Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Mokdad A, Ford E, Bowman B, Dietz W, Vinicor F, Bales V, Marks J (2003) Prevalence of obesity, diabetes, and obesity related health risk factors. JAMA 289: 76–79
Stanley B, Leibowitz S (1985) Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior. PNAS 82: 3940–3943
Halaas J, Gajiwala K, Maffei M, Cohen S, Chait B, Rabinowitz D, Lallone R, Burley S, Friedman J (1995) Weight reducing effects of the plasma protein encoded by the obese gene. Science 269: 543–546
Stanley B, Magdalin W, Seirafi A, Nguyen M, Leibowitz S (1992) Evidence for neuropeptide Y mediation of eating produced by food deprivation and for a variant of the Y1 receptor mediating this peptide’s effect. Peptides 13: 581–587
Akabayashi A, Wahlestedt C, Alexander J, Leibowitz S (1994) Specific inhibition of endogenous neuropeptide Y synthesis in arcuate nucleus by antisense oligonucleotides suppresses feeding behavior and insulin secretion. Brain Res Mol Brain Res 21: 55–61
Dube M, Xu B, Crowley W, Kalra P, Kalra S (1994) Evidence that neuropeptide Y is a physiological signal for normal food intake. Brain Res 646: 341–344
Stanley B, Kyrkouli S, Lampert S, Leibowitz SF (1986) Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides 7: 1189–1192
Raposinho P, Pedrazzini T, White R, Palmiter R, Aubert M (2004) Chronic neuropeptide Y infusion into the lateral ventricle induces sustained feeding and obesity in mice lacking either Npy1r or Npy5r expression. Endocrinology 145: 304–310
Raposinho P, Pierroz D, Broqua P, White R, Pedrazzini T, Aubert M (2001) Chronic administration of neuropeptide Y into the lateral ventricle of C57BL/6J male mice produces an obesity syndrome including hyperphagia, hyperleptinemia, insulin resistance, and hypogonadism. Mol Cell Endocrinol 185: 195–204
Beck B, Stricker Krongrad A, Nicolas J, Burlet C (1992) Chronic and continuous intracerebroventricular infusion of neuropeptide Y in Long Evans rats mimics the feeding behaviour of obese Zucker rats. Int J Obes Relat Metab Disord 16: 295–302
Chamorro S, Della Zuana O, Fauchere J, Feletou M, Galizzi J, Levens N (2002) Appetite suppression based on selective inhibition of NPY receptors. Int J Obes Relat Metab Disord 26: 281–298
Zimany IA, Fathi Z, Poindexter G (1998) Central control of feeding behavior by neuropeptide Y. Curr Pharm Des 4: 349–366
Serradeil Le Gal C, Lafontan M, Raufaste D, Marchand J, Pouzet B, Casellas P, Pascal M, Maffrand J, Le Fur G (2000) Characterization of NPY receptors controlling lipolysis and leptin secretion in human adipocytes. FEBS Lett 475: 150–156
Berglund M, Hipskind P, Gehlert DR (2003) Recent developments in our understanding of the physiological role of PP fold peptide receptor subtypes. Exp Biol Med 228: 217–244
Sainsbury A, Cooney G, Herzog H (2002) Hypothalamic regulation of energy homeostasis. Best Pract Res Clin Endocrinol Metab 16: 623–637
Krysiak R, Okopien B, Belowski D, Madej A, Herman Z (2001) Recent insights into body weight control: from physiology to pathology. J Pept Sci 7: 571–578
Cone R, Cowley M, Butler A, Fan W, Marks D, Low M (2001) The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis. Int J Obes Relat Metab Disord 25: S63–S67
Pinto S, Roseberry A, Liu H, Diano S, Shanabrough M, Cai X, Friedman J, Horvath T (2004) Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science 304: 110–115
Elmquist J (2001) Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin. Physiol Behav 74: 703–708
de Quidt M, Emson P (1986) Distribution of neuropeptide Y like immunoreactivity in the rat central nervous system II. Immunohistochemical analysis. Neuroscience 18: 545–618
Sahu A, Kalra P, Kalra S (1988) Food deprivation and ingestion induced reciprocal changes in neuropeptide Y concentration in the paraventricular nucleus. Peptide 9: 836–886
Calza L, Giardino L, Battistini N, Zanni M, Galetti S, Protopapa F, Velardo A (1989) Increase of neuropeptide Y like immunoreactivity in the pareventricular nucleus of fasting rats. Neuroscience Letters 104: 99–104
Ciofi P, Crowley W, Pillez A, Schmued L, Tramu G, Mazzuca M (1991) Expression of neuropeptide Y precursor immunoreactivity in the hypothalamic dopaminergic tuberoinfundibular system during lactation in rodents. Endocrinology 128: 823–834
Smith M (1993) Lactation alters neuropeptide Y and proopiomelanocortin gene expression in the arcuate nucleus of the rat. Endocrinology 133: 1258–1265
Kalra S, Dube M, Sahu A, Phelps C, Kalra P (1991) Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. PNAS 88: 10931–10935
Stricker Krongrad A, Kozak R, Burlet C, Nicolas J, Beck B (1997) Physiological regulation of hypothalamic neuropeptide Y release in lean and obese rats. Am J Physiol 273: R2112–R2116
Schwartz M, Sipols A, Grubin C, Baskin D (1993) Differential effect of fasting on hypothalamic expression of genes encoding neuropeptide Y, galanin, and glutamic acid decarboxylase. Brain Research Bulletin 31: 361–367
Garcia M, Lopez M, Gualillo O, Seoane L, Dieguez C, Senaris R (2003) Hypothalamic levels of NPY, MCH, and prepro orexin mRNA during pregnancy and lactation in the rat: role of prolactin. FASEB J 17: 1392–1400
Guan X, Yu H, Trumbauer M, Frazier E, Van der Ploeg L, Chen H (1998) Induction of neuropeptide Y expression in dorsomedial hypothalamus of diet induced obese mice. Neuro Report 9: 3415–3419
Guan X, Yu H, Van der Ploeg L (1998) Evidence of altered hypothalamic pro opiomelanocortin/neuropeptide Y mRNA expression in tubby mice. Mol Brain Research 59: 273–279
Kesterson R, Huszar D, Lynch C, Simerly R, Cone R (1997) Induction of neuropeptide Y gene expression in the dorsal medial hypothalamic nucleus in two models of the agouti obesity syndrome. Mol Endocrinol 11: 630–637
Broberger C, Johansen J, Schalling M, Hokfelt T (1997) Hypothalamic neurohistochemistry of the murine anorexia (anx/anx) mutation: altered processing of neuropeptide Y in the arcuate nucleus. J Comp Neuro 387: 124–135
Broberger C, Johansen J, Johansson C, Schalling M, Hokfelt T (1998) The neuropeptide Y/agouti gene related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate treated mice. PNAS 95: 15043–15048
Kanatani A, Ishihara A, Asahi S, Tanaka T, Ozaki S, Ihara M (1996) Potent neuropeptide Y Y1 receptor antagonist, 1229U91: blockade of neuropeptide Y induced and physiological food intake. Endocrinology 137: 3177–3182
Gerald C, Walker M, Criscione L, Gustafson E, Batzl Hartmann C, Smith K, Vaysse P, Durkin M, Laz T, Linemeyer D et al. (1996) A receptor subtype involved in neuropeptide Y induced food intake. Nature 382: 168–171
Marsh D, Hollopeter G, Kafer K, Palmiter R (1998) Role of the Y5 neuropeptide Y receptor in feeding and obesity. Nat Med 4: 718–721
Pedrazzini T, Seydoux J, Kunstner P, Aubert J, Grouzmann E, Beermann F, Brunner H (1998) Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor. Nat Med 46: 722–726
Kanatani A, Mashiko S, Murai N, Sugimoto N, Ito J, Fukuroda T, Fukami T, Morin N, MacNeil D, Van der Ploeg L et al. (2000) Role of Y1 receptor in the regulation of neuropeptide Y mediated feeding: comparison of wild type, Y1 receptor deficient, and Y5 receptor deficient mice. Endocrinology 141: 1011–1016
Sainsbury A, Schwarzer C, Couzens M, Fetissov S, Furtinger S, Jenkins A, Cox H, Sperk G, Hokfelt T, Herzog H (2002) Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice. PNAS 99: 8938–8943
Batterham R, Cowley M, Small C, Herzog H, Cohen M, Dakin C, Wren A, Brynes A, Low M, Ghatei M et al. (2002) Gut hormone PYY(3–36) physiologically inhibits food intake. Nature 418: 650–654
Ueno, N Inui, A Iwamoto, M Kaga, T Asakawa, A Okita, M Fujimiya, M Nakajima, Y Ohmoto, Y Ohnaka et al. (1999) Decreased food intake and body weight in pancreatic polypeptide overexpressing mice. Gastroenterology 117: 1427–1432
Asakawa A, Inui A, Yuzuriha H, Ueno N, Katsuura G, Fujimiya M, Fujino M, Nijima A, Meguid M, Kasuga M (2003) Characterization of the effects of pancreatic polypeptide in the regulation of energy balance. Gastroenterology 124: 1325–1336
Batterham R, Le Roux C, Cohen M, Park A, Ellis S, Patterson M, Frost G, Ghatei M, Bloom S (2003) Pancreatic polypeptide reduces appetite and food intake in humans. J Clin Endocrinol Metab 88: 3989–3992
Sainsbury A, Baldock P, Schwarzer C, Ueno N, Enriquez R, Couzens M, Inui A, Herzog H, Gardiner E (2003) Synergistic effects of Y2 and Y4 receptors on adiposity and bone mass revealed in double knockout mice. Mol Cell Biol 23: 5225–5233
Cheng X, Broberger C, Tong Y, Yongtao X, Ju G, Zhang X, Hokfelt T (1998) Regulation of expression of neuropeptide Y Y1 and Y2 receptors in the arcuate nucleus of fasted rats. Brain Research 792: 89–96
Zammaretti F, Panzica G, Eva C (2001) Fasting, leptin treatment, and glucose administration differently regulate Y1 receptor gene expression in the hypothalamus of transgenic mice. Endocrinology 142: 3774–3782
Oberto A, Mele P, Zammaretti F, Panzica G, Eva C (2003) Evidence of altered neuropeptide Y contents and neuropeptide Y1 receptor gene expression in the hypothalamus of pregnant transgenic mice. Endocrinology 144: 4826–4830
Widdowson P (1997) Regionally selective down regulation of NPY receptor subtypes in the obese Zucker fatty rat, relationship to the Y5 feeding receptor. Brain Research 758: 17–25
Widdowson P, Upton R, Henderson L, Buckingham R, Wilson S, Williams G (1997) Reciprocal regional changes in brain NPY receptor density during dietary restriction and dietary induced obesity in the rat. Brain Research 774: 1–10
Xin X, Huang X (1998) Down regulated NPY receptor subtype 5 mRNA expression in genetically obese mouse brain. Neuro Report 9: 737–741
Huang X, Han M, Storlien L (2003) The level of NPY receptor mRNA expression in diet induced obese and resistant mice. Mol Brain Research 115: 21–28
Small C, Bloom S (2004) Gut hormones as peripheral anti obesity targets. Curr Drug Targets CNS Neurol Disord 3: 379–388
Asakawa A, Inui A, Ueno N, Fujimiya M, Fujino M, Kasuga M (1999) Mouse pancreatic polypeptide modulates food intake, while not influencing anxiety in mice. Peptides 20: 1445–1448
Batterham R, Bloom S (2003) The gut hormone peptide YY regulates appetite. Ann N Y Acad Sci 994: 162–168
Halatchev I, Ellacott K, Fan W, Cone R (2004) Peptide YY3–36 inhibits food intake in mice through a melanocortin 4 receptor independent mechanism. Endocrinology 145: 2585–2590
Nonaka N, Shioda S, Niehoff M, Banks W (2003) Characterization of blood brain barrier permeability to PYY3 36 in the mouse. J Pharmacol Exp Ther 306: 948–953
Kanatani A, Mashiko S, Murai N, Sugimoto N, Ito J, Fukuroda T, Fukami T, Morin N, MacNeil D, Van der Ploeg L et al. (2000) Role of the Y1 receptor in the regulation of neuropeptide Y mediated feeding: comparison of wild type, Y1 receptor deficient, and Y5 receptor deficient mice. Endocrinology 141: 1011–1016
Batterham R, Cohen M, Ellis S, Le Roux C, Withers D, Frost G, Ghatei M, Bloom S (2003) Inhibition of food intake in obese subjects by peptide YY3–36. N Engl J Med 349: 941–948
Herzog H (2003) Neuropeptide Y and energy homeostasis: insights from Y receptor knockout models. Eur J Pharmacol 480: 21–29
Erickson J, Clegg K, Palmiter R (1996) Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 381: 415–421
Segal Lieberman G, Trombly D, Juthani V, Wang X, Maratos Flier E (2003) NPY ablation in C57BL/6 mice leads to mild obesity and to an impaired refeeding response to fasting. Am J Physiol Endocrinol Metab 284: E1131–1139
Qian S, Chen H, Weingarth D, Trumbauer M, Novi D, Guan X, Yu H, Shen Z, Feng Y, Frazier E et al. (2002) Neither agouti related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice. Mol Cell Biol 22: 5027–5035
Hohmann J, Teklemichael D, Weinshenker D, Wynick D, Clifton D, Steiner RA (2004) Obesity and endocrine dysfunction in mice with deletions of both neuropeptide Y and galanin. Mol Cell Biol 24: 2978–2985
Erickson J, Hollopeter G, Palmiter R (1996) Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 274: 1704–1707
Kushi A, Sasai H, Koizumi H, Takeda N, Yokoyama M, Nakamura M (1998) Obesity and mild hyperinsulinemia found in neuropeptide Y Y1 receptor deficient mice. PNAS 95: 15659–15664
Pralong F, Gonzales C, Voirol M, Palmiter R, Brunner H, Gaillard R, Seydoux J, Pedrazzini T (2002) The neuropeptide Y Y1 receptor regulates leptin mediated control of energy homeostasis and reproductive functions. FASEB J 16: 712–714
King P, Williams G, Doods H, Widdowson P (2000) Effect of a selective neuropeptide Y Y(2) receptor antagonist, BIIE0246 on neuropeptide Y release. Eur J Pharmacol 396: R1–R3
Naveilhan P, Hassani H, Canals J, Ekstrand A, Larefalk A, Chhajlani V, Arenas E, Gedda K, Svensson L, Thoren P et al. (1999) Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor. Nat Med 5: 1188–1193
Sainsbury A, Schwarzer C, Couzens M, Herzog H (2002) Y2 receptor deletion attenuates the type 2 diabetic syndrome of ob/ob mice. Diabetes 51: 3420–3427
Sainsbury A, Schwarzer C, Couzens M, Jenkins A, Oakes S, Ormandy C, Herzog H (2002) Y4 receptor knockout rescues fertility in ob/ob mice. Genes Dev 16: 1077–1088
Clark JT, Clark J, Kalra P, Crowley W, Kalra S (1984) Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology 115: 427–429
Parrott R, Heavens R, Baldwin B (1986) Stimulation of feeding in the satiated pig by intracerebroventricular injection of neuropeptide Y. Physiol Behv 36: 523–525
Sakatani N, Inui A, Inoue T, Oya M, Morioka H, Baba S (1987) The role of cholecystokinin octapeptide in the central control of food intake in dog. Peptides 8: 651–656
Miner J, Della-Fera M, Paterson J, Baile C (1989) Lateral cerebroventricular injection of neuropeptide Y stimulates feeding in sheep. Am J Physiol 257: R383–R387
Larsen P, Tang-Christensen M, Stidsen C, Madsen K, Smith M, Cameron J (1999) Activation of central neuropeptide Y Y1 receptors potently stimulates food intake in male rhesus monkeys. J Clin Endocrinol Metab 84: 3781–3791
Zarjevski N, Cusin I, Vettor R, Rohner-Jeanrenaud F, Jeanrenaud B (1993) Chronic intracerebroventricular neuropeptide Y administration to normal rats mimics hormonal and metabolic changes of obesity. Endocrinology 133: 1753–1758
Raposinho P, Pierroz D, Broqua P, White R, Pedrazzini T, Aubert M (2001) Chronic administration of neuropeptide Y into the lateral ventricle of C57BL/6J male mice produces an obesity syndrome including hyperpagia, hyperinsulinemia, insulin resistance and hypogonandism. Mol Cell Endocrinol 185: 195–204
Soll R, Dinger M, Lundell I, Larhammer D, Beck-Sickinger A (2001) Novel analogues of neuropeptide Y with a preference for the Y1 receptor. Eur J Biochem 268: 2828–2837
Mullins D, Kirby D, Hwa J, Guzzi M, Rivier J, Parker E (2001) Identification of potent and selective neuropeptide Y Y1 receptor agonists with orexigenic activity in vivo. Mol Pharmacol 60: 534–540
Parker E, Balasubramaniam A, Guzzi M, Mullins D, Salisbury B, Sheriff S, Witten M, Hwa J (2000) [D Trp34]neuropeptide Y is a potent and selective neuropeptide Y Y5 receptor agonist with dramatic effects on food intake. Peptides 21: 393–399
Cabrele C, Langer M, Bader R, Wieland H, Doods H, Zerbe O, Beck-Sickinger A (2000) The first selective agonist for the neuropeptide YY5 receptor increases food intake in rats. J Biol Chem 275: 36043–36048
Cabrele C, Wieland H, Koglin N, Stidsen C, Beck-Sickinger A (2002) Ala31 Aib32: identification of the key motif for high affinity and selectivity of neuropeptide Y at the Y5 receptor. Biochemistry 41: 8043–8049
Balasubramaniam A, Sheriff S, Zhai W, Chance W (2002) Bis(31/31′)[Cys31,Nva34]NPY(27–36) NH2: a neuropeptide Y (NPY) Y5 receptor selective agonist with a latent stimulatory effect on food intake in rats. A. Peptides 23: 1485–1490
Mashiko S, Ishihara A, Iwaasa H, Sano H, Oda Z, Ito J, Yumoto M, Okawa M, Suzuki J, Fukuroda T et al. (2003) Characterization of neuropeptide Y (NPY) Y5 receptor mediated obesity in mice: chronic intrecerebroventricular infusion of D Trp34NPY. S. Endocrinology 144: 1793–1801
Wyss P, Stricker-Krongrad A, Brunner L, Miller J, Crossthwaite A, Whitebread S, Criscione L (1998) The pharmacology of neuropeptide Y (NPY) receptor mediated feeding in rats characterizes better Y5 than Y1, but not Y2 or Y4 subtypes. Regul Pept 75/76: 363–371
Haynes A, Arch J, Wilson S, McClue S, Buckingham R (1998) Characterization of the neuropeptide Y receptor that mediates feeding in the rat: a role for the Y5 receptor. Regul Pept 75/76: 355–361
Campbell R, Smith M, Allen S, Grayson B, Ffrench-Mullen J, Grove K (2003) Orexin neuron express a functional pancreatic polypeptide Y4 receptor. J Neuroscience 23: 1487–1497
Broberger C, Landry M, Wong H, Walsh J, Hokfelt T (1997) Subtypes Y1 and Y2 of the neuropeptide Y receptor are respectively expressed in pro opiomelanocortin and neuropeptide Y containing neurons of the rat hypothalamic arcuate nucleus. Neuroendocrinol 66: 393–408
Lin S, Boey D, Couzens M, Lee N, Sainsbury A, Herzog H (2005) Compensatory changes in [125I] PYY binding in Y receptor knockout mice suggest the potential existence of further Y receptor(s). Neuropeptides 39: 21–28
Challis B, Pinnock S, Coll A, Carter R, Dickson S, O’Rahilly S (2003) Acute effects of PYY3–36 on food intake and hypothalamic neuropeptide expression in the mouse. Biochem Biophys Res Comm 311: 915–919
Koda S et al. (2005) The role of the vagal nerve in peripheral PYY3-36 induced feeding reduction in rats. Endocrinology 146: 2369–2375
Sato N, Takahashi T, Shibata T, Haga Y, Sakuraba A, Hirose M, Sato M, Nonoshita K, Koike Y, Kitazawa H et al. (2003) Design and synthesis of the potent, orally available, brain penetrable arylpyrazole class of neuropeptide Y5 receptor antagonists. J Med Chem 246: 666–669
Kanatani A, Ishihara A, Iwaasa H, Nakamura K, Okamoto O, Hidaka M, Ito J, Fukuroda T, MacNeil D, Van der Ploeg L et al. (2000) L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist. Biochem Biophys Res Commun 272: 169–173
Kanatani A, Kanno T, Ishihara A, Hata M, Sakuraba A, Tanaka T, Tsuchiya Y, Mase T, Fukuroda T, Fukami T et al. (1999) The novel neuropeptide Y Y(1) receptor antagonist J 104870: a potent feeding suppressant with oral bioavailability. Biochem Biophys Res Commun 266: 88–91
Kanatani A, Hata M, Mashiko S, Ishihara A, Okamoto O, Haga Y, Ohe T, Kanno T, Murai N, Ishii Y et al. (2001) A typical Y1 receptor regulates feeding behaviors: effects of a potent and selective Y1 antagonist, J-115814. Mol Pharmacol 3: 501–505
Ishihara A, Kanatani A, Okada M, Hidaka M, Tanaka T, Mashiko S, Gomori A, Kanno T, Hata M, Kanesaka M et al. (2002) Blockade of body weight gain and plasma corticosterone levels in Zucker fatty rats using an orally active neuropeptide Y Y1 antagonist. Br J Pharmacol 1363: 341–346
Turnbull A, Ellershaw L, Masters D, Birtles S, Boyer S, Carroll D, Clarkson P, Loxham S, McAulay P, Teague J et al. (2002) Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats. Diabetes 51: 2441–2449
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Birkhäuser Verlag/Switzerland
About this chapter
Cite this chapter
MacNeil, D.J., Kanatani, A. (2006). NPY and energy homeostasis: an opportunity for novel anti-obesity therapies. In: Zukowska, Z., Feuerstein, G.Z. (eds) NPY Family of Peptides in Neurobiology, Cardiovascular and Metabolic Disorders: from Genes to Therapeutics. Experientia Supplementum, vol 95. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7417-9_11
Download citation
DOI: https://doi.org/10.1007/3-7643-7417-9_11
Publisher Name: Birkhäuser Basel
Print ISBN: 978-3-7643-7155-5
Online ISBN: 978-3-7643-7417-4
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)