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Viral carcinogenesis and genomic instability

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Book cover Cancer: Cell Structures, Carcinogens and Genomic Instability

Part of the book series: Experientia Supplementum ((EXS,volume 96))

Abstract

Oncogenes encoded by human tumor viruses play integral roles in the viral conquest of the host cell by subverting crucial and relatively non-redundant regulatory circuits that regulate cellular proliferation, differentiation, apoptosis and life span. Human tumor virus oncoproteins can also disrupt pathways that are necessary for the maintenance of the integrity of host cellular genome. Some viral oncoproteins act as powerful mutator genes and their expression dramatically increases the incidence of host cell mutations with every round of cell division. Others subvert cellular safeguard mechanisms intended to eliminate cells that have acquired abnormalities that interfere with normal cell division. Viruses that encode such activities can contribute to initiation as well as progression of human cancers.

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Authors and Affiliations

  1. The Channing Laboratory, Brigham and Women’s Hospital, 181 Longwood Avenue, Boston, MA, 02115, USA

    Karl Münger, Hiroyuki Hayakawa, Christine L. Nguyen & Nadja V. Melquiot

  2. Molecular Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, 15213, USA

    Anette Duensing & Stefan Duensing

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  1. Karl Münger
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  2. Hiroyuki Hayakawa
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  5. Anette Duensing
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  6. Stefan Duensing
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© 2006 Birkhäuser Verlag/Switzerland

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Münger, K., Hayakawa, H., Nguyen, C.L., Melquiot, N.V., Duensing, A., Duensing, S. (2006). Viral carcinogenesis and genomic instability. In: Cancer: Cell Structures, Carcinogens and Genomic Instability. Experientia Supplementum, vol 96. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7378-4_8

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