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Genomic database applications in DISCO

  • Peter Z. Revesz
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 1191)

Abstract

A genome map is an ordering of a set of clones according to their believed position on a DNA string. Simple heuristics for genome map assembly based on single restriction enzyme with complete digestion data can lead to inaccuracies and ambiguities. This paper presents a method that adds additional constraint checking to the assembly process. An automaton is presented that for any genome map produces a refined genome map where both the clones and the restriction fragments in each clone are ordered satisfying natural constraints called step constraints. Any genome map that cannot be refined is highly likely to be inaccurate and can be eliminated as a possibility.

Keywords

Restriction Fragment Atomic Formula Conjunctive Normal Form Deductive Database Constraint Logic Programming 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • Peter Z. Revesz
    • 1
  1. 1.Department of Computer Science and EngineeringUniversity of NebraskaLincolnUSA

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