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Gene-based large scale LD-mapping of rheumatoid arthritis-associated genes

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The Hereditary Basis of Rheumatic Diseases

Part of the book series: Progress in Inflammation Research ((PIR))

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Summary

Large-scale LD mapping has been successful at identifying RA-associated polymorphisms. Interestingly they seemed to identify RA-specific gene(s) and also gene(s) that contribute to multiple autoimmune diseases. Another important issue in the investigation of disease-associated polymorphisms is that polymorphisms vary among ethnic groups; therefore genetic studies should be carefully and extensively carried out with special attention paid to ethnic variations in polymorphisms and combinations of multiple genes.

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Authors and Affiliations

  1. Laboratory for Rheumatic Diseases, SNP Research Center (E508), RIKEN, 1-7-22 Suehirocho, Tsurumi-ku, Yokohama, Kanagawa-ken, 230-0045, Japan

    Ryo Yamada & Kazuhiko Yamamoto

  2. Department of allergy and rheumatology, Graduate school of medicine, University of Tokyo, Tokyo, 113-8655, Japan

    Kazuhiko Yamamoto

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  1. Ryo Yamada
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  2. Kazuhiko Yamamoto
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  1. Section for Medical Inflammation Research, Department of Cell and Molecular Biology, Lund University, Solvegatan 19, I11 BMC, S-221 84, Lund, Sweden

    Rikard Holmdahl

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© 2006 Birkhäuser Verlag Basel/Switzerland

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Yamada, R., Yamamoto, K. (2006). Gene-based large scale LD-mapping of rheumatoid arthritis-associated genes. In: Holmdahl, R. (eds) The Hereditary Basis of Rheumatic Diseases. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7419-5_4

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  • DOI: https://doi.org/10.1007/3-7643-7419-5_4

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-7643-7201-9

  • Online ISBN: 978-3-7643-7419-8

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