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Micro Total Analysis Systems: Microfluidic Aspects, Integration Concept and Applications

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Microsystem Technology in Chemistry and Life Science

Part of the book series: Topics in Current Chemistry ((4143,volume 194))

Abstract

In this contribution three aspects of miniaturized total analysis systems (µTAS) are described and discussed in detail. First, an overview of microfabricated components for fluid handling is given. A description of the importance of sampling- and fluid-handling techniques is followed by details of microvalves, micropumps and micro flowchannels. Secondly, the problems associated with system integration are discussed. As a solution for the realization of microfluidic- and micro analysis systems, the concept of a planar mixed circuit board (MCB) as a platform for the integration of different components is described. In addition, the design, modeling and simulation, and realization of several components in the form of standard modules for integration on a MCB is described. As an illustration of the potential of this approach, the realization of a µTAS demonstrator for the optical detection of the pH change of a pH indicator, is presented. Finally, a number of different applications of µTAS are described, such as on-line process monitoring, environmental monitoring, biomedical and space applications and DNA-analysis.

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6 References

  1. van den Berg A, Bergveld P (1996) Anal Meth Instr Special Issue 1996:9

    Google Scholar 

  2. Göpel H (1991) (ed) Sensors, A comprehensive survey, 2, VCH-Verlag, Weinheim, Germany

    Google Scholar 

  3. Gravesen P, Branebjerg J, Jensen OS (1993) J Micromech Microeng 3:168

    Article  CAS  Google Scholar 

  4. Elwenspoek M, Lammerink TSJ, Miyake R, Fluitman JHJ (1994) J Micromech Microeng 4:227

    Article  CAS  Google Scholar 

  5. van den Berg A, van der Schoot BH, van den Vlekkert HH (1991) Ion sensitive field effect transistors. In: Sensors — A comprehensive book series in eight volumes, vol 2, chap 10.2, VCH, Weinheim, Germany

    Google Scholar 

  6. Manz A, Graber N, Widmer HM (1990) Sens Actuators, B1:244

    CAS  Google Scholar 

  7. van der Schoot BH, Jeanneret S, van den Berg A, de Rooij NF (1993) Anal Meth Instrumentation 1(1):38

    Google Scholar 

  8. Bruns MW (1992) Proc. IEEE Int Conf Industrial Electronics Control Instrumentation 3:1640

    Article  Google Scholar 

  9. van Lintel HTC, van de Pol FCM, Bouwstra S (1988) Sens Actuators 15:153

    Article  Google Scholar 

  10. van der Linden WE (1987) Trends Anal Chem 6:37

    Article  Google Scholar 

  11. van Steenkiste F, Grünkorn H, Claesen L, Baert K, Hermans L, DeBruyker D, de Cooman M, Spiering V, van den Berg A, van der Schoot BH, Arquint P, Born R, Schumann K (1996) Anal Meth Instr Spec. Issue µTAS ’96:138

    Google Scholar 

  12. van Rijn CJM, Elwenspoek MC (1995) Proc MEMS’ 95, Amsterdam, The Netherlands, 83

    Google Scholar 

  13. Miyake R, Lammerink TSJ, Elwenpoek MC, Fluitman JHJ (1993) Proc MEMS’ 93, Fort Lauderdale, (FA), USA

    Google Scholar 

  14. Robinson TE, Justice JB (1991) Microdialysis in neurosciences, Elsevier, Amsterdam, The Netherlands

    Google Scholar 

  15. Laurell T, Rosengren L, Drott J (1994) In: van den Berg A, Bergveld P (eds), Micro total analysis systems, Kluwer, Dordrecht, The Netherlands, p 227

    Google Scholar 

  16. Künnecke W, Bilitewski U (1994) A novel sampling technique for total analysis systems In: van den Berg A, Bergveld P (eds) Micro total analysis systems, Kluwer, Dordrecht, The Netherlands, p 223

    Google Scholar 

  17. Kaartinen N (1996) Proc MEMS’ 96, San Diego, (CA), USA, 395

    Google Scholar 

  18. Schomburg WK, Vollmer J, Büstgens B, Fahrenberg J, Hein H, Menz W (1994) J Micromech Microeng 3:216

    Article  Google Scholar 

  19. Smits JG (1990) Sens Actuators, A21–23:203

    Article  Google Scholar 

  20. Lammerink TSJ, Elwenspoek M, Fluitman JHJ (1993) Proc MEMS’ 93, Fort Lauderdale, FA, USA, 254

    Google Scholar 

  21. van de Pol FCM, van Lintel HTG, Elwenspoek M, Fluitman JHJ (1990) Sens Actuators A21–A23:198

    Google Scholar 

  22. van der Schoot BH, Jeanneret S, van den Berg A, de Rooij NF (1992) Sens Actuators B6:57

    Google Scholar 

  23. Gass V, van der Schoot BH, Jeanneret S, de Rooij NF (1993) Proc MME’ 93, Neuchatel, Switzerland, 177

    Google Scholar 

  24. Shoji S, Esashi M, van der Schoot BH, de Rooij NJ (1992) Sens Actuators, A32:335

    Article  CAS  Google Scholar 

  25. Zengerle R, Uhlrich J, Kluge S, Richter M, Richter A (1995) Sens Actuators A50:81

    Article  CAS  Google Scholar 

  26. 20SIM, Commercially available modeling and simulation package developed at the University of Twente, Control laboratory, Faculty of Electrical Engineering, Enschede, the Netherlands

    Google Scholar 

  27. Zengerle R, Richter A, Sandmaier H (1990) Proc MEMS ’92:19

    Google Scholar 

  28. Richter A, Plettner A, Hoffmann KA, Sandmaier H (1991) Sens Actuators A29:159

    Article  CAS  Google Scholar 

  29. Richter A, Plettner A, Hofmann KA, Sandmayer H (1991) Proc MEMS ’91:271

    Google Scholar 

  30. Bart SF, Lee S, Tavrow 1 (1990) Mehregany M, Lang J (1990) Sens Actuators, A21–23:193

    Article  Google Scholar 

  31. Fuhr G, Hagedorn R, Müller T, Benecke W, Wagner B (1992) Proc MEMS ’92:25

    Google Scholar 

  32. Harrison DJ, Fluri K, Seiler K, Fan Z, Effenhauser CS, Manz A (1993) Science 261:895

    Article  CAS  Google Scholar 

  33. Jakobson SC, Hergenroder R, Koutny LB, Ramsey JM (1994) Anal Chem 66:1114.

    Article  Google Scholar 

  34. Manz A, Harrison DJ, Verpoorte EMJ, Lüdi H, Widmer HM (1992) J Chromatogr 593:253

    Article  CAS  Google Scholar 

  35. Stemme E, Stemme G (1993) Sens Actuators A39:159

    Article  Google Scholar 

  36. Olsson A, Enoksson P, Stemme G, Stemme E (1995) Proc Transducers’ 95, Stockholm, Sweden, 291

    Google Scholar 

  37. Jansen HV, de Boer M, Legtenberg R, Elwenspoek M (1995) J Micromech Microeng 9:115

    Article  Google Scholar 

  38. van der Schoot BH, Verpoorte EMJ, Jeanneret S, Manz A, Verpoorte NF (1994) Microsystems for analysis in flowing solutions. In: Micro total analysis systems, Kluwer, Dordrecht, The Netherlands, p 181

    Google Scholar 

  39. van der Schoot BH, Jeanneret S, van den Berg A, de Rooij NF (1992) Sens Actuators, B6:57

    Google Scholar 

  40. Fettinger JC, Manz A, Lüdi H, Widmer HM (1993) Sens Actuators, B20:19

    Google Scholar 

  41. Arquint Ph, van den Berg A, van der Schoot BH, de Rooij NF, Bühler H, Morf WE (1993) Sens Actuators, B13–14:340

    Google Scholar 

  42. Lammerink TSJ, Tas NR, Berenschot JW, Elwenspoek MC, Fluitman JHJ (1995) Proc MEMS’ 95, Amsterdam, The Netherlands, 13

    Google Scholar 

  43. Lammerink TSJ, Spiering VL, Elwenspoek M, Fluitman JHJ, van den Berg A (1996) Proc MEMS, San Diego, USA, 389

    Google Scholar 

  44. van der Schoot BH, Verpoorte EMJ, Jeanneret S, Manz A, de Rooij NF (1994) Micro total analysis systems, van den Berg A, Bergveld P (eds.), Kluwer Academic Publishers, Dordrecht, The Netherlands, 181

    Google Scholar 

  45. van der Schoot BH, Jeanneret S, van den Berg A, de Rooij NF (1993) Anal Meth Instr 1(1):38

    Google Scholar 

  46. Gumbrecht W, Abraham-Fuchs K (1996) Proc Eurosens X, Leuven, Belgium, 777

    Google Scholar 

  47. Gumbrecht W, Peters D, Scheller W, Erhardt W, Henke J, Steil J, Sykora U (1994) Sens Actuators B18–19:704

    Google Scholar 

  48. Walther I, van der Schoot BH, Jeanneret S, Arquint Ph, de Rooij NF, Gass V, Bechler B, Lorenzi G, Cogoli A (1994) J Biotechnol 38:21

    Article  CAS  Google Scholar 

  49. Effenhauser CS, Manz A, Widmer HM (1995) Anal Chem 67:2284

    Article  CAS  Google Scholar 

  50. Jakobson SC, Hergenröder R, Koutny LB, Ramsey JM (1994) Anal Chem 66:1114

    Article  Google Scholar 

  51. Effenhauser CS, Bruin GJM, Paulus A, Ehrat M (1996) Anal Meth Instr Spec Issue µTAS ’96:124

    Google Scholar 

  52. Northrup MA, Beeman B, Hadley D, Landre P, Lehew S (1996) Anal Meth Instr Spec Issue µTAS ’96:153

    Google Scholar 

  53. Woudenberg TM, Winn-Deen ES, Albin M (1996) Anal Meth Instr Spec Issue µTAS ’96:55

    Google Scholar 

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Authors and Affiliations

  1. MESA Research Institute, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands

    Albert van den Berg & T. S. J. Lammerink

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  1. Albert van den Berg
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  2. T. S. J. Lammerink
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Editors and Affiliations

  1. Department of Chemistry Imperial College of Science and Technology, Zeneca/Smithkline Beecham Centre for Analytical Sciences, South Kensington London, SW7 2AY

    Andreas Manz  & Holger Becker  & 

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van den Berg, A., Lammerink, T.S.J. (1998). Micro Total Analysis Systems: Microfluidic Aspects, Integration Concept and Applications. In: Manz, A., Becker, H. (eds) Microsystem Technology in Chemistry and Life Science. Topics in Current Chemistry, vol 194. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-69544-3_2

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  • DOI: https://doi.org/10.1007/3-540-69544-3_2

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  • Online ISBN: 978-3-540-69544-8

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