Chapter

Biocatalysis - From Discovery to Application

Volume 200 of the series Topics in Current Chemistry pp 59-93

Date:

Catalytic Antibodies for Organic Synthesis

  • Jean-Louis ReymondAffiliated withDepartment of Chemistry & Biochemistry, University of Bern

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Abstract

Monoclonal antibodies with strong binding affinities tailored to any molecular target can be produced from immunized mice using hybridoma technology. Due to their directable binding specificities and ease of preparation, monoclonal antibodies are used in the daily practice of biological research as well as in many diagnostic applications. Since 1986 monoclonal antibodies with catalytic properties have been prepared by immunizing mice with stable transition state analogs of chemical reactions, thereby providing a versatile source of novel biocatalysts. This review discusses catalytic antibodies with respect to organic synthetic reactions.

Keywords

Catalytic antibodies Biotransformations Enantioselective reactions Transition state analogs High throughput screening