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Genes in Populations: Backward in Time

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11.11 Summary

In this chapter we have turned the Wright-Fisher model of gene dynamics on its head. Given a sample of n genes, their lineages coalesce into common ancestors as we move backward in time. If we trace back the gene genealogies until the most recent common ancestor of the entire sample, this sample genealogy is called the coalescent. Coalescent theory allows the derivation of important evolutionary quantities such as the number of segregating sites expected under neutrality. In addition, the coalescent is routinely used as a very efficient tool for simulating gene samples under a diverse range of evolutionary scenarios, including recombination and selection.

Keywords

  • Recent Common Ancestor
  • Much Recent Common Ancestor
  • Coalescence Time
  • Gene Genealogy
  • Ancestral Recombination Graph

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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  • DOI: 10.1007/3-7643-7387-3_11
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11.12 Further Reading

  1. J. Hein, M. Shierup, and C. Wiuf. Gene Genealogies, Variation and Evolution: A primer in coalescent theory. Oxford University Press, Oxford, 2004.

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  2. R. R. Hudson. Gene genealogies and the coalescent process. Oxford Surveys in Evolutionary Biology, 7:1–44, 1990.

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  3. M. Nordborg. Coalescent theory. In D. J. Balding, M. Bishop, and C. Cannings, editors, Handbook of Statistical Genetics, chapter 7, pages 178–212. Wiley, New York, 2001.

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© 2006 Birkhäuser Verlag

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(2006). Genes in Populations: Backward in Time. In: Introduction to Computational Biology. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7387-3_11

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