara H, Kurihara N, Hirata K, Ohta K, Kanazawa H, Takeda T (1993) Effect of neuropeptide Y on human bronchus and its modulation of neutral endopeptidase. J Allergy Clin Immunol 92(1 Pt 1): 89–94
Lacroix JS, Kurt AM, Pochon N, Bretton C, Lundberg JM, Deshusses J (1995) Neutral endopeptidase activity and concentration of sensory neuropeptide in the human nasal mucosa. Eur Arch Otorhinolaryngol 252(8): 465–468
Grouzmann E, Monod M, Landis B, Wilk S, Brakch N, Nicoucar K, Giger R, Malis D, Szalay-Quinodoz I, Cavadas C, et al. (2002) Loss of dipeptidylpeptidase IV activity in chronic rhinosinusitis contributes to the neurogenic inflammation induced by substance P in the nasal mucosa. FASEB J 16(9): 1132–1134
Chung F (2001) Anti-inflammatory cytokines in asthma and allergy: interleukin-10, interleukin-12, interferon-gamma. Mediators Inflamm 10(2): 51–59
Kawamura N, Tamura H, Obana S, Wenner M, Ishikawa T, Nakata M, Yamamoto H (1998) Differential effects of neuropeptides on cytokine production by mouse helper T cell subsets. Neuroimmunomodulation 5(1-2): 9–15
Bedoui S, Kawamura N, Straub RH, Pabst R, Yamamura T, von Horsten S (2003) Relevance of neuropeptide Y for the neuroimmune crosstalk. J Neuroimmunol 134(1-2): 1–11
Levite M (1998) Neuropeptides, by direct interaction with T cells, induce cytokine secretion and break the commitment to a distinct T helper phenotype. Proc Natl Acad Sci USA 95(21): 12544–12549
Levite M (2000) Nerve-driven immunity. The direct effects of neurotransmitters on Tcell function. Ann NY Acad Sci 917: 307–321
Bradding P (2003) The role of the mast cell in asthma: a reassessment. Curr Opin Allergy Clin Immunol 3(1): 45–50
Groneberg DA, Welker P, Fischer TC, Dinh QT, Grutzkau A, Peiser C, Wahn U, Henz BM, Fischer A (2003) Down-regulation of vasoactive intestinal polypeptide receptor expression in atopic dermatitis. J Allergy Clin Immunol 111(5): 1099–1105
Mousli M, Trifilieff A, Pelton JT, Gies JP, Landry Y (1995) Structural requirements for neuropeptide Y in mast cell and G protein activation. Eur J Pharmacol 289(1): 125–133
Emadi-Khiav B, Mousli M, Bronner C, Landry Y (1995) Human and rat cutaneous mast cells: involvement of a G protein in the response to peptidergic stimuli. Eur J Pharmacol 272(1): 97–102
Shen GH, Grundemar L, Zukowska-Grojec Z, Hakanson R, Wahlestedt C (1991) C-terminal neuropeptide Y fragments are mast cell-dependent vasodepressor agents. Eur J Pharmacol 204(3): 249–256
Cross LJ, Beck-Sickinger AG, Bienert M, Gaida W, Jung G, Krause E, Ennis M (1996) Structure activity studies of mast cell activation and hypotension induced by neuropeptide Y (NPY), centrally truncated and C-terminal NPY analogues. Br J Pharmacol 117(2): 325–332
Grundemar L, Krstenansky JL, Hakanson R (1994) Neuropeptide Y and truncated neuropeptide Y analogs evoke histamine release from rat peritoneal mast cells. A direct effect on G proteins? Eur J Pharmacol 258(1-2): 163–166
Barnes PJ (2001) Cytokine modulators as novel therapies for airway disease. Eur Respir J Suppl 34: 67s–77s
Barnes PJ (2001) Cytokine modulators for allergic diseases. Curr Opin Allergy Clin Immunol 1(6): 555–560
Bowler RP, Crapo JD (2002) Oxidative stress in airways: is there a role for extracellular superoxide dismutase? Am J Respir Crit Care Med 166(12 Pt 2): S38–S43
Henricks PA, Nijkamp FP (2001) Reactive oxygen species as mediators in asthma. Pulm Pharmacol Ther 14(6): 409–420
De la Fuente M, Del Rio M, Medina S (2001) Changes with aging in the modulation by neuropeptide Y of murine peritoneal macrophage functions. J Neuroimmunol 116(2): 156–167
Dimitrijevic M, Stanojevic S, Vujic V, Kovacevic-Jovanovic V, Beck-Sickinger A, Demuth H, von Horsten S (2002) Effect of neuropeptide Y on inflammatory paw edema in the rat: involvement of peripheral NPY Y1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26). J Neuroimmunol 129(1-2): 35–42
von Horsten S, Ballof J, Helfritz F, Nave H, Meyer D, Schmidt RE, Stalp M, Klemm A, Tschernig T, Pabst R (1998) Modulation of innate immune functions by intracerebroventricularly applied neuropeptide Y: dose and time dependent effects. Life Sci 63(11): 909–922
von Horsten S, Exton NG, Exton MS, Helfritz F, Nave H, Ballof J, Stalp M, Pabst R (1998) Brain NPY Y1 receptors rapidly mediate the behavioral response to novelty and a compartment-specific modulation of granulocyte function in blood and spleen. Brain Res 806(2): 282–286
von Horsten S, Nave H, Ballof J, Helfritz F, Meyer D, Schmidt RE, Stalp M, Exton NG, Exton MS, Straub RH, et al. (1998) Centrally applied NPY mimics immunoactivation induced by non-analgesic doses of met-enkephalin. Neuroreport 9(17): 3881–3885
Song C, Leonard BE (1998) Comparison between the effects of sigma receptor ligand JO 1784 and neuropeptide Y on immune functions. Eur J Pharmacol 345(1): 79–87
Straub RH, Schaller T, Miller LE, von Horsten S, Jessop DS, Falk W, Scholmerich J (2000) Neuropeptide Y cotransmission with norepinephrine in the sympathetic nervemacrophage interplay. J Neurochem 75(6): 2464–2471
Howarth PH, Springall DR, Redington AE, Djukanovic R, Holgate ST, Polak JM (1995) Neuropeptide-containing nerves in endobronchial biopsies from asthmatic and nonasthmatic subjects. Am J Respir Cell Mol Biol 13(3): 288–296
Chanez P, Springall D, Vignola AM, Moradoghi-Hattvani A, Polak JM, Godard P, Bousquet J (1998) Bronchial mucosal immunoreactivity of sensory neuropeptides in severe airway diseases. Am J Respir Crit Care Med 158(3): 985–990
Dahlof C, Dahlof P, Lundberg JM, Strombom U (1988) Elevated plasma concentration of neuropeptide Y and low level of circulating adrenaline in elderly asthmatics during rest and acute severe asthma. Pulm Pharmacol 1(1): 3–6
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Landis, B.N., Plouin-Gaudon, I., Lacroix, JS. (2005). NPY in allergic and respiratory disorders. In: Zukowska, Z., Feuerstein, G.Z. (eds) The NPY Family of Peptides in Immune Disorders, Inflammation, Angiogenesis and Cancer. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7427-6_7
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