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Clinical efficacy of St. John’s Wort in psychiatric disorders other than depression

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St. John’s Wort and its Active Principles in Depression and Anxiety

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References

  1. Harrison P (1998) Herbal medicine takes root in Germany. CMAJ 158: 637–639

    PubMed  Google Scholar 

  2. Kasper S, Dienel A (2002) Cluster analysis of symptoms during antidepressant treatment with Hypericum extract in mildly to moderately depressed out-patients. A meta-analysis of data from three randomised, placebo-controlled trials. Psychopharmacology 164: 301–308

    Article  PubMed  Google Scholar 

  3. Linde K, Ramirez G, Mulrow CD, Pauls A, Weidenhammer W, Mechart D (1996) St. John’s Wort for depression — an overview and meta-analysis of randomised controlled clinical trials. BMJ 313: 253–258

    PubMed  Google Scholar 

  4. Volz HP (1997) Controlled clinical trials of Hypericum extracts in depressed patients — an overview. Pharmacopsychiatry 30: 102–107

    PubMed  Google Scholar 

  5. Kim HL, Streltzer J, Goebert D (1999) St. John’s Wort for depression — a meta-analysis of well-defined clinical trials. J Nerv Ment Dis 187: 532–539

    Article  PubMed  Google Scholar 

  6. Kasper S, Trautmann-Sponsel RD (2001) St. John’s Wort extract: an effective and well-tolerated antidepressant. Primary Care Psychiatry 7: 39–42

    Article  Google Scholar 

  7. Kasper S (2004) Clinical efficacy in depression. In: WE Müller (ed.): St. John’s Wort and its active principles in depression and anxiety. Birkhäuser, Basel; 123–131

    Google Scholar 

  8. Beijamini V, Andreatini R (2003a) Effects of Hypericum perforatum and paroxetine on rat performance in the elevated T-maze. Pharmacol Res 48: 199–207

    Article  PubMed  Google Scholar 

  9. Beijamini V, Andreatini R (2003b) Effects of Hypericum perforatum and paroxetine in the mouse defense test battery. Pharmacol Biochem Behav 74: 1015–1024

    Article  PubMed  Google Scholar 

  10. Flausino OA Jr, Zangrossi H Jr, Salgado JV, Viana MV (2002) Effects of acute and chronic treatment with Hypericum perforatum L. (LI 160) on different anxiety-related responses in rats. Pharmacol Biochem Behav 71: 251–257

    Article  PubMed  Google Scholar 

  11. Chatterjee SS (2004) Efficacy in behavioural models of anxiety and cognition. In: WE Müller (ed.): St. John’s Wort and its active principles in depression and anxiety. Birkhäuser, Basel; 85–97

    Google Scholar 

  12. Zanoli P, Rivasi M, Baraldi C, Baraldi M (2002) Pharmacological activity of hyperforin acetate in rats. Behav Pharmacol 13: 645–651

    PubMed  Google Scholar 

  13. Sommer H, Harrer G (1994) Placebo-controlled double-blind study examining the effectiveness of a Hypericum preparation in 105 mildly depressed patients. J Geriatr Psychiatry Neurol 7: S9–S11

    PubMed  Google Scholar 

  14. Hübner WD, Lande S, Podzuweit H (1994) Hypericum treatment of mild depressions with somatic symptoms. J Geriatr Psychiatr Neurol 7(Suppl 1): S12–S14

    Google Scholar 

  15. Volz HP, Murck H, Kasper S, Möller HJ (2002) St. John’s Wort extract (LI 160) in somatoform disorders: results of a placebo-controlled trial. Psychopharmacology 164: 294–300

    Article  PubMed  Google Scholar 

  16. Bass C, Peveler R, House A (2001) Somatoform disorders: severe psychiatric illnesses neglected by psychiatrists. Br J Psychiatry 179: 11–14

    Article  PubMed  Google Scholar 

  17. Müller T, Mannel M, Murck H, Rahlfs VW (2004) Treatment of somatoform disorders with St. John’s Wort — a randomised, double-blind and placebo-controlled trial. Psychosom Med 66: 538–547

    PubMed  Google Scholar 

  18. Stevinson C, Ernst E (2000) A pilot study of Hypericum perforatum for the treatment of premenstrual syndrome. Br J Obstet Gynaecol 107: 870–876

    Google Scholar 

  19. Grube B, Walper A, Wheatley D (1999) St. John’s Wort extract: Efficacy for menopausal symptoms of psychological origin. Advances in Therapy 16: 177–1186

    PubMed  Google Scholar 

  20. Stevinson C, Dixon M, Ernst E (1998) Hypericum for fatigue — a pilot study. Phytomedicine 5: 443–447

    Google Scholar 

  21. Murck H (2003) Atypical depression and spectrum disorder — neurobiology and treatment. Acta Neuropsychiatrica 15: 227–241

    Google Scholar 

  22. Murck H, Fava M, Alpert J, Nierenberg AA, Mischoulon D, Otto MW, Zajecka J, Mannel M, Rosenbaum JF (2004) Hypericum extract in patients with MDD and reversed vegetative signs: re-analysis from data of a double-blind, randomized trial of Hypericum extract, fluoxetine and placebo. Int J Neuropsychopharmacol sept. 30, 1–7 (Epub ahead of print)

    Google Scholar 

  23. Wheatley D (1999) Hypericum in seasonal affective disorder (SAD). Curr Med Res Opinion 15: 33–37

    Google Scholar 

  24. Kasper S (1997) Treatment of seasonal affective disorder (SAD) with Hypericum extract. Pharmacopsychiatry 30(Suppl 2): 89–93

    PubMed  Google Scholar 

  25. Martinez B, Kasper S, Ruhrmann S, Möller HJ (1994) Hypericum in the treatment of seasonal affective disorders. J Geriatr Psychiatry Neurol 7,Suppl. 1: S29–S33

    PubMed  Google Scholar 

  26. Taylor LH, Kobak KA (2000) An open-label trial of St. John’s Wort (Hypericum perforatum) in obsessive-compulsive disorder. J Clin Psychiatry 61: 575–578

    PubMed  Google Scholar 

  27. Davidson JRT, Connor KM (2001) St. John’s Wort in generalized anxiety disorder: Three case reports. J Clin Psychopharmacol 21: 635–636

    PubMed  Google Scholar 

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Volz, HP. (2005). Clinical efficacy of St. John’s Wort in psychiatric disorders other than depression. In: Müller, W.E. (eds) St. John’s Wort and its Active Principles in Depression and Anxiety. Milestones in Drug Therapy MDT. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7338-5_11

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