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Drugs for Relapse Prevention of Alcoholism pp 117–124Cite as

Opioidergic compounds: preclinical data

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References

  1. Olive MF, Koenig HN, Nannini MA, Hodge CW (2001) Stimulation of endorphin neurotransmission in the nucleus accumbens by ethanol, cocaine, and amphetamine. J Neurosci 21: 184RC

    Google Scholar 

  2. de Waele J-P, Papachristou DN, Gianoulakis C (1992) The alcohol-preferring C57BL/6 mice present an enhanced sensitivity of the hypothalamic β-endorphin system to ethanol than the alcohol-avoiding DBA/2 mice. J Pharmacol Exp Ther 261: 788–794

    PubMed  Google Scholar 

  3. Gianoulakis C, de Waele J-P, Kiianmaa K (1992) Differences in the brain and pituitary â-endorphin system between the alcohol-preferring AA and alcohol-avoiding ANA rats. Alcohol Clin Exp Res 16: 453–459

    PubMed  CAS  Google Scholar 

  4. Nylander I, Hyytiä P, Forsander O, Terenius L (1994) Differences between alcohol-preferring (AA) and alcohol-avoiding (ANA) rats in the prodynorphin and proenkephalin systems. Alcohol Clin Exp Res 18: 1272–1279

    PubMed  CAS  Google Scholar 

  5. Chen Y, Mestek A, Liu J, Hurley JA, Yu L (1993) Molecular cloning and functional expression of a mu-opioid receptor from rat brain. Mol Pharmacol 44: 8–12

    PubMed  CAS  Google Scholar 

  6. Evans CJ, Keith DE, Jr, Morrison H, Magendzo K, Edwards RH (1992) Cloning of a delta opioid receptor by functional expression. Science 258: 1952–1955

    PubMed  CAS  Google Scholar 

  7. Kieffer BL, Befort K, Gaveriaux-Ruff C, Hirth CG (1992) The delta-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization. Proc Natl Acad Sci USA 89: 12048-12052

    Google Scholar 

  8. Minami M, Toya T, Katao Y, Maekawa K, Nakamura S, Onogi T, Kaneko S, Satoh M (1993) Cloning and expression of a cDNA for the rat kappa-opioid receptor. FEBS Lett 329: 291–295

    Article  PubMed  CAS  Google Scholar 

  9. Akil H, Owens C, Gutstein H, Taylor L, Curran E, Watson S (1998) Endogenous opioids: overview and current issues. Drug Alcohol Depend 51: 127–140

    PubMed  CAS  Google Scholar 

  10. Chang KJ, Cooper BR, Hazum E, Cuatrecasas P (1979) Multiple opiate receptors: different regional distribution in the brain and differential binding of opiates and opioid peptides. Mol Pharmacol 16: 91–104

    PubMed  CAS  Google Scholar 

  11. Chang KJ, Cuatrecasas P (1981) Heterogeneity and properties of opiate receptors. Fed Proc 40: 2729–2734

    PubMed  CAS  Google Scholar 

  12. Childers SR, Creese I, Snowman AM, Synder SH (1979) Opiate receptor binding affected differentially by opiates and opioid peptides. Eur J Pharmacol 55: 11–18

    Article  PubMed  CAS  Google Scholar 

  13. Katner SN, Magalong JG, Weiss F (1999) Reinstatement of alcohol-seeking behavior by drug-associated discriminative stimuli after prolonged extinction in the rat. Neuropsychopharmacology 20: 471–479

    Article  PubMed  CAS  Google Scholar 

  14. Ciccocioppo R, Martin-Fardon R, Weiss F (2002) Effect of selective blockade of μ1 or δ opioid receptors on reinstatement of alcohol-seeking behavior by drug-associated stimuli in rats. Neuropsychopharmacology 27: 391–399

    Article  PubMed  CAS  Google Scholar 

  15. Krishnan-Sarin S, Wand GS, Li XW, Portoghese PS, Froehlich JC (1998) Effect of mu opioid receptor blockade on alcohol intake in rats bred for high alcohol drinking. Pharmacol Biochem Behav 59: 627–635

    Article  PubMed  CAS  Google Scholar 

  16. Stromberg MF, Casale M, Volpicelli L, Volpicelli JR, O’Brien CP (1998) A comparison of the effects of the opioid antagonists naltrexone, naltrindole, and beta-funaltrexamine on ethanol consumption in the rat. Alcohol 15: 281–289

    Article  PubMed  CAS  Google Scholar 

  17. Hyytiä P, Kiianmaa K (2001) Suppression of ethanol responding by centrally administered CTOP and naltrindole in AA and Wistar rats. Alcohol Clin Exp Res 25: 25–33

    PubMed  Google Scholar 

  18. Kim SG, Stromberg MF, Kim MJ, Volpicelli JR, Park JM (2000) The effect of antagonists selective for mu-and delta-opioid receptor subtypes on alcohol consumption in C57BL/6 mice. Alcohol 22: 85–90

    Article  PubMed  CAS  Google Scholar 

  19. Hyytiä P (1993) Involvement of mu-opioid receptors in alcohol drinking by alcohol-preferring AA rats. Pharmacol Biochem Behav 45: 697–701

    PubMed  Google Scholar 

  20. Honkanen A, Vilamo L, Wegelius K, Sarviharju M, Hyytiä P, Korpi ER (1996) Alcohol drinking is reduced by a μ1-but not by a δ-opioid receptor antagonist in alcohol-preferring rats. Eur J Pharmacol 304: 7–13

    Article  PubMed  CAS  Google Scholar 

  21. Mhatre M, Holloway F (2003) Micro1-opioid antagonist naloxonazine alters ethanol discrimination and consumption. Alcohol 29: 109–116

    Article  PubMed  CAS  Google Scholar 

  22. Froehlich JC, Zweifel M, Harts J, Lumeng L, Li TK (1991) Importance of delta opioid receptors in maintaining high alcohol drinking. Psychopharmacology (Berl) 103: 467–472

    CAS  Google Scholar 

  23. Krishnan-Sarin S, Jing SL, Kurtz DL, Zweifel M, Portoghese PS, Li TK, Froehlich JC (1995) The delta opioid receptor antagonist naltrindole attenuates both alcohol and saccharin intake in rats selectively bred for alcohol preference. Psychopharmacology (Berl) 120: 177–185

    CAS  Google Scholar 

  24. Franck J, Lindholm S, Raaschou P (1998) Modulation of volitional ethanol intake in the rat by central delta-opioid receptors. Alcohol Clin Exp Res 22: 1185–1189

    PubMed  CAS  Google Scholar 

  25. Le AD, Poulos CX, Quan B, Chow S (1993) The effects of selective blockade of delta and mu opiate receptors on ethanol consumption by C57BL/6 mice in a restricted access paradigm. Brain Res 630: 330–332

    PubMed  CAS  Google Scholar 

  26. Williams KL, Woods JH (1998) Oral ethanol-reinforced responding in rhesus monkeys: effects of opioid antagonists selective for the mu-, kappa-, or delta-receptor. Alcohol Clin Exp Res 22: 1634–1639

    PubMed  CAS  Google Scholar 

  27. Middaugh LD, Kelley BM, Groseclose CH, Cuison ER Jr (2000) Delta-opioid and 5-HT3 receptor antagonist effects on ethanol reward and discrimination in C57BL/6 mice. Pharmacol Biochem Behav 65: 145–154

    Article  PubMed  CAS  Google Scholar 

  28. Negri L, Potenza RL, Corsi R, Melchiorri P (1991) Evidence for two subtypes of delta opioid receptors in rat brain. Eur J Pharmacol 196: 335–336

    Article  PubMed  CAS  Google Scholar 

  29. Sofuoglu M, Portoghese PS, Takemori AE (1991) Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes. J Pharmacol Exp Ther 257: 676–680

    PubMed  CAS  Google Scholar 

  30. Krishnan-Sarin S, Portoghese PS, Li TK, Froehlich JC (1995) The delta 2-opioid receptor antagonist naltriben selectively attenuates alcohol intake in rats bred for alcohol preference. Pharmacol Biochem Behav 52: 153–159

    Article  PubMed  CAS  Google Scholar 

  31. June HL, McCane SR, Zink RW, Portoghese PS, Li TK, Froehlich JC (1999) The delta 2-opioid receptor antagonist naltriben reduces motivated responding for ethanol. Psychopharmacology (Berl) 147: 81–89

    CAS  Google Scholar 

  32. O’Brien CP, Childress AR, Ehrman R, Robbins SJ (1998) Conditioning factors in drug abuse: can they explain compulsion? J Psychopharmacol 12: 15–22

    PubMed  CAS  Google Scholar 

  33. See RE (2002) Neural substrates of conditioned-cued relapse to drug-seeking behavior. Pharmacol Biochem Behav 71: 517–529

    Article  PubMed  CAS  Google Scholar 

  34. Cunningham CL, Henderson CM, Bormann NM (1998) Extinction of ethanol-induced condiditioned place preference and conditioned place aversion: effects of naloxone. Psychopharmacology (Berl) 139: 62–70

    CAS  Google Scholar 

  35. Kuzmin A, Sandin J, Terenius L, Ogren SO (2003) Acquisition, expression, and reinstatement of ethanol-induced conditioned place preference in mice: effects of opioid receptor-like 1 receptor agonists and naloxone. J Pharmacol Exp Ther 304: 310–318

    Article  PubMed  CAS  Google Scholar 

  36. Matsuzawa S, Suzuki T, Misawa M, Nagase H (1998) Involvement of mu-and delta-opioid receptors in the ethanol-associated place preference in rats exposed to foot shock stress. Brain Res 803: 169–177

    Article  PubMed  CAS  Google Scholar 

  37. Matsuzawa S, Suzuki T, Misawa M, Nagase H (1999) Different roles of mu-, delta-and kappaopioid receptors in ethanol-associated place preference in rats exposed to conditioned fear stress. Eur J Pharmacol 368: 9–16

    Article  PubMed  CAS  Google Scholar 

  38. Cooper SJ (1983) Benzodiazepine-opiate antagonist interactions in relation to feeding and drinking behavior. Life Sci 32: 1043–1051

    PubMed  CAS  Google Scholar 

  39. Heyser CJ, Roberts AJ, Schulteis G, Koob GF (1999) Central administration of an opiate antagonist decreases oral ethanol self-administration in rats. Alcohol Clin Exp Res 23: 1468–1476

    PubMed  CAS  Google Scholar 

  40. Benjamin D, Grant ER, Pohorecky LA (1993) Naltrexone reverses ethanol-induced dopamine release in the nucleus accumbens in awake, freely moving rats. Brain Res 621: 137–140

    Article  PubMed  CAS  Google Scholar 

  41. Acquas E, Meloni M, Di Chiara G (1993) Blockade of delta-opioid receptors in the nucleus accumbens prevents ethanol-induced stimulation of dopamine release. Eur J Pharmacol 230: 239–241

    Article  PubMed  CAS  Google Scholar 

  42. Gonzales RA, Weiss F (1998) Suppression of ethanol-reinforced behavior by naltrexone is associated with attenuation of the ethanol-induced increase in dialysate dopamine levels in the nucleus accumbens. J Neurosci 18: 10663–10671

    PubMed  CAS  Google Scholar 

  43. Weiss F, Lorang MT, Bloom FE, Koob GF (1993) Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants. J Pharmacol Exp Ther 267: 250–258

    PubMed  CAS  Google Scholar 

  44. Katner SN, Weiss F (1999) Ethanol-associated olfactory stimuli reinstate ethanol-seeking behavior after extinction and modify extracellular dopamine levels in the nucleus accumbens. Alcohol Clin Exp Res 23: 1751–1760

    PubMed  CAS  Google Scholar 

  45. Devine DP, Leone P, Pocock D, Wise RA (1993) Differential involvement of ventral tegmental mu, delta and kappa opioid receptors in modulation of basal mesolimbic dopamine release: in vivo microdialysis study. J Pharmacol Exp Ther 266: 1236–1246

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Mental Health and Alcohol Research, National Public Health Institute, POB 33, FI-00251, Helsinki, Finland

    Petri Hyytiä

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  1. Petri Hyytiä
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Editor information

Editors and Affiliations

  1. Abteilung für Psychopharmakologie, Universit ät Heidelberg, J5, Zentralinstitut für Seelische Gesundheit, 68159, Mannheim, Germany

    Rainer Spanagel

  2. Klinik für Abhängiges Verhalten und Suchtmedizin, J5, Zentralinstitut für Seelische Gesundheit, 68159, Mannheim, Germany

    Karl F. Mann

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© 2005 Birkhäuser Verlag/Switzerland

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Hyytiä, P. (2005). Opioidergic compounds: preclinical data. In: Spanagel, R., Mann, K.F. (eds) Drugs for Relapse Prevention of Alcoholism. Milestones in Drug Therapy MDT. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7305-9_11

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