Neuropeptide Y and the cerebral circulation

  • Lars Edvinsson
Part of the Experientia Supplementum book series (EXS, volume 95)

Concluding remarks

The presence of NPY receptors on both endothelial and vascular smooth muscle cells indicates that blood-borne NPY as well as NPY stemming from surrounding nerves can affect contractile responses of cerebral vessels. In addition, endothelial cells may themselves be a source of NPY as well as a site of NPY metabolism. Understanding the roles of NPY in cerebrovascular regulation is complicated by multiple receptor subtypes, signalling pathways and cellular responses. Vasodilatory effects and vascular remodeling actions underscore the fact that NPY cannot just be classified as a potent vasoconstrictor. NPY is an important sympathetic transmitter, but it clearly acts via intracerebral nerves as well to regulate local CBF.


Cerebral Blood Flow Middle Cerebral Artery Occlusion Cerebral Vasospasm Cerebral Circulation Cereb Blood Flow 
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Copyright information

© Birkhäuser Verlag/Switzerland 2006

Authors and Affiliations

  • Lars Edvinsson
    • 1
  1. 1.Division of Experimental Vascular Research, Department of Internal MedicineLund University HospitalLundSweden

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