Modulator role of neuropeptide Y in human vascular sympathetic neuroeffector junctions

  • M. Verónica Donoso
  • Ana María Delpiano
  • J. Pablo Huidobro-Toro
Part of the Experientia Supplementum book series (EXS, volume 95)

Summary

Reverse transcription polymerase chain reaction (RT-PCR) studies identified the mRNA coding for the Y1 and Y2 receptors in human mammary artery/vein and saphenous vein biopsies. Y1 receptors are expressed in vascular smooth muscles and potentiate the contractile action of sympathetic co-transmitters, adenosine triphosphate (ATP) and noradrenaline (NA); BIBP 3226, a competitive Y1 receptor antagonist, blocked the neuropeptide Y (NPY)-induced modulation. The Y2 receptor is expressed in sympathetic nerves terminals and modulates the pool of sympathetic co-transmitters released at the neuroeffector junction. NPY plays a dual role as a modulator of sympathetic co-transmission; it facilitates vascular smooth muscle reactivity and modulates the presynaptic release of ATP and NA. Sympathetic reflexes regulate human vascular resistance, where NPY plays a modulator role of paramount importance following increased sympathetic discharges, such as stress and vascular disease.

Keywords

Reverse Transcription Polymerase Chain Reaction Modulator Role Sympathetic Nerve Terminal Human Saphenous Vein Sympathetic Discharge 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag/Switzerland 2006

Authors and Affiliations

  • M. Verónica Donoso
    • 1
  • Ana María Delpiano
    • 1
  • J. Pablo Huidobro-Toro
    • 1
  1. 1.J.V. Luco Center for Cell Regulation and Pathology, Millenium Institute for Fundamental and Applied Biology, Dept. Physiology, Neurohumoral Regulation Unit, Faculty of Biological SciencesP. Catholic University of ChileSantiagoChile

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