Immune response in human pathology: hypersensitivity and autoimmunity
The immune system is a complex network and inadvertent immunological reactivity can result in HYPERSENSITIVITY or autoimmunity. Nearly every chemical can induce HYPERSENSITIVITY reactions which can affect nearly every organ or tissue of the body. One organ or tissue, however, is often a predominant target. Anaphylactic shock, skin reactions, and cytopenias are the most frequent reactions. HYPERSENSITIVITY reactions can be either immunemediated or non-immune-mediated (pseudoallergy). A number of different mechanisms are involved and risk factors can serve as triggers. Autoimmunity is still a mystery even though autoimmune diseases are relatively common. Spontaneous autoimmune diseases as well as drug- and chemical-induced autoimmune reactions are divided into systemic and organ-specific. Our current understanding of the mechanisms involved in these adverse reactions is very limited.
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- Descotes J (ed.) (2004) Immunotoxicity of Drugs and Chemicals: An Experimental and Clinical Approach. Vol. 1: Principles and Methods of Immunotoxicology. Elsevier, AmsterdamGoogle Scholar
- Holgate ST, Church MK, Lichtenstein LM (2000) Allergy (2nd Edition). Mosby, LondonGoogle Scholar
- Gorski A, Krotkiewski H, Zimecki M (2001) Autoimmunity. Kluwer Academic Publishers, Dordrecht, BostonGoogle Scholar
- 1.Descotes J (2004) Health consequences of immunotoxic effects. In: Descotes J (ed): Immunotoxicity of Drugs and Chemicals, 3rd edition. Elsevier, Amsterdam, 55–126Google Scholar
- 5.Klein JS, Yocum MN (1995) Underreporting of anaphylaxis in a community emergency room. J Clin Allergy Immunol 95: 637–638Google Scholar
- 6.Gruchalla RS (2003) Drug allergy. J Allergy Clin Immunol 111(Suppl): 548–559Google Scholar
- 9.Svensson CR, Cowen EW, Gaspari AA (2000) Cutaneous drug reactions. Pharmacol Rev 53: 357–379Google Scholar
- 19.Liu ZX, Kaplowitz N (2002) Immune-mediated drug-induced liver disease. Clin Liver Dis 6: 467–486Google Scholar
- 23.The International Collaborative Study of Severe Anaphylaxis (1998) An epidemiological study of severe anaphylactic and anaphylactoid reactions among hospital patients: methods and overall risks. Epidemiology 9: 141–146Google Scholar
- 32.Agostoni A, Cicardi M, Cugno M, Zingale LC, Gioffre D, Nussberger J (1999) Angioedema due to angiotensin-converting enzyme inhibitors. Immunopharmacology 4: 21–25Google Scholar
- 36.Vial T, Chevrel G, Descotes J (2000) Drugs acting on the immune system. In: MNG Dukes, JK Aronson (eds): Meyler’s Side-Effects of Drugs, 14th edition. Elsevier Sciences, Amsterdam, 1246–1337Google Scholar